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GNG11 GNG11 GNB4 GNB4 MAP3K7 MAP3K7 ROR1 ROR1 GNG12 GNG12 Gng5 Gng5 CLTB CLTB GNG8 GNG8 PSMD14 PSMD14 NLK NLK PSMD4 PSMD4 FHDC1 FHDC1 PSMD12 PSMD12 GNG4 GNG4 PSMB2 PSMB2 PFN1 PFN1 PSMA6 PSMA6 FZD2 FZD2 UBB UBB SYNPO SYNPO FZD5 FZD5 ENSCPOP00000030509 ENSCPOP00000030509 CLTA CLTA MAP3K20 MAP3K20 RHOA RHOA GNGT2 GNGT2 PSMC1 PSMC1 ENSCPOP00000031524 ENSCPOP00000031524 ENSCPOP00000031632 ENSCPOP00000031632 ROR2 ROR2 WNT5B WNT5B PSME2 PSME2 Ubc Ubc PPP3R1 PPP3R1 DAAM2 DAAM2 Psma2 Psma2 PSME3 PSME3 WNT4 WNT4 ARRB2 ARRB2 CTNNB1 CTNNB1 ENSCPOP00000033061 ENSCPOP00000033061 SMURF1 SMURF1 UBA52 UBA52 PSMB8 PSMB8 PSMB1 PSMB1 PRICKLE2 PRICKLE2 PSMB6 PSMB6 PDE6A PDE6A PSMB9 PSMB9 PRKCB PRKCB PSMD13 PSMD13 PSMC4 PSMC4 NFATC1 NFATC1 PDE6C PDE6C AP2A1 AP2A1 CLTC CLTC GNB1 GNB1 PRICKLE1 PRICKLE1 Rps27a Rps27a PSMD6 PSMD6 CAMK2A CAMK2A DVL1 DVL1 PSMB7 PSMB7 PPP3CB PPP3CB GNGT1 GNGT1 WNT11 WNT11 PSMC6 PSMC6 PSMD11 PSMD11 PPP3CA PPP3CA FZD3 FZD3 WDR92 WDR92 GNG13 GNG13 Ap2b1 Ap2b1 PARD6A PARD6A PSMD8 PSMD8 AP2A2 AP2A2 PSMD7 PSMD7 PSMC5 PSMC5 Gnat2 Gnat2 PSME4 PSME4 PSMA8 PSMA8 FZD6 FZD6 NFAT5 NFAT5 GNB5 GNB5 PSMA5 PSMA5 PSMF1 PSMF1 RAC3 RAC3 PSMB5 PSMB5 PSMA7 PSMA7 FZD4 FZD4 TCF7L1 TCF7L1 MOV10 MOV10 PRKCA PRKCA Psmd10 Psmd10 PSMD3 PSMD3 PSMB4 PSMB4 PSMA1 PSMA1 RAC2 RAC2 PSMC2 PSMC2 WNT1 WNT1 H0VWS1_CAVPO H0VWS1_CAVPO FZD7 FZD7 GNB2 GNB2 Prickle4 Prickle4 PDE6B PDE6B GNB3 GNB3 Psmd9 Psmd9 PDE6G PDE6G PSMA4 PSMA4 FZD1 FZD1 DVL2 DVL2 AP2S1 AP2S1 PSMB3 PSMB3 PSMB11 PSMB11 PSMD5 PSMD5 H0WAD6_CAVPO H0WAD6_CAVPO H0WBW4_CAVPO H0WBW4_CAVPO PSMB10 PSMB10 TCF7 TCF7 PRICKLE3 PRICKLE3 H0WDT2_CAVPO H0WDT2_CAVPO PSMD1 PSMD1 DAAM1 DAAM1 RAC1 RAC1 GNG3 GNG3 TCF7L2 TCF7L2 PSMA3 PSMA3 DVL3 DVL3 AP2M1 AP2M1 GNG7 GNG7 ENSCPOP00000023065 ENSCPOP00000023065 PSME1 PSME1 WNT5A WNT5A LEF1 LEF1 ENSCPOP00000023932 ENSCPOP00000023932 PDE6H PDE6H PRKCG PRKCG PSMC3 PSMC3 GNG2 GNG2 SMURF2 SMURF2 GNAO1 GNAO1 PSMD2 PSMD2 CLTCL1 CLTCL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNB4G protein subunit beta 4. (340 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (931 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
Gng5G protein gamma domain-containing protein. (41 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
FHDC1FH2 domain containing 1. (1055 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PSMB2Proteasome subunit beta. (201 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
SYNPOSynaptopodin. (937 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
ENSCPOP00000030509Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (242 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (711 aa)
RHOARas homolog family member A. (193 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
ENSCPOP00000031524Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (100 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (939 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
PSME2Proteasome activator subunit 2. (239 aa)
UbcUncharacterized protein. (159 aa)
PPP3R1Uncharacterized protein. (169 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1083 aa)
Psma2Proteasome subunit alpha type. (234 aa)
PSME3Proteasome activator subunit 3. (254 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
ARRB2Arrestin beta 2. (417 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSCPOP00000033061AP complex subunit beta. (889 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
PSMB8Proteasome subunit beta. (273 aa)
PSMB1Proteasome subunit beta. (241 aa)
PRICKLE2Prickle planar cell polarity protein 2. (901 aa)
