STRINGSTRING
MAP4K4 MAP4K4 MAP2K3 MAP2K3 UBA52 UBA52 CDKN2B CDKN2B H0UX36_CAVPO H0UX36_CAVPO EED EED Rad50 Rad50 UBE2E1 UBE2E1 HIRA HIRA PHC2 PHC2 TLX1 TLX1 EZH2 EZH2 KDM6B KDM6B CCNE1 CCNE1 CDC16 CDC16 Rps27a Rps27a Ehmt1 Ehmt1 NME9 NME9 MDM4 MDM4 RB1 RB1 MAPKAPK5 MAPKAPK5 ANAPC2 ANAPC2 CDK2 CDK2 CCNA2 CCNA2 NME8 NME8 Srcap Srcap CDC23 CDC23 CABIN1 CABIN1 ATM ATM DBX2 DBX2 MAP3K15 MAP3K15 H1-0 H1-0 BARX2 BARX2 ANAPC5 ANAPC5 UBN1 UBN1 H0VJY6_CAVPO H0VJY6_CAVPO TNIK TNIK MAP3K6 MAP3K6 EZH1 EZH1 UBE2S UBE2S MAPK1 MAPK1 ANAPC4 ANAPC4 H0VN16_CAVPO H0VN16_CAVPO Ccne2 Ccne2 NBN NBN Anapc11 Anapc11 MAP2K4 MAP2K4 MOV10 MOV10 MRE11 MRE11 EHMT2 EHMT2 TM7SF3 TM7SF3 ETS2 ETS2 Txn Txn Rbbp4 Rbbp4 ANAPC7 ANAPC7 H0VYP1_CAVPO H0VYP1_CAVPO SUZ12 SUZ12 MAPKAPK2 MAPKAPK2 H0VZC1_CAVPO H0VZC1_CAVPO DBX1 DBX1 MAP2K7 MAP2K7 CDKN2A CDKN2A LOC106027455 LOC106027455 H0W1R6_CAVPO H0W1R6_CAVPO CEBPB CEBPB BARHL2 BARHL2 TLX2 TLX2 ASF1B ASF1B H1-1 H1-1 H0W6R4_CAVPO H0W6R4_CAVPO BARX1 BARX1 BARHL1 BARHL1 MAPK7 MAPK7 H0WAD6_CAVPO H0WAD6_CAVPO H1-2 H1-2 NPTXR NPTXR HLX HLX JUN JUN H0WDT2_CAVPO H0WDT2_CAVPO UBE2D1 UBE2D1 CCNA1 CCNA1 MAPKAPK3 MAPKAPK3 MDM2 MDM2 CDK4 CDK4 UBE2C UBE2C FOS FOS NKX1-1 NKX1-1 FAM89A FAM89A MAP2K6 MAP2K6 KAT5 KAT5 MAPK14 MAPK14 RPS6KA2 RPS6KA2 RPS6KA3 RPS6KA3 ANAPC10 ANAPC10 RPS6KA1 RPS6KA1 ETV3 ETV3 FZR1 FZR1 MAPK11 MAPK11 MAPK3 MAPK3 MAPK8 MAPK8 FOSL2 FOSL2 ENSCPOP00000025037 ENSCPOP00000025037 MAPK9 MAPK9 LOC100713990 LOC100713990 CDKN1A CDKN1A RBBP7 RBBP7 TLX3 TLX3 ENSCPOP00000026334 ENSCPOP00000026334 ASF1A ASF1A ENSCPOP00000026647 ENSCPOP00000026647 PHC1 PHC1 CDKN2C CDKN2C ID1 ID1 NPTX1 NPTX1 CDC26 CDC26 ANAPC16 ANAPC16 MAP3K5 MAP3K5 CDKN2D CDKN2D Lmnb2 Lmnb2 CBX2 CBX2 EP400 EP400 ETS1 ETS1 ANAPC1 ANAPC1 PWWP2A PWWP2A TP53 TP53 FAM89B FAM89B UBB UBB MINK1 MINK1 ENSCPOP00000030705 ENSCPOP00000030705 ENSCPOP00000030815 ENSCPOP00000030815 CDK6 CDK6 CDC27 CDC27 ANAPC15 ANAPC15 HMGA1 HMGA1 ENSCPOP00000031632 ENSCPOP00000031632 Scml1 Scml1 CBX7 CBX7 Ubc Ubc LMNB1 LMNB1 CDKN1B CDKN1B MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1198 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
H0UX36_CAVPOETS domain-containing protein. (131 aa)
EEDEmbryonic ectoderm development. (417 aa)
Rad50Zinc-hook domain-containing protein. (1275 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
HIRAProtein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1017 aa)
PHC2Polyhomeotic homolog 2. (846 aa)
TLX1T cell leukemia homeobox 1. (332 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (747 aa)
KDM6BLysine demethylase 6B. (1467 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
CDC16Cell division cycle 16. (620 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
Ehmt1Uncharacterized protein. (1249 aa)
NME9NME/NM23 family member 9; Belongs to the NDK family. (327 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (485 aa)
RB1RB transcriptional corepressor 1. (840 aa)
MAPKAPK5MAPK activated protein kinase 5. (474 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (827 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (429 aa)
NME8NME/NM23 family member 8. (553 aa)
SrcapUncharacterized protein. (3171 aa)
CDC23Cell division cycle 23. (597 aa)
CABIN1Calcineurin binding protein 1. (2139 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa)
DBX2Developing brain homeobox 2. (208 aa)
MAP3K15Mitogen-activated protein kinase kinase kinase 15. (1148 aa)
H1-0H1 histone family member 0. (194 aa)
BARX2BARX homeobox 2. (242 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
UBN1Ubinuclein 1. (1136 aa)
H0VJY6_CAVPOThioredoxin domain-containing protein. (135 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1247 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (747 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (214 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
H0VN16_CAVPOUncharacterized protein. (71 aa)
Ccne2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa)
Anapc11RING-type domain-containing protein. (84 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (386 aa)
