STRINGSTRING
PSMA6 PSMA6 UBA52 UBA52 MKS1 MKS1 PSMB8 PSMB8 PSMB1 PSMB1 PRKAR2A PRKAR2A PSMB6 PSMB6 INTU INTU PSMB9 PSMB9 PRKAR2B PRKAR2B PTCH1 PTCH1 ADCY1 ADCY1 THAP7 THAP7 IFT140 IFT140 PSMD13 PSMD13 ADCY10 ADCY10 PSMC4 PSMC4 PRKAR1A PRKAR1A WDR19 WDR19 TUBA4A TUBA4A TULP3 TULP3 IFT122 IFT122 FUZ FUZ SKP1 SKP1 GLI1 GLI1 BTRC BTRC GLIS3 GLIS3 PTRHD1 PTRHD1 ADCY3 ADCY3 Rps27a Rps27a Pdcd2l Pdcd2l PSMD6 PSMD6 WDR35 WDR35 ADCY8 ADCY8 PSMB7 PSMB7 IFT57 IFT57 TEX52 TEX52 IFT88 IFT88 PSMC6 PSMC6 GLIS1 GLIS1 PSMD11 PSMD11 ADCY2 ADCY2 PSMD8 PSMD8 PSMD7 PSMD7 KIF3A KIF3A PSMC5 PSMC5 PSME4 PSME4 TUBB4B TUBB4B PSMA8 PSMA8 TUBB2B TUBB2B RPGRIP1L RPGRIP1L PRKAR1B PRKAR1B TUBA1B TUBA1B SMO SMO PSMA5 PSMA5 PSMF1 PSMF1 ITCH ITCH ADCY5 ADCY5 PSMB5 PSMB5 TTC21A TTC21A PSMA7 PSMA7 GSK3B GSK3B ADCY4 ADCY4 Psmd10 Psmd10 PSMD3 PSMD3 PSMB4 PSMB4 PSMA1 PSMA1 OFD1 OFD1 KIF7 KIF7 H0VV76_CAVPO H0VV76_CAVPO PSMC2 PSMC2 H0VWS1_CAVPO H0VWS1_CAVPO LOC100731885 LOC100731885 LOC100732987 LOC100732987 CUL1 CUL1 LOC100716197 LOC100716197 IFT52 IFT52 Psmd9 Psmd9 PSMA4 PSMA4 TULP1 TULP1 PSMB3 PSMB3 PSMB11 PSMB11 PSMD5 PSMD5 H0WAD6_CAVPO H0WAD6_CAVPO PSMB10 PSMB10 NUMBL NUMBL H0WDT2_CAVPO H0WDT2_CAVPO PSMD1 PSMD1 CSNK1A1 CSNK1A1 TTC21B TTC21B PSMA3 PSMA3 ENSCPOP00000023065 ENSCPOP00000023065 PSME1 PSME1 CNBD2 CNBD2 GLI2 GLI2 PSMC3 PSMC3 IFT172 IFT172 TUBB4A TUBB4A PSMD2 PSMD2 RBX1 RBX1 GLI3 GLI3 ADCY9 ADCY9 PRKACB PRKACB NUMB NUMB TUB TUB ADCY6 ADCY6 ADCY7 ADCY7 DYNC2H1 DYNC2H1 PSMD14 PSMD14 PSMD4 PSMD4 SUFU SUFU GPR161 GPR161 PSMD12 PSMD12 ENSCPOP00000029251 ENSCPOP00000029251 PSMB2 PSMB2 LOC100729187 LOC100729187 UBB UBB FOPNL FOPNL TUBB1 TUBB1 PSMC1 PSMC1 ENSCPOP00000031632 ENSCPOP00000031632 PSME2 PSME2 Ubc Ubc Psma2 Psma2 PSME3 PSME3 TUBB6 TUBB6 Prkaca Prkaca
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMA6Proteasome subunit alpha type. (246 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
MKS1MKS transition zone complex subunit 1. (558 aa)
PSMB8Proteasome subunit beta. (273 aa)
PSMB1Proteasome subunit beta. (241 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (395 aa)
PSMB6Proteasome subunit beta. (239 aa)
INTUInturned planar cell polarity protein. (938 aa)
PSMB9Proteasome subunit beta. (219 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (350 aa)
PTCH1Patched 1. (1379 aa)
ADCY1Adenylate cyclase 1. (944 aa)
THAP7THAP domain containing 7. (309 aa)
IFT140Intraflagellar transport 140. (1463 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (315 aa)
ADCY10Adenylate cyclase 10. (1581 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
WDR19WD repeat domain 19. (1341 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (449 aa)
IFT122Intraflagellar transport 122. (1218 aa)
FUZFuzzy planar cell polarity protein. (392 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (162 aa)
GLI1GLI family zinc finger 1. (1104 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (582 aa)
GLIS3GLIS family zinc finger 3. (932 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
Pdcd2lPDCD2_C domain-containing protein. (366 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
WDR35WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. (1157 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PSMB7Proteasome subunit beta. (277 aa)
IFT57Intraflagellar transport 57. (429 aa)
TEX52Testis expressed 52. (301 aa)
IFT88Intraflagellar transport 88. (825 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
GLIS1GLIS family zinc finger 1. (788 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (728 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSME4Proteasome activator subunit 4. (1827 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
TUBB2BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
RPGRIP1LRPGRIP1 like. (1260 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
PSMB5Proteasome subunit beta. (263 aa)
TTC21ATetratricopeptide repeat domain 21A. (1305 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
Psmd10ANK_REP_REGION domain-containing protein. (232 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
PSMA1Proteasome subunit alpha type. (270 aa)
OFD1OFD1 centriole and centriolar satellite protein. (996 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1336 aa)
H0VV76_CAVPOProtein kinase domain-containing protein. (196 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
H0VWS1_CAVPOANK_REP_REGION domain-containing protein. (213 aa)
LOC100731885Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
LOC100732987Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
LOC100716197Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
IFT52Intraflagellar transport 52. (406 aa)
Psmd9PDZ domain-containing protein. (223 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
TULP1TUB like protein 1; Belongs to the TUB family. (502 aa)
PSMB3Proteasome subunit beta. (207 aa)
PSMB11Proteasome subunit beta. (297 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
PSMB10Proteasome subunit beta. (273 aa)
NUMBLNUMB like endocytic adaptor protein. (603 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
CSNK1A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
TTC21BTetratricopeptide repeat domain 21B. (1316 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
ENSCPOP00000023065ANK_REP_REGION domain-containing protein. (179 aa)
PSME1Proteasome activator subunit 1. (249 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (587 aa)
GLI2GLI family zinc finger 2. (1570 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
IFT172Intraflagellar transport 172. (1749 aa)
TUBB4ATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (456 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
RBX1Ring-box 1. (108 aa)
GLI3GLI family zinc finger 3. (1580 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
NUMBNUMB endocytic adaptor protein. (648 aa)
TUBTubby-like protein; Belongs to the TUB family. (506 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4253 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (548 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
ENSCPOP00000029251Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
PSMB2Proteasome subunit beta. (201 aa)
LOC100729187Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
FOPNLFGFR1OP N-terminal like. (174 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (453 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
PSME2Proteasome activator subunit 2. (239 aa)
UbcUncharacterized protein. (159 aa)
Psma2Proteasome subunit alpha type. (234 aa)
PSME3Proteasome activator subunit 3. (254 aa)
TUBB6Tubulin beta 6 class V; Belongs to the tubulin family. (318 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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