STRINGSTRING
PAK1 PAK1 NCF1 NCF1 PXN PXN VAV3 VAV3 PIK3CB PIK3CB PTK2 PTK2 SHE SHE NCF4 NCF4 CYBB CYBB MLST8 MLST8 ELMO2 ELMO2 PRKCB PRKCB PDPK1 PDPK1 FNDC3A FNDC3A WASF1 WASF1 NOS3 NOS3 RNF222 RNF222 TRIB3 TRIB3 ACTL7A ACTL7A Shc4 Shc4 PIK3CA PIK3CA CRK CRK ABI2 ABI2 PIK3R1 PIK3R1 RASA1 RASA1 AXL AXL SHD SHD NCKAP1L NCKAP1L NCF2 NCF2 KDR KDR WASF3 WASF3 ROCK1 ROCK1 NRAS NRAS KRAS KRAS ELMO3 ELMO3 Itgb3 Itgb3 MTOR MTOR FNDC3B FNDC3B LPXN LPXN SPHK1 SPHK1 ROCK2 ROCK2 STX12 STX12 ABI1 ABI1 ARVCF ARVCF MAPK13 MAPK13 MAPK12 MAPK12 PRKCA PRKCA ITGAV ITGAV DOCK1 DOCK1 AKT3 AKT3 NCK2 NCK2 ACTRT2 ACTRT2 NCKAP1 NCKAP1 PLCG1 PLCG1 CYBA CYBA MAPKAPK2 MAPKAPK2 H0W027_CAVPO H0W027_CAVPO Shb Shb LOC100723025 LOC100723025 ACTL7B ACTL7B ACTRT1 ACTRT1 LOC100731872 LOC100731872 ACTL9 ACTL9 CASS4 CASS4 ACTL8 ACTL8 EFS EFS SH2D2A SH2D2A MAPKAPK3 MAPKAPK3 CYFIP2 CYFIP2 ACTB ACTB RAC1 RAC1 MAPK14 MAPK14 ELMO1 ELMO1 NCK1 NCK1 PAK2 PAK2 CTNND1 CTNND1 WASF2 WASF2 VAV2 VAV2 PAK3 PAK3 MAPK11 MAPK11 CYFIP1 CYFIP1 FYN FYN SHF SHF RICTOR RICTOR PRKCD PRKCD AKT1 AKT1 PRKACB PRKACB Vegfa Vegfa TGFB1I1 TGFB1I1 BCAR1 BCAR1 PRR5 PRR5 CAV1 CAV1 STX7 STX7 MAPKAP1 MAPKAP1 BRK1 BRK1 PTK2B PTK2B ACTG1 ACTG1 NEDD9 NEDD9 CDH5 CDH5 RHOA RHOA JUP JUP AKT2 AKT2 CDC42 CDC42 Hsh2d Hsh2d CSDE1 CSDE1 BAIAP2 BAIAP2 HSPB1 HSPB1 CTNNB1 CTNNB1 HRAS HRAS Prkaca Prkaca
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAK1Non-specific serine/threonine protein kinase. (544 aa)
NCF1Neutrophil cytosolic factor 1. (401 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (588 aa)
VAV3Vav guanine nucleotide exchange factor 3. (779 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
SHESrc homology 2 domain containing E. (467 aa)
NCF4Neutrophil cytosolic factor 4. (346 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (550 aa)
FNDC3AFibronectin type III domain containing 3A. (1172 aa)
WASF1WASP family member 1. (559 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1206 aa)
RNF222Ring finger protein 222. (215 aa)
TRIB3Tribbles pseudokinase 3. (308 aa)
ACTL7AActin like 7A; Belongs to the actin family. (440 aa)
Shc4Uncharacterized protein. (372 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
CRKCRK proto-oncogene, adaptor protein. (281 aa)
ABI2Abl interactor 2. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RASA1RAS p21 protein activator 1. (1024 aa)
AXLAXL receptor tyrosine kinase. (888 aa)
SHDSrc homology 2 domain containing transforming protein D. (345 aa)
NCKAP1LNCK associated protein 1 like. (1111 aa)
NCF2Neutrophil cytosolic factor 2. (513 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
WASF3WASP family member 3. (502 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ELMO3Engulfment and cell motility 3. (720 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (735 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
FNDC3BFibronectin type III domain containing 3B. (1101 aa)
LPXNLeupaxin. (381 aa)
SPHK1Sphingosine kinase 1. (386 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1371 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (274 aa)
ABI1Abl interactor 1. (474 aa)
ARVCFARVCF delta catenin family member. (962 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (963 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1865 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
NCK2Cytoplasmic protein. (377 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (376 aa)
NCKAP1NCK associated protein 1. (1140 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (189 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
ShbSH2 domain-containing protein. (479 aa)
LOC100723025Uncharacterized protein. (431 aa)
ACTL7BActin like 7B; Belongs to the actin family. (412 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (377 aa)
LOC100731872Uncharacterized protein; Belongs to the actin family. (1226 aa)
ACTL9Actin like 9; Belongs to the actin family. (388 aa)
CASS4Cas scaffold protein family member 4. (792 aa)
ACTL8Actin like 8; Belongs to the actin family. (371 aa)
EFSEmbryonal Fyn-associated substrate. (557 aa)
SH2D2ASH2 domain containing 2A. (328 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (380 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1269 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
NCK1Cytoplasmic protein. (377 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
CTNND1Catenin delta 1. (966 aa)
WASF2WASP family member 2. (497 aa)
VAV2Vav guanine nucleotide exchange factor 2. (807 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
MAPK11Mitogen-activated protein kinase. (385 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1264 aa)
FYNTyrosine-protein kinase. (537 aa)
SHFSrc homology 2 domain containing F. (412 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1471 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
VegfaVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (186 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (879 aa)
PRR5Proline rich 5. (358 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (278 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ACTG1Actin gamma 1. (375 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (747 aa)
RHOARas homolog family member A. (193 aa)
JUPJunction plakoglobin. (745 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CDC42Cell division cycle 42. (191 aa)
Hsh2dSH2 domain-containing protein. (356 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
BAIAP2BAI1 associated protein 2. (535 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (200 aa)
CTNNB1Catenin beta 1. (781 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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