STRINGSTRING
H0W987_CAVPO H0W987_CAVPO AOC1 AOC1 LOC100719102 LOC100719102 FADS6 FADS6 POMC POMC CBFA2T3 CBFA2T3 LOC100734566 LOC100734566 H0WCC9_CAVPO H0WCC9_CAVPO CYP2B6 CYP2B6 LOC100734845 LOC100734845 LOC100719511 LOC100719511 LOC100714126 LOC100714126 FAM78A FAM78A NCOA2 NCOA2 EPHX1 EPHX1 LOC100724941 LOC100724941 LOC100717473 LOC100717473 RUNX1T1 RUNX1T1 CYP4F22 CYP4F22 CBFA2T2 CBFA2T2 NCOA1 NCOA1 LOC100719230 LOC100719230 CYP2E1 CYP2E1 NQO2 NQO2 FMO4 FMO4 ENSCPOP00000024925 ENSCPOP00000024925 CYP7B1 CYP7B1 CMBL CMBL BPHL BPHL LOC100716545 LOC100716545 LOC100723931 LOC100723931 CYP2F1 CYP2F1 CBR3 CBR3 AIPL1 AIPL1 LOC100717002 LOC100717002 LOC100722818 LOC100722818 Aldh2 Aldh2 Mtarc1 Mtarc1 LOC100727028 LOC100727028 CYP4V2 CYP4V2 CYP1B1 CYP1B1 PTGIS PTGIS ENSCPOP00000028465 ENSCPOP00000028465 ADH5 ADH5 ENSCPOP00000028982 ENSCPOP00000028982 FMO3 FMO3 PTGES3 PTGES3 LOC100715321 LOC100715321 FOXRED2 FOXRED2 ENSCPOP00000029971 ENSCPOP00000029971 CYB5B CYB5B CES3 CES3 LOC100732581 LOC100732581 LOC100721835 LOC100721835 LOC100734360 LOC100734360 LOC100715799 LOC100715799 FDX1 FDX1 LOC100732853 LOC100732853 LOC100730472 LOC100730472 CYP2R1 CYP2R1 TBXAS1 TBXAS1 RXRA RXRA H0UTG5_CAVPO H0UTG5_CAVPO AADACL3 AADACL3 LOC100716515 LOC100716515 MAOB MAOB Fdx2 Fdx2 MAOA MAOA CYP27A1 CYP27A1 Cyp3a14 Cyp3a14 LOC100734717 LOC100734717 LOC100718401 LOC100718401 NR1H4 NR1H4 LOC100719371 LOC100719371 LOC100727788 LOC100727788 LOC100717930 LOC100717930 ALDH16A1 ALDH16A1 CYP4X1 CYP4X1 CCNDBP1 CCNDBP1 CYP7A1 CYP7A1 CYP26C1 CYP26C1 AADAC AADAC ACSS2 ACSS2 H0V479_CAVPO H0V479_CAVPO LOC100733122 LOC100733122 Ahr Ahr POR POR CYP2W1 CYP2W1 H0V5V1_CAVPO H0V5V1_CAVPO LOC100723652 LOC100723652 Ahrr Ahrr CYP26B1 CYP26B1 LOC100733616 LOC100733616 PTGES3L PTGES3L LOC100732008 LOC100732008 PTGS1 PTGS1 CYP2S1 CYP2S1 FAM78B FAM78B LOC100716044 LOC100716044 CYP20A1 CYP20A1 CYP24A1 CYP24A1 Aadacl4 Aadacl4 LOC100719356 LOC100719356 CYP4F8 CYP4F8 Ces1d Ces1d H0VIC7_CAVPO H0VIC7_CAVPO LOC100723678 LOC100723678 LOC100720199 LOC100720199 LOC100735467 LOC100735467 CYP2U1 CYP2U1 Paox Paox AOC3 AOC3 Cyp3a15 Cyp3a15 Cyp3a17 Cyp3a17 ARNT2 ARNT2 LOC100728571 LOC100728571 CYP11B1 CYP11B1 CYP19A1 CYP19A1 Fmo5 Fmo5 FMO2 FMO2 FMO1 FMO1 Arnt Arnt CYP51A1 CYP51A1 LOC100735934 LOC100735934 CYP1A1 CYP1A1 ALDH3A1 ALDH3A1 TTI2 TTI2 LOC100733965 LOC100733965 H0VU94_CAVPO H0VU94_CAVPO CYP26A1 CYP26A1 LOC100718540 LOC100718540 SMOX SMOX MARC2 MARC2 AIP AIP CYB5R3 CYB5R3 H0W0J6_CAVPO H0W0J6_CAVPO CYP46A1 CYP46A1 FDXR FDXR CYP2D16 CYP2D16 CYP27B1 CYP27B1 CYP1A2 CYP1A2 LOC100734190 LOC100734190 ACSS1 ACSS1 H0W5X3_CAVPO H0W5X3_CAVPO H0W627_CAVPO H0W627_CAVPO LOC100729591 LOC100729591 Cyp11b2 Cyp11b2 LOC100733688 LOC100733688 LOC100733735 LOC100733735 LOC100716263 LOC100716263 LOC100713503 LOC100713503
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H0W987_CAVPOUncharacterized protein; Belongs to the cytochrome P450 family. (386 aa)
AOC1Amine oxidase. (753 aa)
LOC100719102Uncharacterized protein. (449 aa)
FADS6Fatty acid desaturase 6. (341 aa)
POMCCorticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. (342 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (614 aa)
LOC100734566Uncharacterized protein. (558 aa)
H0WCC9_CAVPOUncharacterized protein. (384 aa)
CYP2B6Cytochrome P450 family 2 subfamily B member 6. (431 aa)
LOC100734845Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa)
LOC100719511Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
LOC100714126Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (558 aa)
FAM78AFamily with sequence similarity 78 member A. (283 aa)
NCOA2Nuclear receptor coactivator. (1462 aa)
EPHX1Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (455 aa)
LOC100724941COesterase domain-containing protein; Belongs to the type-B carboxylesterase/lipase family. (792 aa)
LOC100717473Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (602 aa)
CYP4F22Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (547 aa)
CBFA2T2CBFA2/RUNX1 partner transcriptional co-repressor 2. (595 aa)
NCOA1Nuclear receptor coactivator. (1442 aa)
LOC100719230Uncharacterized protein; Belongs to the cytochrome P450 family. (338 aa)
