STRINGSTRING
TRAF6 TRAF6 ARHGEF4 ARHGEF4 MCF2 MCF2 ARHGEF11 ARHGEF11 ARHGEF37 ARHGEF37 SOS1 SOS1 PSEN2 PSEN2 FGD2 FGD2 ARHGEF3 ARHGEF3 ITSN1 ITSN1 VAV3 VAV3 ARHGEF39 ARHGEF39 UBA52 UBA52 ENSCPOP00000030352 ENSCPOP00000030352 BCL2L11 BCL2L11 MAPK8 MAPK8 FGD1 FGD1 ARHGEF9 ARHGEF9 VAV2 VAV2 SQSTM1 SQSTM1 ARHGEF2 ARHGEF2 TRIO TRIO RAC1 RAC1 SOS2 SOS2 Arhgef19 Arhgef19 H0WDT2_CAVPO H0WDT2_CAVPO ARHGEF10 ARHGEF10 Arhgef25 Arhgef25 NGF NGF H0WAD6_CAVPO H0WAD6_CAVPO H0W5H3_CAVPO H0W5H3_CAVPO ARHGEF33 ARHGEF33 MCF2L MCF2L ARHGEF16 ARHGEF16 H0VYJ9_CAVPO H0VYJ9_CAVPO Sestd1 Sestd1 TGM6 TGM6 H0VT19_CAVPO H0VT19_CAVPO NCSTN NCSTN NET1 NET1 TIAM1 TIAM1 GNA13 GNA13 PSEN1 PSEN1 ARHGEF40 ARHGEF40 Casp3 Casp3 KALRN KALRN ARHGEF7 ARHGEF7 ARHGEF6 ARHGEF6 FGD3 FGD3 ARHGEF15 ARHGEF15 ABR ABR Arhgef1 Arhgef1 PLEKHG2 PLEKHG2 ENSCPOP00000031632 ENSCPOP00000031632 ENSCPOP00000031692 ENSCPOP00000031692 Ubc Ubc BEX3 BEX3 FGD4 FGD4 ARHGEF17 ARHGEF17 ENSCPOP00000033096 ENSCPOP00000033096 CASP2 CASP2 ARHGEF10L ARHGEF10L NGEF NGEF PSENEN PSENEN Ywhae Ywhae ITGB3BP ITGB3BP UBB UBB PLEKHG5 PLEKHG5 ENSCPOP00000030285 ENSCPOP00000030285 ARHGEF12 ARHGEF12 TIAM2 TIAM2 H0VBD1_CAVPO H0VBD1_CAVPO ARHGEF26 ARHGEF26 ECT2L ECT2L APH1A APH1A AATF AATF Rps27a Rps27a Bad Bad ARHGEF5 ARHGEF5 APH1B APH1B ECT2 ECT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (486 aa)
MCF2MCF.2 cell line derived transforming sequence. (1033 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1494 aa)
ARHGEF37Rho guanine nucleotide exchange factor 37. (671 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (627 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (558 aa)
ITSN1Intersectin 1. (1657 aa)
VAV3Vav guanine nucleotide exchange factor 3. (779 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (331 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ENSCPOP00000030352Uncharacterized protein. (97 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (952 aa)
ARHGEF9Cdc42 guanine nucleotide exchange factor 9. (518 aa)
VAV2Vav guanine nucleotide exchange factor 2. (807 aa)
SQSTM1Sequestosome 1. (415 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (986 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3062 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
Arhgef19Uncharacterized protein. (157 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (926 aa)
Arhgef25Uncharacterized protein. (574 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. (308 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
H0W5H3_CAVPODH domain-containing protein. (206 aa)
ARHGEF33Rho guanine nucleotide exchange factor 33. (845 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (1164 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (699 aa)
H0VYJ9_CAVPOUncharacterized protein. (1418 aa)
Sestd1CRAL-TRIO domain-containing protein. (696 aa)
TGM6Transglutaminase 6. (706 aa)
H0VT19_CAVPOTGc domain-containing protein. (700 aa)
NCSTNNicastrin. (709 aa)
NET1Neuroepithelial cell transforming 1. (597 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1590 aa)
GNA13G protein subunit alpha 13. (377 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ARHGEF40Rho guanine nucleotide exchange factor 40. (1518 aa)
Casp3CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (165 aa)
KALRNKalirin RhoGEF kinase. (2964 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (753 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (765 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (726 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15. (838 aa)
ABRABR activator of RhoGEF and GTPase. (859 aa)
Arhgef1RGS-like domain-containing protein. (102 aa)
PLEKHG2Pleckstrin homology and RhoGEF domain containing G2. (1359 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
ENSCPOP00000031692CRAL-TRIO domain-containing protein. (645 aa)
UbcUncharacterized protein. (159 aa)
BEX3Brain expressed X-linked 3. (111 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (904 aa)
ARHGEF17Rho guanine nucleotide exchange factor 17. (1815 aa)
ENSCPOP00000033096DH domain-containing protein. (302 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10 like. (1278 aa)
NGEFNeuronal guanine nucleotide exchange factor. (705 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
Ywhae14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
ITGB3BPIntegrin subunit beta 3 binding protein. (198 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1051 aa)
ENSCPOP00000030285Uncharacterized protein. (1035 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1496 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1697 aa)
H0VBD1_CAVPO14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (105 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (654 aa)
ECT2LEpithelial cell transforming 2 like. (948 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
AATFApoptosis antagonizing transcription factor. (568 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
BadUncharacterized protein. (166 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1597 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
ECT2Epithelial cell transforming 2. (913 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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