STRINGSTRING
LOC100731744 LOC100731744 OPTN OPTN RACK1 RACK1 CYLD CYLD USP4 USP4 MAP3K7 MAP3K7 SPATA2 SPATA2 BIRC3 BIRC3 RIPK1 RIPK1 H0WDT2_CAVPO H0WDT2_CAVPO TAB1 TAB1 IKBKG IKBKG RBCK1 RBCK1 TRAF1 TRAF1 UBB UBB ENSCPOP00000031632 ENSCPOP00000031632 Ubc Ubc CHUK CHUK TNFRSF1A TNFRSF1A USP2 USP2 TRAF2 TRAF2 H0WAD6_CAVPO H0WAD6_CAVPO BIRC7 BIRC7 XIAP XIAP Rnf31 Rnf31 USP21 USP21 TAB2 TAB2 SHARPIN SHARPIN TRADD TRADD TNFAIP3 TNFAIP3 IKBKB IKBKB BIRC2 BIRC2 UBA52 UBA52 OTUD7B OTUD7B TNF TNF TAB3 TAB3 Rps27a Rps27a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100731744NACHT domain-containing protein. (1402 aa)
OPTNOptineurin. (576 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (965 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
SPATA2Spermatogenesis associated 2. (513 aa)
BIRC3Baculoviral IAP repeat containing 3. (600 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (664 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (507 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (513 aa)
TRAF1TNF receptor-associated factor. (416 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
UbcUncharacterized protein. (159 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
TNFRSF1ATNF receptor superfamily member 1A. (469 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (611 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
BIRC7Baculoviral IAP repeat containing 7. (272 aa)
XIAPX-linked inhibitor of apoptosis. (496 aa)
Rnf31Uncharacterized protein. (1072 aa)
USP21Ubiquitin specific peptidase 21; Belongs to the peptidase C19 family. (570 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (665 aa)
SHARPINSHANK associated RH domain interactor. (383 aa)
TRADDTNFRSF1A associated via death domain. (310 aa)
TNFAIP3TNF alpha induced protein 3. (789 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
OTUD7BOTU deubiquitinase 7B. (842 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (679 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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