CYP2E1Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (496 aa)
NQO2N-ribosyldihydronicotinamide:quinone reductase 2. (231 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (538 aa)
ENSCPOP00000024925COesterase domain-containing protein. (295 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (493 aa)
CMBLCarboxymethylenebutenolidase homolog. (245 aa)
BPHLBiphenyl hydrolase like. (291 aa)
LOC100716545Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
LOC100723931Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (462 aa)
CYP2F1Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (414 aa)
CBR3Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (273 aa)
AIPL1Aryl hydrocarbon receptor interacting protein like 1. (328 aa)
LOC100717002Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
LOC100722818Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
Aldh2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (521 aa)
Mtarc1MOSC domain-containing protein. (334 aa)
LOC100727028PKS_ER domain-containing protein. (382 aa)
CYP4V2Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (524 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (540 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (475 aa)
ENSCPOP00000028465Uncharacterized protein; Belongs to the cytochrome P450 family. (207 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (367 aa)
ENSCPOP00000028982Uncharacterized protein; Belongs to the cytochrome P450 family. (435 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
PTGES3Prostaglandin E synthase 3. (160 aa)
LOC100715321Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
FOXRED2FAD dependent oxidoreductase domain containing 2. (682 aa)
ENSCPOP00000029971Aldedh domain-containing protein. (216 aa)
CYB5BCytochrome b5 type B; Belongs to the cytochrome b5 family. (146 aa)
CES3Carboxylesterase 3. (460 aa)
LOC100732581Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (501 aa)
LOC100721835Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
LOC100734360Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (559 aa)
LOC100715799Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
FDX1Ferredoxin 1. (124 aa)
LOC100732853Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (500 aa)
LOC100730472Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (559 aa)
CYP2R1Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (501 aa)
TBXAS1Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (533 aa)
RXRARetinoid X receptor alpha. (459 aa)
H0UTG5_CAVPOUncharacterized protein; Belongs to the cytochrome P450 family. (509 aa)
AADACL3Arylacetamide deacetylase like 3. (385 aa)
LOC100716515Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (522 aa)
MAOBAmine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). (520 aa)
Fdx22Fe-2S ferredoxin-type domain-containing protein. (174 aa)
MAOAAmine oxidase. (461 aa)
CYP27A1Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (566 aa)
Cyp3a14Cytochrome P450 3A14; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (503 aa)
LOC100734717Uncharacterized protein. (501 aa)
LOC100718401Uncharacterized protein; Belongs to the cytochrome P450 family. (504 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (484 aa)
LOC100719371Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
LOC100727788Uncharacterized protein; Belongs to the cytochrome P450 family. (212 aa)
LOC100717930Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa)
ALDH16A1Aldehyde dehydrogenase family 16 member A1. (804 aa)
CYP4X1Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (493 aa)
CCNDBP1Cyclin D1 binding protein 1. (355 aa)
CYP7A1Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family. (496 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (517 aa)
AADACArylacetamide deacetylase. (353 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (713 aa)
H0V479_CAVPOCOesterase domain-containing protein. (84 aa)
LOC100733122Dimethylaniline monooxygenase [N-oxide-forming]. (539 aa)
AhrUncharacterized protein. (832 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. (677 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (496 aa)
