STRINGSTRING
PLEKHG5 PLEKHG5 UBB UBB ITGB3BP ITGB3BP Ywhae Ywhae PSENEN PSENEN NGEF NGEF ARHGEF10L ARHGEF10L CASP2 CASP2 ABR ABR ARHGEF15 ARHGEF15 FGD3 FGD3 Rtn4 Rtn4 PSEN1 PSEN1 MAPK8 MAPK8 FGD1 FGD1 ARHGEF9 ARHGEF9 VAV2 VAV2 SQSTM1 SQSTM1 ARHGEF2 ARHGEF2 ENSCPOP00000033096 ENSCPOP00000033096 ARHGEF17 ARHGEF17 FGD4 FGD4 BEX3 BEX3 IRAK1 IRAK1 ARHGDIA ARHGDIA Ubc Ubc ENSCPOP00000031692 ENSCPOP00000031692 ENSCPOP00000031632 ENSCPOP00000031632 PLEKHG2 PLEKHG2 OMG OMG UBA52 UBA52 ARHGEF39 ARHGEF39 VAV3 VAV3 ITSN1 ITSN1 ARHGEF3 ARHGEF3 FGD2 FGD2 PSEN2 PSEN2 LINGO1 LINGO1 SOS1 SOS1 ARHGEF37 ARHGEF37 ARHGEF11 ARHGEF11 MCF2 MCF2 ARHGEF4 ARHGEF4 TRAF6 TRAF6 ECT2 ECT2 APH1B APH1B NFKBIA NFKBIA ARHGEF5 ARHGEF5 Bad Bad Rps27a Rps27a AATF AATF RIPK2 RIPK2 APH1A APH1A ECT2L ECT2L ARHGEF26 ARHGEF26 NFKB1 NFKB1 H0VBD1_CAVPO H0VBD1_CAVPO LINGO2 LINGO2 TIAM2 TIAM2 ARHGEF12 ARHGEF12 ARHGEF6 ARHGEF6 IKBKB IKBKB ARHGEF7 ARHGEF7 ADAM17 ADAM17 MAG MAG KALRN KALRN Casp3 Casp3 ARHGEF40 ARHGEF40 GNA13 GNA13 TIAM1 TIAM1 PRDM4 PRDM4 NET1 NET1 NCSTN NCSTN H0VT19_CAVPO H0VT19_CAVPO TGM6 TGM6 Sestd1 Sestd1 H0VYJ9_CAVPO H0VYJ9_CAVPO ARHGEF16 ARHGEF16 MCF2L MCF2L ARHGEF33 ARHGEF33 H0W5H3_CAVPO H0W5H3_CAVPO MYD88 MYD88 RTN4R RTN4R H0WAD6_CAVPO H0WAD6_CAVPO NGF NGF Arhgef25 Arhgef25 ARHGEF10 ARHGEF10 H0WDT2_CAVPO H0WDT2_CAVPO Arhgef19 Arhgef19 Arhgef1 Arhgef1 RHOA RHOA SOS2 SOS2 RAC1 RAC1 TRIO TRIO BCL2L11 BCL2L11 ENSCPOP00000030352 ENSCPOP00000030352 ENSCPOP00000030285 ENSCPOP00000030285
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1051 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
ITGB3BPIntegrin subunit beta 3 binding protein. (198 aa)
Ywhae14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
NGEFNeuronal guanine nucleotide exchange factor. (705 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10 like. (1278 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
ABRABR activator of RhoGEF and GTPase. (859 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15. (838 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (726 aa)
Rtn4Reticulon. (350 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (952 aa)
ARHGEF9Cdc42 guanine nucleotide exchange factor 9. (518 aa)
VAV2Vav guanine nucleotide exchange factor 2. (807 aa)
SQSTM1Sequestosome 1. (415 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (986 aa)
ENSCPOP00000033096DH domain-containing protein. (302 aa)
ARHGEF17Rho guanine nucleotide exchange factor 17. (1815 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (904 aa)
BEX3Brain expressed X-linked 3. (111 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
ARHGDIARho GDP-dissociation inhibitor 1; Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. T [...] (204 aa)
UbcUncharacterized protein. (159 aa)
ENSCPOP00000031692CRAL-TRIO domain-containing protein. (645 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
PLEKHG2Pleckstrin homology and RhoGEF domain containing G2. (1359 aa)
OMGOligodendrocyte myelin glycoprotein. (443 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (331 aa)
VAV3Vav guanine nucleotide exchange factor 3. (779 aa)
ITSN1Intersectin 1. (1657 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (558 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (627 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
ARHGEF37Rho guanine nucleotide exchange factor 37. (671 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1494 aa)
MCF2MCF.2 cell line derived transforming sequence. (1033 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (486 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
ECT2Epithelial cell transforming 2. (913 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1597 aa)
BadUncharacterized protein. (166 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
AATFApoptosis antagonizing transcription factor. (568 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (442 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
ECT2LEpithelial cell transforming 2 like. (948 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (654 aa)
NFKB1Nuclear factor kappa B subunit 1. (967 aa)
H0VBD1_CAVPO14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (105 aa)
LINGO2Leucine rich repeat and Ig domain containing 2. (606 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1697 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1496 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (765 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (753 aa)
ADAM17ADAM metallopeptidase domain 17. (826 aa)
MAGMyelin associated glycoprotein. (592 aa)
KALRNKalirin RhoGEF kinase. (2964 aa)
Casp3CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (165 aa)
ARHGEF40Rho guanine nucleotide exchange factor 40. (1518 aa)
GNA13G protein subunit alpha 13. (377 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1590 aa)
PRDM4RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. (1310 aa)
NET1Neuroepithelial cell transforming 1. (597 aa)
NCSTNNicastrin. (709 aa)
H0VT19_CAVPOTGc domain-containing protein. (700 aa)
TGM6Transglutaminase 6. (706 aa)
Sestd1CRAL-TRIO domain-containing protein. (696 aa)
H0VYJ9_CAVPOUncharacterized protein. (1418 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (699 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (1164 aa)
ARHGEF33Rho guanine nucleotide exchange factor 33. (845 aa)
H0W5H3_CAVPODH domain-containing protein. (206 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (294 aa)
RTN4RReticulon 4 receptor. (434 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. (308 aa)
Arhgef25Uncharacterized protein. (574 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (926 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
Arhgef19Uncharacterized protein. (157 aa)
Arhgef1RGS-like domain-containing protein. (102 aa)
RHOARas homolog family member A. (193 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3062 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
ENSCPOP00000030352Uncharacterized protein. (97 aa)
ENSCPOP00000030285Uncharacterized protein. (1035 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.