STRINGSTRING
P4HB P4HB EXOC6 EXOC6 EXOC2 EXOC2 FFAR4 FFAR4 ACE ACE CPA3 CPA3 CPB1 CPB1 MYRIP MYRIP ATP6AP2 ATP6AP2 ENPEP ENPEP CPB2 CPB2 SLC30A5 SLC30A5 DPP10 DPP10 BCHE BCHE GNB1 GNB1 ISL1 ISL1 EXOC3 EXOC3 PCSK2 PCSK2 PHEX PHEX PAX6 PAX6 CDX2 CDX2 SLC30A7 SLC30A7 FSHB FSHB MME MME Ctsd Ctsd SPCS3 SPCS3 MMEL1 MMEL1 ISL2 ISL2 GNG13 GNG13 PCSK1 PCSK1 MBOAT4 MBOAT4 EXOC6B EXOC6B Ces1d Ces1d EXOC3L1 EXOC3L1 TNFAIP2 TNFAIP2 PDIA2 PDIA2 EXOC5 EXOC5 SEC11C SEC11C FAP FAP CPA6 CPA6 CMA1 CMA1 LOC100733338 LOC100733338 LOC100721783 LOC100721783 ACE2 ACE2 Cltrn Cltrn CPE CPE H0VU94_CAVPO H0VU94_CAVPO KLF4 KLF4 GCG GCG GNAT3 GNAT3 INHA INHA LOC100712658 LOC100712658 H0VWU3_CAVPO H0VWU3_CAVPO Ffar1 Ffar1 GPR119 GPR119 H0W0R3_CAVPO H0W0R3_CAVPO REN REN CTSZ CTSZ KIF5C KIF5C GNB3 GNB3 Lhb Lhb GRP GRP LOC100735910 LOC100735910 GIP GIP H0W5Z7_CAVPO H0W5Z7_CAVPO LOC100714182 LOC100714182 H0W7M7_CAVPO H0W7M7_CAVPO ALX3 ALX3 EXOC8 EXOC8 GHRL GHRL POMC POMC EXOC3L2 EXOC3L2 DPP9 DPP9 AGT AGT EXOC4 EXOC4 Inhba Inhba LOC100717473 LOC100717473 EXOC7 EXOC7 PLA2G7 PLA2G7 ENSCPOP00000024925 ENSCPOP00000024925 INHBE INHBE TSHB TSHB DPP8 DPP8 SPCS1 SPCS1 ACHE ACHE EXOC1 EXOC1 DPP4 DPP4 INS INS SEC11A SEC11A SLC30A6 SLC30A6 LEP LEP AOPEP AOPEP SPCS2 SPCS2 GH1 GH1 LOC100721835 LOC100721835 DPP6 DPP6 ERO1B ERO1B INHBC INHBC EXOC3L4 EXOC3L4 IGF1 IGF1 SLC30A4 SLC30A4 INHBB INHBB LOC100730472 LOC100730472
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
P4HBProtein disulfide-isomerase. (509 aa)
EXOC6Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (804 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa)
FFAR4Free fatty acid receptor 4. (363 aa)
ACEAngiotensin-converting enzyme. (1302 aa)
CPA3Carboxypeptidase A3. (416 aa)
CPB1Carboxypeptidase B1. (416 aa)
MYRIPMyosin VIIA and Rab interacting protein. (830 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (350 aa)
ENPEPAminopeptidase. (898 aa)
CPB2Carboxypeptidase B2. (423 aa)
SLC30A5Solute carrier family 30 member 5. (766 aa)
DPP10Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family. (776 aa)
BCHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (602 aa)
GNB1Beta-transducin. (340 aa)
ISL1ISL LIM homeobox 1. (349 aa)
EXOC3Exocyst complex component 3. (755 aa)
PCSK2Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. (606 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (749 aa)
PAX6Paired box 6. (436 aa)
CDX2Caudal type homeobox 2. (314 aa)
SLC30A7Solute carrier family 30 member 7. (366 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (130 aa)
MMEMembrane metalloendopeptidase. (718 aa)
CtsdPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (407 aa)
SPCS3Signal peptidase complex subunit 3. (180 aa)
MMEL1Membrane metalloendopeptidase like 1. (772 aa)
ISL2ISL LIM homeobox 2. (358 aa)
GNG13G protein subunit gamma 13. (67 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1. (755 aa)
MBOAT4Membrane bound O-acyltransferase domain containing 4; Belongs to the membrane-bound acyltransferase family. (333 aa)
EXOC6BExocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (810 aa)
Ces1dCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
EXOC3L1Exocyst complex component 3 like 1. (773 aa)
TNFAIP2TNF alpha induced protein 2. (691 aa)
PDIA2Protein disulfide isomerase family A member 2. (528 aa)
EXOC5Exocyst complex component 5. (698 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (192 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (725 aa)