MOV10Mov10 RISC complex RNA helicase. (1063 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1188 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
ETS2ETS proto-oncogene 2, transcription factor. (447 aa)
TxnThioredoxin; Belongs to the thioredoxin family. (105 aa)
Rbbp4WD_REPEATS_REGION domain-containing protein. (425 aa)
ANAPC7Anaphase promoting complex subunit 7. (555 aa)
H0VYP1_CAVPOUncharacterized protein. (1054 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (737 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
H0VZC1_CAVPOUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa)
DBX1Developing brain homeobox 1. (336 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (459 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (134 aa)
LOC106027455H15 domain-containing protein. (211 aa)
H0W1R6_CAVPOThioredoxin; Belongs to the thioredoxin family. (106 aa)
CEBPBCCAAT enhancer binding protein beta. (216 aa)
BARHL2BarH like homeobox 2. (383 aa)
TLX2T cell leukemia homeobox 2. (284 aa)
ASF1BAnti-silencing function 1B histone chaperone. (202 aa)
H1-1Histone cluster 1 H1 family member a. (215 aa)
H0W6R4_CAVPOWD_REPEATS_REGION domain-containing protein. (418 aa)
BARX1BARX homeobox 1. (223 aa)
BARHL1BarH like homeobox 1. (327 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (797 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
H1-2Histone cluster 1 H1 family member c. (213 aa)
NPTXRNeuronal pentraxin receptor. (323 aa)
HLXH2.0 like homeobox. (442 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (139 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (420 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (380 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
NKX1-1NK1 homeobox 1. (378 aa)
FAM89AFamily with sequence similarity 89 member A. (174 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
ETV3ETS variant 3. (515 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
MAPK11Mitogen-activated protein kinase. (385 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (325 aa)
ENSCPOP00000025037ETS domain-containing protein. (144 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LOC100713990Histone H2B; Belongs to the histone H2B family. (126 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (169 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (469 aa)
TLX3T cell leukemia homeobox 3. (300 aa)
ENSCPOP00000026334WD_REPEATS_REGION domain-containing protein. (385 aa)
ASF1AAnti-silencing function 1A histone chaperone. (178 aa)
ENSCPOP00000026647Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (343 aa)
PHC1Polyhomeotic homolog 1. (1010 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (151 aa)
NPTX1Neuronal pentraxin 1. (432 aa)
CDC26Cell division cycle 26. (85 aa)
ANAPC16Anaphase promoting complex subunit 16. (118 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1344 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
Lmnb2Uncharacterized protein; Belongs to the intermediate filament family. (617 aa)
CBX2Chromobox 2. (532 aa)
EP400E1A binding protein p400. (3128 aa)
ETS1ETS proto-oncogene 1, transcription factor. (441 aa)
ANAPC1Anaphase promoting complex subunit 1. (1941 aa)
PWWP2APWWP domain containing 2A. (722 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
FAM89BFamily with sequence similarity 89 member B. (189 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
MINK1Misshapen like kinase 1. (1342 aa)
ENSCPOP00000030705CYCLIN domain-containing protein; Belongs to the cyclin family. (341 aa)
ENSCPOP00000030815CAF1C_H4-bd domain-containing protein. (54 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CDC27Cell division cycle 27. (825 aa)
ANAPC15Anaphase promoting complex subunit 15. (134 aa)
HMGA1High mobility group AT-hook 1. (108 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
Scml1SAM domain-containing protein. (318 aa)
CBX7Chromobox 7. (228 aa)
UbcUncharacterized protein. (159 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (496 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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