node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACHE | GHRL | ENSCPOP00000026437 | ENSCPOP00000019867 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Ghrelin and obestatin prepropeptide. | 0.655 |
BCHE | GHRL | ENSCPOP00000004499 | ENSCPOP00000019867 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Ghrelin and obestatin prepropeptide. | 0.719 |
FAP | GCG | ENSCPOP00000010793 | ENSCPOP00000014570 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | 0.740 |
FAP | GHRL | ENSCPOP00000010793 | ENSCPOP00000019867 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | Ghrelin and obestatin prepropeptide. | 0.709 |
FAP | INS | ENSCPOP00000010793 | ENSCPOP00000026989 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.624 |
FAP | LEP | ENSCPOP00000010793 | ENSCPOP00000029200 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.692 |
FAP | PCSK1 | ENSCPOP00000010793 | ENSCPOP00000009200 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | Proprotein convertase subtilisin/kexin type 1. | 0.631 |
FAP | SEC11A | ENSCPOP00000010793 | ENSCPOP00000028660 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | Signal peptidase complex catalytic subunit SEC11. | 0.604 |
FAP | SEC11C | ENSCPOP00000010793 | ENSCPOP00000010727 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | Signal peptidase complex catalytic subunit SEC11. | 0.604 |
GCG | FAP | ENSCPOP00000014570 | ENSCPOP00000010793 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | 0.740 |
GCG | GHRL | ENSCPOP00000014570 | ENSCPOP00000019867 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | Ghrelin and obestatin prepropeptide. | 0.904 |
GCG | INS | ENSCPOP00000014570 | ENSCPOP00000026989 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.836 |
GCG | LEP | ENSCPOP00000014570 | ENSCPOP00000029200 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.887 |
GCG | PCSK1 | ENSCPOP00000014570 | ENSCPOP00000009200 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | Proprotein convertase subtilisin/kexin type 1. | 0.797 |
GCG | SEC11A | ENSCPOP00000014570 | ENSCPOP00000028660 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | Signal peptidase complex catalytic subunit SEC11. | 0.604 |
GCG | SEC11C | ENSCPOP00000014570 | ENSCPOP00000010727 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | Signal peptidase complex catalytic subunit SEC11. | 0.604 |
GH1 | GHRL | ENSCPOP00000030591 | ENSCPOP00000019867 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Ghrelin and obestatin prepropeptide. | 0.935 |
GH1 | INS | ENSCPOP00000030591 | ENSCPOP00000026989 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.405 |
GH1 | LEP | ENSCPOP00000030591 | ENSCPOP00000029200 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.930 |
GHRL | ACHE | ENSCPOP00000019867 | ENSCPOP00000026437 | Ghrelin and obestatin prepropeptide. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.655 |