STRINGSTRING
CASP12 CASP12 TRAF2 TRAF2 ENSCPOP00000025873 ENSCPOP00000025873 CHMP4B CHMP4B ENSCPOP00000025638 ENSCPOP00000025638 LOC100728277 LOC100728277 ENSCPOP00000024727 ENSCPOP00000024727 LOC100733054 LOC100733054 Hmgb1 Hmgb1 FLOT1 FLOT1 CHMP2B CHMP2B BIRC3 BIRC3 TNFSF10 TNFSF10 Faslg Faslg ENSCPOP00000031632 ENSCPOP00000031632 LOC100731649 LOC100731649 BAX BAX Ubc Ubc ENSCPOP00000032088 ENSCPOP00000032088 LOC100734223 LOC100734223 CHMP4C CHMP4C CDC37 CDC37 FAS FAS Ube2l3 Ube2l3 LOC100728774 LOC100728774 LOC100726326 LOC100726326 RIPK1 RIPK1 LOC100719669 LOC100719669 LOC100725217 LOC100725217 H0WDT2_CAVPO H0WDT2_CAVPO LOC100726034 LOC100726034 H0WAS6_CAVPO H0WAS6_CAVPO H0WAD6_CAVPO H0WAD6_CAVPO BIRC7 BIRC7 LOC100724690 LOC100724690 STUB1 STUB1 RIPK3 RIPK3 IL1A IL1A XIAP XIAP CASP10 CASP10 GSDME GSDME FLOT2 FLOT2 OGT OGT H0VPJ9_CAVPO H0VPJ9_CAVPO NPVF NPVF SDCBP SDCBP IRF2 IRF2 Casp3 Casp3 H0VK31_CAVPO H0VK31_CAVPO FADD FADD TRADD TRADD BIRC2 BIRC2 H0VET0_CAVPO H0VET0_CAVPO CHMP6 CHMP6 MLKL MLKL LOC100731744 LOC100731744 PRKN PRKN Rps27a Rps27a Pdcd6ip Pdcd6ip IL18 IL18 H0UZ83_CAVPO H0UZ83_CAVPO CHMP7 CHMP7 IL1B IL1B Chmp3 Chmp3 UBA52 UBA52 BAK1 BAK1 CFLAR CFLAR GSDMD GSDMD CASP8 CASP8 LOC100735067 LOC100735067 PELI1 PELI1 UBB UBB LOC100724240 LOC100724240 ENSCPOP00000028455 ENSCPOP00000028455 IRF1 IRF1 ENSCPOP00000027951 ENSCPOP00000027951 LOC100715008 LOC100715008 TTC6 TTC6 CHMP2A CHMP2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP12Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (400 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
ENSCPOP00000025873Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (92 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
ENSCPOP00000025638Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC100728277Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
ENSCPOP00000024727Peptidase S1 domain-containing protein. (242 aa)
LOC100733054Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
Hmgb1annotation not available (215 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
BIRC3Baculoviral IAP repeat containing 3. (600 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (293 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
LOC100731649Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
UbcUncharacterized protein. (159 aa)
ENSCPOP00000032088Uncharacterized protein. (191 aa)
LOC100734223Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (264 aa)
CHMP4CCharged multivesicular body protein 4C. (229 aa)
CDC37Cell division cycle 37. (378 aa)
FASFas cell surface death receptor. (334 aa)
Ube2l3UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
LOC100728774Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (229 aa)
LOC100726326Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (280 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (664 aa)
LOC100719669Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (299 aa)
LOC100725217Uncharacterized protein; Belongs to the peptidase C14A family. (361 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
LOC100726034Uncharacterized protein. (164 aa)
H0WAS6_CAVPOUncharacterized protein. (214 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
BIRC7Baculoviral IAP repeat containing 7. (272 aa)
LOC100724690Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (280 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (482 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (272 aa)
XIAPX-linked inhibitor of apoptosis. (496 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (474 aa)
GSDMEGasdermin E. (498 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
H0VPJ9_CAVPOPeptidase S1 domain-containing protein. (258 aa)
NPVFNeuropeptide VF precursor. (190 aa)
SDCBPSyndecan binding protein. (294 aa)
IRF2Interferon regulatory factor. (349 aa)
Casp3CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (165 aa)
H0VK31_CAVPOUncharacterized protein; Belongs to the peptidase C14A family. (365 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (206 aa)
TRADDTNFRSF1A associated via death domain. (310 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
H0VET0_CAVPOUncharacterized protein; Belongs to the peptidase C14A family. (204 aa)
CHMP6Charged multivesicular body protein 6. (201 aa)
MLKLMixed lineage kinase domain like pseudokinase. (449 aa)
LOC100731744NACHT domain-containing protein. (1402 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (443 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
Pdcd6ipBRO1 domain-containing protein. (872 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (189 aa)
H0UZ83_CAVPOPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
CHMP7Charged multivesicular body protein 7. (446 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
Chmp3Uncharacterized protein. (221 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
BAK1BCL2 antagonist/killer 1. (214 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (442 aa)
GSDMDGasdermin D. (481 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (481 aa)
LOC100735067Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
LOC100724240Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSCPOP00000028455Peptidase S1 domain-containing protein. (266 aa)
IRF1Interferon regulatory factor. (326 aa)
ENSCPOP00000027951Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (92 aa)
LOC100715008Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (218 aa)
TTC6Tetratricopeptide repeat domain 6. (592 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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