STRINGSTRING
SNW1 SNW1 Cdk9 Cdk9 TRIM33 TRIM33 CCNQ CCNQ H0VDT0_CAVPO H0VDT0_CAVPO PCSK4 PCSK4 HDAC1 HDAC1 SKIL SKIL SMAD4 SMAD4 SKI SKI Rps27a Rps27a PPM1A PPM1A MEN1 MEN1 RBL1 RBL1 NCOR1 NCOR1 UBA52 UBA52 TGIF2 TGIF2 CCNT1 CCNT1 RNF111 RNF111 Tgif1 Tgif1 FURIN FURIN ATP1B4 ATP1B4 Ubc Ubc Irx2 Irx2 UBB UBB CCNT2 CCNT2 IRX3 IRX3 CDK8 CDK8 USP9X USP9X MAPK3 MAPK3 CCNK CCNK TFDP2 TFDP2 UBE2D1 UBE2D1 H0WDT2_CAVPO H0WDT2_CAVPO MEIS3 MEIS3 H0WAD6_CAVPO H0WAD6_CAVPO ENSCPOP00000031632 ENSCPOP00000031632 SMAD3 SMAD3 MKX MKX NEDD4L NEDD4L SMURF2 SMURF2 SMAD7 SMAD7 H0W9U2_CAVPO H0W9U2_CAVPO SP1 SP1 NCOR2 NCOR2 IRX4 IRX4 IRX1 IRX1 JUNB JUNB Parp1 Parp1 IRX6 IRX6 TFDP1 TFDP1 SMAD2 SMAD2 MAPK1 MAPK1 IRX5 IRX5 CCNC CCNC ENSCPOP00000024428 ENSCPOP00000024428 E2F4 E2F4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNW1SNW domain containing 1. (535 aa)
Cdk9Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa)
TRIM33Tripartite motif containing 33. (1128 aa)
CCNQCyclin Q; Belongs to the cyclin family. (249 aa)
H0VDT0_CAVPOProtein kinase domain-containing protein. (337 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (639 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
SKILSKI like proto-oncogene. (679 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SKISKI proto-oncogene. (586 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
MEN1Menin 1. (615 aa)
RBL1RB transcriptional corepressor like 1. (1051 aa)
NCOR1Nuclear receptor corepressor 1. (2389 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (727 aa)
RNF111Ring finger protein 111. (994 aa)
Tgif1Homeobox domain-containing protein. (99 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (796 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
UbcUncharacterized protein. (159 aa)
Irx2Iroquois homeobox 2. (471 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (734 aa)
IRX3Iroquois homeobox 3. (484 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (449 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2558 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
CCNKCyclin K; Belongs to the cyclin family. (582 aa)
TFDP2Transcription factor. (446 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (139 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
MEIS3Meis homeobox 3. (375 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MKXMohawk homeobox. (352 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (992 aa)
SMURF2E3 ubiquitin-protein ligase. (782 aa)
SMAD7SMAD family member 7. (221 aa)
H0W9U2_CAVPOUncharacterized protein. (143 aa)
SP1Sp1 transcription factor. (786 aa)
NCOR2Nuclear receptor corepressor 2. (2467 aa)
IRX4Iroquois homeobox 4. (425 aa)
IRX1Iroquois homeobox 1. (390 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
IRX6Iroquois homeobox 6. (445 aa)
TFDP1Transcription factor. (411 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
IRX5Iroquois homeobox 5. (477 aa)
CCNCCyclin C; Belongs to the cyclin family. (283 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
E2F4E2F transcription factor 4. (411 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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