STRINGSTRING
MYOF MYOF DYSF DYSF TPM1 TPM1 GUCY1A1 GUCY1A1 ACTA2 ACTA2 LPXN LPXN CACNA1I CACNA1I CACNA1H CACNA1H Tpm4 Tpm4 ITGA1 ITGA1 MYL9 MYL9 MYLK MYLK GUCY1B1 GUCY1B1 TRIM72 TRIM72 TLNRD1 TLNRD1 CALD1 CALD1 CACNA1G CACNA1G MYL10 MYL10 ANXA6 ANXA6 PAK2 PAK2 ENSCPOP00000022864 ENSCPOP00000022864 TLN2 TLN2 LMOD1 LMOD1 ENSCPOP00000024624 ENSCPOP00000024624 MYL6B MYL6B TPM3 TPM3 TPM2 TPM2 TGFB1I1 TGFB1I1 Aldh2 Aldh2 SORBS2 SORBS2 MYL12A MYL12A VCL VCL CAV3 CAV3 MYL6 MYL6 ENSCPOP00000031664 ENSCPOP00000031664 ACTG2 ACTG2 MYLPF MYLPF SORBS1 SORBS1 SORBS3 SORBS3 PXN PXN TLN1 TLN1 GUCY1A2 GUCY1A2 PAK1 PAK1 RNF222 RNF222 FER1L5 FER1L5 MYH11 MYH11 PDE5A PDE5A ITGB5 ITGB5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYOFMyoferlin. (2033 aa)
DYSFDysferlin. (2103 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (288 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
LPXNLeupaxin. (381 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2067 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2337 aa)
Tpm4Uncharacterized protein; Belongs to the tropomyosin family. (248 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1168 aa)
MYL9Myosin light chain 9. (172 aa)
MYLKMyosin light chain kinase. (1959 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (622 aa)
TRIM72Tripartite motif containing 72. (477 aa)
TLNRD1Talin rod domain containing 1. (355 aa)
CALD1Caldesmon 1. (742 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2372 aa)
MYL10Myosin light chain 10. (147 aa)
ANXA6Annexin. (753 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
ENSCPOP00000022864I-set domain-containing protein. (610 aa)
TLN2Talin 2. (2542 aa)
LMOD1Leiomodin 1. (595 aa)
ENSCPOP00000024624Uncharacterized protein. (493 aa)
MYL6BMyosin light chain 6B. (207 aa)
TPM3Tropomyosin 3; Belongs to the tropomyosin family. (285 aa)
TPM2Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
Aldh2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (521 aa)
SORBS2Sorbin and SH3 domain containing 2. (1204 aa)
MYL12AMyosin light chain 12A. (178 aa)
VCLVinculin. (1134 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
MYL6Myosin light chain 6. (151 aa)
ENSCPOP00000031664Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (702 aa)
ACTG2Actin gamma 2, smooth muscle. (376 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (170 aa)
SORBS1Sorbin and SH3 domain containing 1. (933 aa)
SORBS3Sorbin and SH3 domain containing 3. (685 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (588 aa)
TLN1Talin 1. (2537 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (635 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
RNF222Ring finger protein 222. (215 aa)
FER1L5Fer-1 like family member 5. (2020 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1982 aa)
PDE5APhosphodiesterase. (863 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (801 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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