STRINGSTRING
Ubc Ubc UBA52 UBA52 CDKN2B CDKN2B H0UX36_CAVPO H0UX36_CAVPO Rps27a Rps27a MDM4 MDM4 MAPK1 MAPK1 MOV10 MOV10 ETS2 ETS2 CDKN2A CDKN2A H0WAD6_CAVPO H0WAD6_CAVPO H0WDT2_CAVPO H0WDT2_CAVPO MDM2 MDM2 CDK4 CDK4 ETV3 ETV3 MAPK3 MAPK3 ENSCPOP00000025037 ENSCPOP00000025037 CDKN2C CDKN2C ID1 ID1 CDKN2D CDKN2D ETS1 ETS1 TP53 TP53 UBB UBB CDK6 CDK6 ENSCPOP00000031632 ENSCPOP00000031632
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UbcUncharacterized protein. (159 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
H0UX36_CAVPOETS domain-containing protein. (131 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (485 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
MOV10Mov10 RISC complex RNA helicase. (1063 aa)
ETS2ETS proto-oncogene 2, transcription factor. (447 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (134 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ETV3ETS variant 3. (515 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ENSCPOP00000025037ETS domain-containing protein. (144 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (151 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
ETS1ETS proto-oncogene 1, transcription factor. (441 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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