CPA6Carboxypeptidase A6. (438 aa)
CMA1Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. (247 aa)
LOC100733338Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (278 aa)
LOC100721783G_PROTEIN_RECEP_F1_2 domain-containing protein. (300 aa)
ACE2Angiotensin-converting enzyme. (794 aa)
CltrnCollectrin domain-containing protein. (222 aa)
CPECarboxypeptidase E. (476 aa)
H0VU94_CAVPOCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (520 aa)
KLF4Kruppel like factor 4. (469 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
INHAInhibin subunit alpha. (405 aa)
LOC100712658Angiotensin-converting enzyme. (718 aa)
H0VWU3_CAVPOAngiotensin-converting enzyme. (685 aa)
Ffar1annotation not available (300 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
H0W0R3_CAVPOHomeobox domain-containing protein. (134 aa)
RENRenin; Belongs to the peptidase A1 family. (403 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
GNB3G protein subunit beta 3. (340 aa)
LhbPutative luteinizing hormone beta subunit. (141 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family. (143 aa)
LOC100735910Angiotensin-converting enzyme. (706 aa)
GIPGastric inhibitory polypeptide. (145 aa)
H0W5Z7_CAVPOAngiotensin-converting enzyme. (622 aa)
LOC100714182Angiotensin-converting enzyme. (701 aa)
H0W7M7_CAVPOUncharacterized protein. (105 aa)
ALX3ALX homeobox 3. (343 aa)
EXOC8Exocyst complex component 8. (716 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
POMCCorticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. (342 aa)
EXOC3L2Exocyst complex component 3 like 2. (720 aa)
DPP9Dipeptidyl peptidase 9; Belongs to the peptidase S9B family. (863 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
EXOC4Exocyst complex component 4. (975 aa)
InhbaTGF_BETA_2 domain-containing protein. (133 aa)
LOC100717473Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (697 aa)
PLA2G7Platelet-activating factor acetylhydrolase; Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids; Belongs to the AB hydrolase superfamily. Lipase family. (436 aa)
ENSCPOP00000024925COesterase domain-containing protein. (295 aa)
INHBEInhibin subunit beta E. (352 aa)
TSHBThyroid stimulating hormone beta subunit. (138 aa)
DPP8Dipeptidyl peptidase 8; Belongs to the peptidase S9B family. (891 aa)
SPCS1Signal peptidase complex subunit 1. (102 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (613 aa)
EXOC1Exocyst complex component 1. (911 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (764 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (186 aa)
SLC30A6Solute carrier family 30 member 6. (461 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (165 aa)
AOPEPAminopeptidase O (putative). (723 aa)
SPCS2Signal peptidase complex subunit 2. (226 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. (244 aa)
LOC100721835Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
DPP6Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family. (864 aa)
ERO1BEndoplasmic reticulum oxidoreductase 1 beta. (471 aa)
INHBCInhibin subunit beta C. (352 aa)
EXOC3L4Exocyst complex component 3 like 4. (699 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
SLC30A4Solute carrier family 30 member 4. (366 aa)
INHBBInhibin subunit beta B. (374 aa)
LOC100730472Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (559 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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