56 items (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Prkaca	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	ARRB2	Arrestin beta 2. (417 aa)
	GRK2	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (750 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	GPR20	G protein-coupled receptor 20; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	PDE1A	Phosphodiesterase. (531 aa)
	GPR85	G protein-coupled receptor 85. (370 aa)
	MC1R	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (316 aa)
	PDE8A	Phosphodiesterase. (826 aa)
	PTHLH	Parathyroid hormone like hormone. (176 aa)
	ENSCPOP00000030509	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	ENSCPOP00000030527	Uncharacterized protein. (111 aa)
	PDE7B	Phosphodiesterase. (502 aa)
	Pde11a	Phosphodiesterase. (888 aa)
	Pde8b	Phosphodiesterase. (785 aa)
	PRKAR2A	Protein kinase cAMP-dependent type II regulatory subunit alpha. (395 aa)
	PRKAR2B	Protein kinase cAMP-dependent type II regulatory subunit beta. (350 aa)
	VIP	Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (171 aa)
	THAP7	THAP domain containing 7. (309 aa)
	GRK6	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (578 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
	GRK5	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1102 aa)
	GPR52	G protein-coupled receptor 52; Belongs to the G-protein coupled receptor 1 family. (263 aa)
	PDE7A	Phosphodiesterase. (482 aa)
	GRK3	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (673 aa)
	PDE3A	Phosphodiesterase. (1132 aa)
	FAP	Fibroblast activation protein alpha; Belongs to the peptidase S9B family. (725 aa)
	FN1	Fibronectin 1. (2478 aa)
	PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
	RLN3	Relaxin 3. (146 aa)
	GPR173	G protein-coupled receptor 173. (373 aa)
	PDE3B	Phosphodiesterase. (931 aa)
	PDE1B	Phosphodiesterase. (535 aa)
	PDE4A	cAMP-specific 3',5'-cyclic phosphodiesterase 4A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. (863 aa)
	Gpr25	G_PROTEIN_RECEP_F1_2 domain-containing protein. (202 aa)
	ADRB2	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (418 aa)
	SHC1	SHC adaptor protein 1. (583 aa)
	GPR32	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	MC3R	Melanocortin 3 receptor. (324 aa)
	GPR15	G protein-coupled receptor 15; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	GPR63	G protein-coupled receptor 63. (419 aa)
	Gpr150	Uncharacterized protein. (388 aa)
	PDE4D	Phosphodiesterase. (782 aa)
	GPR176	G protein-coupled receptor 176. (512 aa)
	ENSCPOP00000022086	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (593 aa)
	GPR83	G protein-coupled receptor 83; Belongs to the G-protein coupled receptor 1 family. (423 aa)
	CNBD2	Cyclic nucleotide binding domain containing 2. (587 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
	ARRB1	Arrestin beta 1. (430 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
	GPR45	G protein-coupled receptor 45. (372 aa)
	FAM83G	Family with sequence similarity 83 member G. (819 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	PDE2A	Phosphodiesterase. (950 aa)
	PDE10A	Phosphodiesterase. (773 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRB2	ARRB1	ENSCPOP00000018242	ENSCPOP00000024897	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Arrestin beta 1.	0.883
ADRB2	ARRB2	ENSCPOP00000018242	ENSCPOP00000032723	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Arrestin beta 2.	0.936
ADRB2	DRD1	ENSCPOP00000018242	ENSCPOP00000025180	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	0.476
ADRB2	ENSCPOP00000030509	ENSCPOP00000018242	ENSCPOP00000030509	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.535
ADRB2	ENSCPOP00000030527	ENSCPOP00000018242	ENSCPOP00000030527	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Uncharacterized protein.	0.767
ADRB2	FAP	ENSCPOP00000018242	ENSCPOP00000010793	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	0.632
ADRB2	GNG2	ENSCPOP00000018242	ENSCPOP00000024690	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.699
ADRB2	GRK2	ENSCPOP00000018242	ENSCPOP00000032542	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.785
ADRB2	GRK3	ENSCPOP00000018242	ENSCPOP00000008791	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.735
ADRB2	GRK5	ENSCPOP00000018242	ENSCPOP00000006722	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.695
ADRB2	GRK6	ENSCPOP00000018242	ENSCPOP00000003649	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.718
ADRB2	PDE4A	ENSCPOP00000018242	ENSCPOP00000014895	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	cAMP-specific 3',5'-cyclic phosphodiesterase 4A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.	0.423
ADRB2	PRKACB	ENSCPOP00000018242	ENSCPOP00000026584	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.511
ADRB2	Prkaca	ENSCPOP00000018242	ENSCPOP00000032930	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.511
ADRB2	VIP	ENSCPOP00000018242	ENSCPOP00000002714	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family.	0.778
ARRB1	ADRB2	ENSCPOP00000024897	ENSCPOP00000018242	Arrestin beta 1.	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.	0.883
ARRB1	ARRB2	ENSCPOP00000024897	ENSCPOP00000032723	Arrestin beta 1.	Arrestin beta 2.	0.970
ARRB1	DRD1	ENSCPOP00000024897	ENSCPOP00000025180	Arrestin beta 1.	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	0.605
ARRB1	GPR32	ENSCPOP00000024897	ENSCPOP00000019124	Arrestin beta 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.428
ARRB1	GRK2	ENSCPOP00000024897	ENSCPOP00000032542	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.945