STRINGSTRING
ENSCPOP00000023362 ENSCPOP00000023362 IL33 IL33 IL1R2 IL1R2 TONSL TONSL PELI2 PELI2 IRAK1 IRAK1 ENSCPOP00000032088 ENSCPOP00000032088 CHUK CHUK Ubc Ubc MAP3K3 MAP3K3 ENSCPOP00000031632 ENSCPOP00000031632 IL1RN IL1RN PTPN21 PTPN21 ENSCPOP00000031348 ENSCPOP00000031348 IL1RL2 IL1RL2 NKIRAS2 NKIRAS2 ENSCPOP00000030838 ENSCPOP00000030838 MAP3K20 MAP3K20 IL1R1 IL1R1 IL1RL1 IL1RL1 ENSCPOP00000030352 ENSCPOP00000030352 CASP8 CASP8 PELI1 PELI1 PELI3 PELI3 UBB UBB LOC100735260 LOC100735260 ENSCPOP00000029546 ENSCPOP00000029546 NLRX1 NLRX1 ENSCPOP00000029251 ENSCPOP00000029251 GSDMD GSDMD UBA52 UBA52 Usp18 Usp18 AGER AGER IRAK2 IRAK2 IRAK4 IRAK4 IL1B IL1B MAP3K2 MAP3K2 IL18 IL18 LRRC71 LRRC71 VWC2 VWC2 TAB3 TAB3 TRAF6 TRAF6 NFKB2 NFKB2 IL18BP IL18BP ENSCPOP00000023505 ENSCPOP00000023505 SQSTM1 SQSTM1 USP14 USP14 Hmgb1 Hmgb1 NKIRAS1 NKIRAS1 MAPK8 MAPK8 SIGIRR SIGIRR MAP3K7 MAP3K7 LOC100734419 LOC100734419 RBX1 RBX1 STAT3 STAT3 LOC100735813 LOC100735813 LOC100712719 LOC100712719 TRAF2 TRAF2 PTPN14 PTPN14 S100B S100B TIFA TIFA CASP12 CASP12 ENSCPOP00000027005 ENSCPOP00000027005 LRRC74B LRRC74B TOLLIP TOLLIP MAP2K6 MAP2K6 ENSCPOP00000023262 ENSCPOP00000023262 IRAK3 IRAK3 SKP1 SKP1 NFKBIA NFKBIA BTRC BTRC Rps27a Rps27a NFKB1 NFKB1 IL1F10 IL1F10 ALPK1 ALPK1 IL36RN IL36RN IKBKB IKBKB TBK1 TBK1 NLRC5 NLRC5 LRRC74A LRRC74A LRRC34 LRRC34 PTPN5 PTPN5 LOC100733338 LOC100733338 LOC106026468 LOC106026468 NFKBIB NFKBIB IL1RAPL1 IL1RAPL1 LRRC45 LRRC45 IL18RAP IL18RAP UBE2V1 UBE2V1 TAB2 TAB2 MFSD1 MFSD1 LRRC14 LRRC14 CASP10 CASP10 IL1RAP IL1RAP RELA RELA H0W0A7_CAVPO H0W0A7_CAVPO CUL1 CUL1 IL1A IL1A IL18R1 IL18R1 N4BP1 N4BP1 MYD88 MYD88 KHNYN KHNYN IL13 IL13 H0WAD6_CAVPO H0WAD6_CAVPO H0WAS6_CAVPO H0WAS6_CAVPO IKBKG IKBKG TAB1 TAB1 H0WC40_CAVPO H0WC40_CAVPO PTPN23 PTPN23 APP APP H0WDT2_CAVPO H0WDT2_CAVPO LOC100725217 LOC100725217 LOC100718750 LOC100718750
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCPOP00000023362UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
IL33Interleukin 33. (280 aa)
IL1R2Interleukin 1 receptor type 2. (440 aa)
TONSLTonsoku like, DNA repair protein. (1395 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
ENSCPOP00000032088Uncharacterized protein. (191 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
UbcUncharacterized protein. (159 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
IL1RNInterleukin-1. (176 aa)
PTPN21Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1166 aa)
ENSCPOP00000031348Interleukin-1. (182 aa)
IL1RL2Interleukin 1 receptor like 2. (578 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
ENSCPOP00000030838UBIQUITIN_CONJUGAT_2 domain-containing protein. (133 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (711 aa)
IL1R1Interleukin 1 receptor type 1. (572 aa)
IL1RL1Interleukin 1 receptor like 1. (558 aa)
ENSCPOP00000030352Uncharacterized protein. (97 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (481 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
LOC100735260Interleukin-1. (160 aa)
ENSCPOP00000029546UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa)
NLRX1NLR family member X1. (976 aa)
ENSCPOP00000029251Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
GSDMDGasdermin D. (481 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
Usp18USP domain-containing protein; Belongs to the peptidase C19 family. (158 aa)
AGERAdvanced glycosylation end-product specific receptor. (377 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (606 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (462 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (586 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (189 aa)
