56 items (Cavia porcellus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PSMD6	Proteasome 26S subunit, non-ATPase 6. (389 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
	PSMB8	Proteasome subunit beta. (273 aa)
	PSMB1	Proteasome subunit beta. (241 aa)
	PSMB6	Proteasome subunit beta. (239 aa)
	PSMB9	Proteasome subunit beta. (219 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (315 aa)
	Rps27a	Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
	PSMF1	Proteasome inhibitor subunit 1. (271 aa)
	PSMA5	Proteasome subunit alpha type. (241 aa)
	PSMA8	Proteasome subunit alpha type. (250 aa)
	PSME4	Proteasome activator subunit 4. (1827 aa)
	PSMB5	Proteasome subunit beta. (263 aa)
	PSMA7	Proteasome endopeptidase complex. (248 aa)
	Psmd10	ANK_REP_REGION domain-containing protein. (232 aa)
	PSMD3	Proteasome 26S subunit, non-ATPase 3. (534 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
	PSMA1	Proteasome subunit alpha type. (270 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
	H0VWS1_CAVPO	ANK_REP_REGION domain-containing protein. (213 aa)
	Psmd9	PDZ domain-containing protein. (223 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	PSMB3	Proteasome subunit beta. (207 aa)
	PSMB11	Proteasome subunit beta. (297 aa)
	PSMD5	Proteasome 26S subunit, non-ATPase 5. (504 aa)
	H0WAD6_CAVPO	Ubiquitin-like domain-containing protein. (111 aa)
	PSMB10	Proteasome subunit beta. (273 aa)
	H0WDT2_CAVPO	Ubiquitin-like domain-containing protein. (127 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	ENSCPOP00000023065	ANK_REP_REGION domain-containing protein. (179 aa)
	PSME1	Proteasome activator subunit 1. (249 aa)
	PSMC3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
	PSMD2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
	COP1	COP1 E3 ubiquitin ligase. (798 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (310 aa)
	PSMD4	Proteasome 26S subunit, non-ATPase 4. (377 aa)
	PSMD12	Proteasome 26S subunit, non-ATPase 12. (456 aa)
	PSMB2	Proteasome subunit beta. (201 aa)
	PSMA6	Proteasome subunit alpha type. (246 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
	UBB	Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
	PSMC1	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
	ENSCPOP00000031632	Ubiquitin-like domain-containing protein. (141 aa)
	PSME2	Proteasome activator subunit 2. (239 aa)
	Ubc	Uncharacterized protein. (159 aa)
	Psma2	Proteasome subunit alpha type. (234 aa)
	PSME3	Proteasome activator subunit 3. (254 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
	PSMD7	Proteasome 26S subunit, non-ATPase 7. (322 aa)
	PSMD8	Proteasome 26S subunit, non-ATPase 8. (350 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa)
	PSMD11	Proteasome 26S subunit, non-ATPase 11. (422 aa)
	PSMC6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
	PSMB7	Proteasome subunit beta. (277 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	COP1	ENSCPOP00000009885	ENSCPOP00000027044	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	COP1 E3 ubiquitin ligase.	0.758
ATM	PSMD14	ENSCPOP00000009885	ENSCPOP00000027971	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Proteasome 26S subunit, non-ATPase 14.	0.491
ATM	PSMD7	ENSCPOP00000009885	ENSCPOP00000009979	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Proteasome 26S subunit, non-ATPase 7.	0.401
ATM	TP53	ENSCPOP00000009885	ENSCPOP00000029751	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.997
ATM	UBB	ENSCPOP00000009885	ENSCPOP00000029946	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.655
ATM	Ubc	ENSCPOP00000009885	ENSCPOP00000031925	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.666
COP1	ATM	ENSCPOP00000027044	ENSCPOP00000009885	COP1 E3 ubiquitin ligase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.758
COP1	ENSCPOP00000023065	ENSCPOP00000027044	ENSCPOP00000023065	COP1 E3 ubiquitin ligase.	ANK_REP_REGION domain-containing protein.	0.533
COP1	ENSCPOP00000031632	ENSCPOP00000027044	ENSCPOP00000031632	COP1 E3 ubiquitin ligase.	Ubiquitin-like domain-containing protein.	0.683
COP1	H0VWS1_CAVPO	ENSCPOP00000027044	ENSCPOP00000015149	COP1 E3 ubiquitin ligase.	ANK_REP_REGION domain-containing protein.	0.533
COP1	H0WAD6_CAVPO	ENSCPOP00000027044	ENSCPOP00000019948	COP1 E3 ubiquitin ligase.	Ubiquitin-like domain-containing protein.	0.683
COP1	H0WDT2_CAVPO	ENSCPOP00000027044	ENSCPOP00000021155	COP1 E3 ubiquitin ligase.	Ubiquitin-like domain-containing protein.	0.664
COP1	PSMC1	ENSCPOP00000027044	ENSCPOP00000031413	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family.	0.568
COP1	PSMC2	ENSCPOP00000027044	ENSCPOP00000014950	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family.	0.568
COP1	PSMC4	ENSCPOP00000027044	ENSCPOP00000003561	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.	0.528
COP1	PSMC5	ENSCPOP00000027044	ENSCPOP00000010226	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family.	0.568
COP1	PSMD14	ENSCPOP00000027044	ENSCPOP00000027971	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, non-ATPase 14.	0.565
COP1	PSMD7	ENSCPOP00000027044	ENSCPOP00000009979	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, non-ATPase 7.	0.557
COP1	PSME4	ENSCPOP00000027044	ENSCPOP00000010698	COP1 E3 ubiquitin ligase.	Proteasome activator subunit 4.	0.573
COP1	Psmd10	ENSCPOP00000027044	ENSCPOP00000013582	COP1 E3 ubiquitin ligase.	ANK_REP_REGION domain-containing protein.	0.533