STRINGSTRING
POLR2G POLR2G HRAS HRAS FNDC3A FNDC3A PTBP2 PTBP2 KLB KLB POLR2C POLR2C PPP2CB PPP2CB FGF2 FGF2 FGF23 FGF23 Rps27a Rps27a FGF18 FGF18 FGFR1 FGFR1 PIK3CA PIK3CA FGF3 FGF3 PIK3R1 PIK3R1 FGF16 FGF16 FGFRL1 FGFRL1 FGF19 FGF19 LOC100734047 LOC100734047 FRS3 FRS3 FGF20 FGF20 NRAS NRAS KRAS KRAS FNDC3B FNDC3B POLR2I POLR2I GAB1 GAB1 UBA52 UBA52 FGF5 FGF5 Polr2j Polr2j POLR2E POLR2E SOS1 SOS1 POLR2D POLR2D FRS2 FRS2 NCBP2 NCBP2 ESRP2 ESRP2 STIL STIL GALNT3 GALNT3 FGF22 FGF22 NCBP1 NCBP1 GTF2F1 GTF2F1 MAPK1 MAPK1 ANOS1 ANOS1 PTPN11 PTPN11 FGF4 FGF4 FGF17 FGF17 POLR2A POLR2A MKNK2 MKNK2 FLRT1 FLRT1 Hnrnpa1 Hnrnpa1 FGF8 FGF8 PLCG1 PLCG1 KL KL H0W160_CAVPO H0W160_CAVPO SHC1 SHC1 FGFBP1 FGFBP1 LOC100732533 LOC100732533 H0WAD6_CAVPO H0WAD6_CAVPO RBFOX2 RBFOX2 H0WDT2_CAVPO H0WDT2_CAVPO PTBP1 PTBP1 FGF10 FGF10 ESRP1 ESRP1 MAPK3 MAPK3 PPP2CA PPP2CA POLR2L POLR2L POLR2B POLR2B FGF1 FGF1 FLRT2 FLRT2 FGFR3 FGFR3 FLRT3 FLRT3 FGF7 FGF7 FGFR2 FGFR2 POLR2H POLR2H FGF6 FGF6 TIA1 TIA1 Mknk1 Mknk1 CBL CBL ENSCPOP00000029646 ENSCPOP00000029646 SPRED2 SPRED2 UBB UBB POLR2F POLR2F PTBP3 PTBP3 GTF2F2 GTF2F2 POLR2K POLR2K Fgf9 Fgf9 SPRY2 SPRY2 ENSCPOP00000031632 ENSCPOP00000031632 GRB2 GRB2 BRAF BRAF FGFR4 FGFR4 ENSCPOP00000031782 ENSCPOP00000031782 HNRNPM HNRNPM CSDE1 CSDE1 Ubc Ubc SPRED1 SPRED1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLR2GRNA polymerase II subunit G. (172 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FNDC3AFibronectin type III domain containing 3A. (1172 aa)
PTBP2Polypyrimidine tract binding protein 2. (531 aa)
KLBKlotho beta. (1024 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (257 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGFRL1Fibroblast growth factor receptor like 1. (488 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
LOC100734047Uncharacterized protein. (567 aa)
FRS3Fibroblast growth factor receptor substrate 3. (485 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FNDC3BFibronectin type III domain containing 3B. (1101 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (269 aa)
Polr2jRNA polymerase II subunit J. (117 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa)
ESRP2Epithelial splicing regulatory protein 2. (719 aa)
STILSTIL centriolar assembly protein. (1049 aa)
GALNT3Polypeptide N-acetylgalactosaminyltransferase. (633 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (160 aa)
NCBP1Nuclear cap binding protein subunit 1. (764 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (522 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
ANOS1Anosmin 1. (649 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (588 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1833 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (674 aa)
Hnrnpa1RRM domain-containing protein. (324 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
KLKlotho. (760 aa)
H0W160_CAVPOUncharacterized protein. (589 aa)
SHC1SHC adaptor protein 1. (583 aa)
FGFBP1Fibroblast growth factor binding protein 1. (242 aa)
LOC100732533Uncharacterized protein. (311 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
RBFOX2RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (396 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
PTBP1Polypyrimidine tract binding protein 1. (557 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ESRP1Epithelial splicing regulatory protein 1. (681 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
FGFR3Fibroblast growth factor receptor. (801 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TIA1TIA1 cytotoxic granule associated RNA binding protein. (398 aa)
Mknk1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (421 aa)
CBLCbl proto-oncogene. (894 aa)
ENSCPOP00000029646RRM domain-containing protein. (236 aa)
SPRED2Sprouty related EVH1 domain containing 2. (413 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
POLR2FRNA polymerase II subunit F. (127 aa)
PTBP3Polypyrimidine tract binding protein 3. (551 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (91 aa)
SPRY2Sprouty RTK signaling antagonist 2. (316 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (738 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
ENSCPOP00000031782Uncharacterized protein. (133 aa)
HNRNPMHeterogeneous nuclear ribonucleoprotein M. (730 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
UbcUncharacterized protein. (159 aa)
SPRED1Sprouty related EVH1 domain containing 1. (438 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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