STRINGSTRING
FGF17 FGF17 MKNK2 MKNK2 FGF8 FGF8 H0W160_CAVPO H0W160_CAVPO H0WAD6_CAVPO H0WAD6_CAVPO H0WDT2_CAVPO H0WDT2_CAVPO MAPK3 MAPK3 MAPK1 MAPK1 FNDC3B FNDC3B FGF20 FGF20 LOC100734047 LOC100734047 FGF19 FGF19 FGF16 FGF16 FGF18 FGF18 Rps27a Rps27a FGF23 FGF23 FGF2 FGF2 PTPN11 PTPN11 PPP2CB PPP2CB KLB KLB FRS2 FRS2 UBA52 UBA52 FNDC3A FNDC3A PPP2CA PPP2CA FGF1 FGF1 FGF6 FGF6 Mknk1 Mknk1 CBL CBL UBB UBB Fgf9 Fgf9 SPRY2 SPRY2 ENSCPOP00000031632 ENSCPOP00000031632 GRB2 GRB2 BRAF BRAF FGFR4 FGFR4 Ubc Ubc FGF4 FGF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
H0W160_CAVPOUncharacterized protein. (589 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
FNDC3BFibronectin type III domain containing 3B. (1101 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa)
LOC100734047Uncharacterized protein. (567 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (257 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (588 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
KLBKlotho beta. (1024 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
FNDC3AFibronectin type III domain containing 3A. (1172 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Mknk1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (421 aa)
CBLCbl proto-oncogene. (894 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (91 aa)
SPRY2Sprouty RTK signaling antagonist 2. (316 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (738 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
UbcUncharacterized protein. (159 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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