LRRC71Leucine rich repeat containing 71. (548 aa)
VWC2Von Willebrand factor C domain containing 2. (315 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (679 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
NFKB2Nuclear factor kappa B subunit 2. (854 aa)
IL18BPInterleukin 18 binding protein. (203 aa)
ENSCPOP00000023505Interleukin-1. (182 aa)
SQSTM1Sequestosome 1. (415 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (493 aa)
Hmgb1annotation not available (215 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SIGIRRSingle Ig and TIR domain containing. (408 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LOC100734419Interleukin-1. (150 aa)
RBX1Ring-box 1. (108 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LOC100735813Interleukin-1. (160 aa)
LOC100712719Interleukin-1. (163 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
PTPN14Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1182 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
TIFATRAF interacting protein with forkhead associated domain. (185 aa)
CASP12Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (400 aa)
ENSCPOP00000027005UBIQUITIN_CONJUGAT_2 domain-containing protein. (83 aa)
LRRC74BLeucine rich repeat containing 74B. (380 aa)
TOLLIPToll interacting protein. (274 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ENSCPOP00000023262Interleukin-1. (137 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (576 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (162 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (582 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
NFKB1Nuclear factor kappa B subunit 1. (967 aa)
IL1F10Interleukin-1. (149 aa)
ALPK1Alpha kinase 1. (1117 aa)
IL36RNInterleukin-1. (156 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
TBK1TANK binding kinase 1. (729 aa)
NLRC5NLR family CARD domain containing 5. (1831 aa)
LRRC74ALeucine rich repeat containing 74A. (465 aa)
LRRC34Leucine rich repeat containing 34. (448 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (541 aa)
LOC100733338Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (278 aa)
LOC106026468UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
NFKBIBNFKB inhibitor beta. (355 aa)
IL1RAPL1Interleukin 1 receptor accessory protein like 1. (696 aa)
LRRC45Leucine rich repeat containing 45. (669 aa)
IL18RAPInterleukin 18 receptor accessory protein. (564 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (145 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (665 aa)
MFSD1Major facilitator superfamily domain containing 1. (456 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (474 aa)
IL1RAPInterleukin 1 receptor accessory protein. (685 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
H0W0A7_CAVPOUncharacterized protein. (174 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (272 aa)
IL18R1Interleukin 18 receptor 1. (481 aa)
N4BP1NEDD4 binding protein 1. (886 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (294 aa)
KHNYNKH and NYN domain containing. (657 aa)
IL13Interleukin 13. (136 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
H0WAS6_CAVPOUncharacterized protein. (214 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (507 aa)
H0WC40_CAVPOUncharacterized protein. (199 aa)
PTPN23Protein tyrosine phosphatase non-receptor type 23. (1623 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
LOC100725217Uncharacterized protein; Belongs to the peptidase C14A family. (361 aa)
LOC100718750Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (133 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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