STRINGSTRING
PSMB2 PSMB2 PSMA6 PSMA6 UBB UBB ENSCPOP00000030527 ENSCPOP00000030527 IHH IHH SHH SHH DHH DHH PTCH1 PTCH1 PSMD13 PSMD13 Ulk3 Ulk3 PSMC4 PSMC4 CDC73 CDC73 GLI1 GLI1 PSMA5 PSMA5 CDON CDON GLIS3 GLIS3 CUL3 CUL3 Rps27a Rps27a PSMD6 PSMD6 SPOPL SPOPL DZIP1L DZIP1L PSMB7 PSMB7 TEX52 TEX52 PSMC6 PSMC6 GLIS1 GLIS1 EVC2 EVC2 EVC EVC PSMD11 PSMD11 GAS8 GAS8 PSMD8 PSMD8 PSMD7 PSMD7 KIF3A KIF3A PSMC5 PSMC5 PSME4 PSME4 PSMA8 PSMA8 Iqce Iqce SMO SMO ARRB2 ARRB2 GRK2 GRK2 PSME3 PSME3 Psma2 Psma2 HHIP HHIP Ubc Ubc PSME2 PSME2 ENSCPOP00000031632 ENSCPOP00000031632 PSMC1 PSMC1 PSMF1 PSMF1 ITCH ITCH PSMB5 PSMB5 PSMA7 PSMA7 Psmd10 Psmd10 PSMD3 PSMD3 PSMB4 PSMB4 PSMA1 PSMA1 KIF7 KIF7 EFCAB7 EFCAB7 H0VV76_CAVPO H0VV76_CAVPO PSMC2 PSMC2 H0VWS1_CAVPO H0VWS1_CAVPO BOC BOC Psmd9 Psmd9 PSMA4 PSMA4 PSMB3 PSMB3 PSMB11 PSMB11 PSMD5 PSMD5 H0WAD6_CAVPO H0WAD6_CAVPO PSMB10 PSMB10 NUMBL NUMBL H0WDT2_CAVPO H0WDT2_CAVPO PSMD1 PSMD1 CSNK1A1 CSNK1A1 PSMA3 PSMA3 ENSCPOP00000023065 ENSCPOP00000023065 PSME1 PSME1 GLI2 GLI2 PSMC3 PSMC3 SMURF2 SMURF2 ARRB1 ARRB1 PSMD2 PSMD2 RBX1 RBX1 GLI3 GLI3 NUMB NUMB PSMD14 PSMD14 PSMD4 PSMD4 SUFU SUFU SPOP SPOP GPR161 GPR161 PSMB9 PSMB9 PSMB6 PSMB6 PSMB1 PSMB1 PSMB8 PSMB8 UBA52 UBA52 SMURF1 SMURF1 DZIP1 DZIP1 PSMD12 PSMD12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMB2Proteasome subunit beta. (201 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
ENSCPOP00000030527Uncharacterized protein. (111 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
PTCH1Patched 1. (1379 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (315 aa)
Ulk3Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (474 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
CDC73Cell division cycle 73. (430 aa)
GLI1GLI family zinc finger 1. (1104 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
CDONCell adhesion associated, oncogene regulated. (1265 aa)
GLIS3GLIS family zinc finger 3. (932 aa)
CUL3Cullin 3; Belongs to the cullin family. (765 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
SPOPLSpeckle type BTB/POZ protein like. (392 aa)
DZIP1LDAZ interacting zinc finger protein 1 like. (801 aa)
PSMB7Proteasome subunit beta. (277 aa)
TEX52Testis expressed 52. (301 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
GLIS1GLIS family zinc finger 1. (788 aa)
EVC2EvC ciliary complex subunit 2. (1198 aa)
EVCEvC ciliary complex subunit 1. (985 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
GAS8Growth arrest specific 8. (477 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (728 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSME4Proteasome activator subunit 4. (1827 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
IqceUncharacterized protein. (667 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
ARRB2Arrestin beta 2. (417 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (750 aa)
PSME3Proteasome activator subunit 3. (254 aa)
Psma2Proteasome subunit alpha type. (234 aa)
HHIPHedgehog interacting protein. (699 aa)
UbcUncharacterized protein. (159 aa)
PSME2Proteasome activator subunit 2. (239 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
Psmd10ANK_REP_REGION domain-containing protein. (232 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
PSMA1Proteasome subunit alpha type. (270 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1336 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
H0VV76_CAVPOProtein kinase domain-containing protein. (196 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
H0VWS1_CAVPOANK_REP_REGION domain-containing protein. (213 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1106 aa)
Psmd9PDZ domain-containing protein. (223 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
PSMB3Proteasome subunit beta. (207 aa)
PSMB11Proteasome subunit beta. (297 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
PSMB10Proteasome subunit beta. (273 aa)
NUMBLNUMB like endocytic adaptor protein. (603 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
CSNK1A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
ENSCPOP00000023065ANK_REP_REGION domain-containing protein. (179 aa)
PSME1Proteasome activator subunit 1. (249 aa)
GLI2GLI family zinc finger 2. (1570 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
SMURF2E3 ubiquitin-protein ligase. (782 aa)
ARRB1Arrestin beta 1. (430 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
RBX1Ring-box 1. (108 aa)
GLI3GLI family zinc finger 3. (1580 aa)
NUMBNUMB endocytic adaptor protein. (648 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (548 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB8Proteasome subunit beta. (273 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
DZIP1DAZ interacting zinc finger protein 1. (818 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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