STRINGSTRING
SMAD4 SMAD4 UBA52 UBA52 LTBP2 LTBP2 STRAP STRAP TGFB1 TGFB1 MTMR4 MTMR4 Rps27a Rps27a LTBP1 LTBP1 TGFB2 TGFB2 PCSK4 PCSK4 ITGB8 ITGB8 ITGB5 ITGB5 ITGA8 ITGA8 NEDD8 NEDD8 Itgb3 Itgb3 SMAD2 SMAD2 TGFBR1 TGFBR1 ITGAV ITGAV STUB1 STUB1 ITGB6 ITGB6 H0WAD6_CAVPO H0WAD6_CAVPO H0WDT2_CAVPO H0WDT2_CAVPO SMURF2 SMURF2 SMAD7 SMAD7 PMEPA1 PMEPA1 Fkbp1a Fkbp1a LTBP4 LTBP4 FURIN FURIN TGFBR2 TGFBR2 TGFB3 TGFB3 CBL CBL UBE2M UBE2M UBB UBB FBN1 FBN1 SMAD3 SMAD3 ZFYVE9 ZFYVE9 LTBP3 LTBP3 ENSCPOP00000031632 ENSCPOP00000031632 ITGB1 ITGB1 Ubc Ubc BAMBI BAMBI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD4Mothers against decapentaplegic homolog. (552 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1773 aa)
STRAPSerine/threonine kinase receptor associated protein. (350 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
MTMR4Myotubularin related protein 4. (1189 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1577 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (639 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
NEDD8NEDD8 ubiquitin like modifier. (83 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (735 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (963 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (788 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
SMURF2E3 ubiquitin-protein ligase. (782 aa)
SMAD7SMAD family member 7. (221 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (245 aa)
Fkbp1aPeptidylprolyl isomerase. (108 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1585 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (796 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CBLCbl proto-oncogene. (894 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
FBN1Fibrillin 1. (2872 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1322 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1017 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
UbcUncharacterized protein. (159 aa)
BAMBIBMP and activin membrane bound inhibitor. (234 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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