PSMB6Proteasome subunit beta. (239 aa)
PDE6APhosphodiesterase. (860 aa)
PSMB9Proteasome subunit beta. (219 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (315 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
NFATC1Nuclear factor of activated T cells 1. (928 aa)
PDE6CPhosphodiesterase. (862 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
GNB1Beta-transducin. (340 aa)
PRICKLE1Prickle planar cell polarity protein 1. (832 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
DVL1Dishevelled segment polarity protein 1. (698 aa)
PSMB7Proteasome subunit beta. (277 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PPP3CASerine/threonine-protein phosphatase. (518 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WDR92WD repeat domain 92. (357 aa)
GNG13G protein subunit gamma 13. (67 aa)
Ap2b1AP complex subunit beta. (951 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (937 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
Gnat2Uncharacterized protein. (354 aa)
PSME4Proteasome activator subunit 4. (1827 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
NFAT5Nuclear factor of activated T cells 5. (1485 aa)
GNB5G protein subunit beta 5. (406 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
RAC3Rac family small GTPase 3. (192 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
MOV10Mov10 RISC complex RNA helicase. (1063 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
Psmd10ANK_REP_REGION domain-containing protein. (232 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
PSMA1Proteasome subunit alpha type. (270 aa)
RAC2Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). (192 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
H0VWS1_CAVPOANK_REP_REGION domain-containing protein. (213 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
GNB2G protein subunit beta 2. (378 aa)
Prickle4Uncharacterized protein. (316 aa)
PDE6BPhosphodiesterase. (854 aa)
GNB3G protein subunit beta 3. (340 aa)
Psmd9PDZ domain-containing protein. (223 aa)
PDE6GRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones (By similarity). (87 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (634 aa)
DVL2Dishevelled segment polarity protein 2. (737 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (148 aa)
PSMB3Proteasome subunit beta. (207 aa)
PSMB11Proteasome subunit beta. (297 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
H0WBW4_CAVPOGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PSMB10Proteasome subunit beta. (273 aa)
TCF7Transcription factor 7. (262 aa)
PRICKLE3Prickle planar cell polarity protein 3. (514 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
DAAM1Dishevelled associated activator of morphogenesis 1. (1077 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
TCF7L2Transcription factor 7 like 2. (350 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
DVL3Dishevelled segment polarity protein 3. (717 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
ENSCPOP00000023065ANK_REP_REGION domain-containing protein. (179 aa)
PSME1Proteasome activator subunit 1. (249 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LEF1Lymphoid enhancer binding factor 1. (396 aa)
ENSCPOP00000023932Uncharacterized protein. (332 aa)
PDE6HPhosphodiesterase 6H. (83 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
SMURF2E3 ubiquitin-protein ligase. (782 aa)
GNAO1G protein subunit alpha o1. (318 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1676 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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