H0V5V1_CAVPOCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (441 aa)
LOC100723652Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (507 aa)
AhrrUncharacterized protein. (654 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
LOC100733616Uncharacterized protein; Belongs to the cytochrome P450 family. (319 aa)
PTGES3LProstaglandin E synthase 3 like. (149 aa)
LOC100732008PKS_ER domain-containing protein. (375 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (553 aa)
CYP2S1Cytochrome P450 family 2 subfamily S member 1. (503 aa)
FAM78BFamily with sequence similarity 78 member B. (261 aa)
LOC100716044Cytochrome P450 2C-like protein; Belongs to the cytochrome P450 family. (490 aa)
CYP20A1Cytochrome P450 family 20 subfamily A member 1. (462 aa)
CYP24A1Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (501 aa)
Aadacl4Uncharacterized protein. (390 aa)
LOC100719356Uncharacterized protein; Belongs to the cytochrome P450 family. (511 aa)
CYP4F8Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family. (516 aa)
Ces1dCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
H0VIC7_CAVPOUncharacterized protein; Belongs to the cytochrome P450 family. (460 aa)
LOC100723678Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa)
LOC100720199Uncharacterized protein; Belongs to the cytochrome P450 family. (498 aa)
LOC100735467Uncharacterized protein. (408 aa)
CYP2U1Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (529 aa)
PaoxAmino_oxidase domain-containing protein. (513 aa)
AOC3Amine oxidase. (787 aa)
Cyp3a15Uncharacterized protein; Belongs to the cytochrome P450 family. (455 aa)
Cyp3a17Uncharacterized protein; Belongs to the cytochrome P450 family. (488 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (715 aa)
LOC100728571Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
CYP11B1Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] (409 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
Fmo5Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. (533 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming] 2; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. (539 aa)
FMO1Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
ArntUncharacterized protein. (775 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
LOC100735934Uncharacterized protein. (408 aa)
CYP1A1Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (516 aa)
ALDH3A1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (453 aa)
TTI2TELO2 interacting protein 2. (502 aa)
LOC100733965Dimethylaniline monooxygenase [N-oxide-forming]. (539 aa)
H0VU94_CAVPOCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (520 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
LOC100718540Uncharacterized protein. (447 aa)
SMOXSpermine oxidase. (585 aa)
MARC2Mitochondrial amidoxime reducing component 2. (336 aa)
AIPAryl hydrocarbon receptor interacting protein. (330 aa)
CYB5R3NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (301 aa)
H0W0J6_CAVPOUncharacterized protein. (384 aa)
CYP46A1Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (486 aa)
FDXRNADPH:adrenodoxin oxidoreductase, mitochondrial. (493 aa)
CYP2D16Cytochrome P450 2D16; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (500 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (509 aa)
CYP1A2Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (515 aa)
LOC100734190Uncharacterized protein. (369 aa)
ACSS1Acetyl-coenzyme A synthetase. (647 aa)
H0W5X3_CAVPOUncharacterized protein; Belongs to the cytochrome P450 family. (284 aa)
H0W627_CAVPOUncharacterized protein. (270 aa)
LOC100729591Uncharacterized protein; Belongs to the cytochrome P450 family. (505 aa)
Cyp11b2Uncharacterized protein; Belongs to the cytochrome P450 family. (479 aa)
LOC100733688Dimethylaniline monooxygenase [N-oxide-forming]. (538 aa)
LOC100733735Uncharacterized protein; Belongs to the cytochrome P450 family. (524 aa)
LOC100716263Uncharacterized protein; Belongs to the cytochrome P450 family. (488 aa)
LOC100713503Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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