STRINGSTRING
PSMC5 PSMC5 AXIN1 AXIN1 PSMD7 PSMD7 PSMD8 PSMD8 PPP2R5D PPP2R5D TLE4 TLE4 CTNNB1 CTNNB1 PSMD11 PSMD11 PSMC6 PSMC6 LOC100734047 LOC100734047 ZRANB1 ZRANB1 PSMB7 PSMB7 AMER1 AMER1 PSMD6 PSMD6 Rps27a Rps27a BTRC BTRC PPP2CB PPP2CB SKP1 SKP1 PSMC4 PSMC4 PSMD13 PSMD13 PSMB9 PSMB9 APC APC PSMB6 PSMB6 PSMB1 PSMB1 PSMB8 PSMB8 UBA52 UBA52 CTBP1 CTBP1 PPP2R5C PPP2R5C H0W160_CAVPO H0W160_CAVPO CUL1 CUL1 PPP2R5B PPP2R5B H0VWS1_CAVPO H0VWS1_CAVPO PSMC2 PSMC2 H0VV76_CAVPO H0VV76_CAVPO PSMA1 PSMA1 PSMB4 PSMB4 PSMD3 PSMD3 Psmd10 Psmd10 PSME3 PSME3 CTBP2 CTBP2 Psma2 Psma2 Ubc Ubc PSME2 PSME2 ENSCPOP00000031632 ENSCPOP00000031632 PSMC1 PSMC1 TLE2 TLE2 UBB UBB PSMA6 PSMA6 PSMB2 PSMB2 ENSCPOP00000029251 ENSCPOP00000029251 PSMD12 PSMD12 TCF7L1 TCF7L1 GSK3B GSK3B PSMA7 PSMA7 PSMB5 PSMB5 PSMF1 PSMF1 PSMA5 PSMA5 PSMA8 PSMA8 PSME4 PSME4 PSMD4 PSMD4 PSMD14 PSMD14 TLE5 TLE5 TLE1 TLE1 RBX1 RBX1 PPP2R5E PPP2R5E PSMD2 PSMD2 PPP2R1B PPP2R1B PSMC3 PSMC3 PPP2CA PPP2CA LEF1 LEF1 PPP2R5A PPP2R5A PSME1 PSME1 ENSCPOP00000023065 ENSCPOP00000023065 PSMA3 PSMA3 TCF7L2 TCF7L2 CSNK1A1 CSNK1A1 PSMD1 PSMD1 H0WDT2_CAVPO H0WDT2_CAVPO TCF7 TCF7 PSMB10 PSMB10 FRAT2 FRAT2 H0WAD6_CAVPO H0WAD6_CAVPO PSMD5 PSMD5 APC2 APC2 PSMB11 PSMB11 PSMB3 PSMB3 TLE3 TLE3 PSMA4 PSMA4 Psmd9 Psmd9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
AXIN1Axin 1. (863 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (594 aa)
TLE4TLE family member 4, transcriptional corepressor. (758 aa)
CTNNB1Catenin beta 1. (781 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
LOC100734047Uncharacterized protein. (567 aa)
ZRANB1Zinc finger RANBP2-type containing 1. (708 aa)
PSMB7Proteasome subunit beta. (277 aa)
AMER1APC membrane recruitment protein 1. (1127 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (582 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (162 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (315 aa)
PSMB9Proteasome subunit beta. (219 aa)
APCAPC regulator of WNT signaling pathway. (2842 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB8Proteasome subunit beta. (273 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (346 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (589 aa)
H0W160_CAVPOUncharacterized protein. (589 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
H0VWS1_CAVPOANK_REP_REGION domain-containing protein. (213 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
H0VV76_CAVPOProtein kinase domain-containing protein. (196 aa)
PSMA1Proteasome subunit alpha type. (270 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
Psmd10ANK_REP_REGION domain-containing protein. (232 aa)
PSME3Proteasome activator subunit 3. (254 aa)
CTBP2C-terminal binding protein 2. (978 aa)
Psma2Proteasome subunit alpha type. (234 aa)
UbcUncharacterized protein. (159 aa)
PSME2Proteasome activator subunit 2. (239 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
TLE2TLE family member 2, transcriptional corepressor. (663 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMB2Proteasome subunit beta. (201 aa)
ENSCPOP00000029251Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
PSME4Proteasome activator subunit 4. (1827 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
TLE5TLE family member 5, transcriptional modulator. (189 aa)
TLE1TLE family member 1, transcriptional corepressor. (798 aa)
RBX1Ring-box 1. (108 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (696 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
LEF1Lymphoid enhancer binding factor 1. (396 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
PSME1Proteasome activator subunit 1. (249 aa)
ENSCPOP00000023065ANK_REP_REGION domain-containing protein. (179 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
TCF7L2Transcription factor 7 like 2. (350 aa)
CSNK1A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
TCF7Transcription factor 7. (262 aa)
PSMB10Proteasome subunit beta. (273 aa)
FRAT2FRAT regulator of WNT signaling pathway 2. (188 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
APC2APC regulator of WNT signaling pathway 2. (2086 aa)
PSMB11Proteasome subunit beta. (297 aa)
PSMB3Proteasome subunit beta. (207 aa)
TLE3TLE family member 3, transcriptional corepressor. (769 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
Psmd9PDZ domain-containing protein. (223 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.