STRINGSTRING
UBA52 UBA52 SOS1 SOS1 FRS2 FRS2 FNDC3A FNDC3A KLB KLB PPP2CB PPP2CB FGF2 FGF2 FGF23 FGF23 Rps27a Rps27a FGF18 FGF18 PIK3CA PIK3CA PIK3R1 PIK3R1 FGF16 FGF16 FGF19 FGF19 LOC100734047 LOC100734047 FRS3 FRS3 FGF20 FGF20 NRAS NRAS KRAS KRAS FNDC3B FNDC3B GAB1 GAB1 MAPK1 MAPK1 PTPN11 PTPN11 FGF4 FGF4 FGF17 FGF17 MKNK2 MKNK2 FGF8 FGF8 PLCG1 PLCG1 H0W160_CAVPO H0W160_CAVPO SHC1 SHC1 H0WAD6_CAVPO H0WAD6_CAVPO H0WDT2_CAVPO H0WDT2_CAVPO MAPK3 MAPK3 PPP2CA PPP2CA FGF1 FGF1 FGF6 FGF6 Mknk1 Mknk1 CBL CBL UBB UBB Fgf9 Fgf9 SPRY2 SPRY2 ENSCPOP00000031632 ENSCPOP00000031632 GRB2 GRB2 BRAF BRAF FGFR4 FGFR4 CSDE1 CSDE1 Ubc Ubc HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FNDC3AFibronectin type III domain containing 3A. (1172 aa)
KLBKlotho beta. (1024 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (257 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
LOC100734047Uncharacterized protein. (567 aa)
FRS3Fibroblast growth factor receptor substrate 3. (485 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FNDC3BFibronectin type III domain containing 3B. (1101 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (588 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
H0W160_CAVPOUncharacterized protein. (589 aa)
SHC1SHC adaptor protein 1. (583 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Mknk1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (421 aa)
CBLCbl proto-oncogene. (894 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (91 aa)
SPRY2Sprouty RTK signaling antagonist 2. (316 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (738 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
UbcUncharacterized protein. (159 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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