STRINGSTRING
MLH1 MLH1 MSH6 MSH6 MEIOB MEIOB RPA1 RPA1 EXO1 EXO1 PMS2 PMS2 RPA3 RPA3 PMS1 PMS1 Pold4 Pold4 POLD1 POLD1 POLD2 POLD2 H0VSI3_CAVPO H0VSI3_CAVPO MSH2 MSH2 PCNA PCNA RPA2 RPA2 Pold3 Pold3 Lig1 Lig1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MLH1MutL homolog 1. (758 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1336 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
EXO1Exonuclease 1. (839 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (890 aa)
RPA3Replication protein A3. (121 aa)
PMS1PMS1 homolog 1, mismatch repair system component. (930 aa)
Pold4Uncharacterized protein. (107 aa)
POLD1DNA polymerase. (1134 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
H0VSI3_CAVPODNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RPA2Replication protein A2. (270 aa)
Pold3Uncharacterized protein. (466 aa)
Lig1DNA ligase. (909 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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