STRINGSTRING
PSMA8 PSMA8 TNFRSF13C TNFRSF13C TNFRSF25 TNFRSF25 TNFRSF12A TNFRSF12A PSME3 PSME3 Psma2 Psma2 CHUK CHUK TNFRSF4 TNFRSF4 Ubc Ubc PSME2 PSME2 TNFSF11 TNFSF11 ENSCPOP00000031632 ENSCPOP00000031632 PSMC1 PSMC1 CD27 CD27 TNFSF13 TNFSF13 TNFSF13B TNFSF13B TNFSF14 TNFSF14 FBXW11 FBXW11 CD40LG CD40LG TRAF3 TRAF3 EDA EDA ENSCPOP00000030017 ENSCPOP00000030017 UBB UBB LTBR LTBR TNFSF4 TNFSF4 PSMA6 PSMA6 UBE2M UBE2M PSMB2 PSMB2 ENSCPOP00000029251 ENSCPOP00000029251 UBA3 UBA3 PSMD12 PSMD12 TNFRSF1A TNFRSF1A MAP3K14 MAP3K14 LTA LTA PSMD4 PSMD4 PSMD14 PSMD14 TNFSF18 TNFSF18 TRAF2 TRAF2 LTB LTB PSMD2 PSMD2 CD40 CD40 TNFSF8 TNFSF8 PSMC3 PSMC3 RELB RELB PSME1 PSME1 ENSCPOP00000023065 ENSCPOP00000023065 BIRC3 BIRC3 PSMA3 PSMA3 TRAF5 TRAF5 TNFSF15 TNFSF15 PSMD1 PSMD1 H0WDT2_CAVPO H0WDT2_CAVPO PSMB10 PSMB10 TNFSF12 TNFSF12 Cd70 Cd70 H0WAD6_CAVPO H0WAD6_CAVPO PSMD5 PSMD5 PSMB11 PSMB11 PSMB3 PSMB3 BIRC7 BIRC7 EDARADD EDARADD TNFRSF1B TNFRSF1B PSMA4 PSMA4 Psmd9 Psmd9 TNFRSF17 TNFRSF17 XIAP XIAP CUL1 CUL1 H0VWS1_CAVPO H0VWS1_CAVPO PSMC2 PSMC2 TNFRSF11A TNFRSF11A PSMA1 PSMA1 PSMB4 PSMB4 PSMD3 PSMD3 Psmd10 Psmd10 PSMA7 PSMA7 PSMB5 PSMB5 PSMF1 PSMF1 PSMA5 PSMA5 Eda2r Eda2r PSME4 PSME4 EDAR EDAR PSMC5 PSMC5 TNFRSF11B TNFRSF11B PSMD7 PSMD7 PSMD8 PSMD8 BIRC2 BIRC2 PSMD11 PSMD11 PSMC6 PSMC6 Tnfrsf14 Tnfrsf14 H0VE24_CAVPO H0VE24_CAVPO PSMB7 PSMB7 TNFRSF9 TNFRSF9 TNFRSF13B TNFRSF13B LOC100731744 LOC100731744 PSMD6 PSMD6 Rps27a Rps27a BTRC BTRC SKP1 SKP1 NFKB2 NFKB2 PSMC4 PSMC4 PSMD13 PSMD13 TNF TNF PSMB9 PSMB9 PSMB6 PSMB6 PSMB1 PSMB1 PSMB8 PSMB8 UBA52 UBA52
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMA8Proteasome subunit alpha type. (250 aa)
TNFRSF13CTNF receptor superfamily member 13C. (186 aa)
TNFRSF25TNF receptor superfamily member 25. (408 aa)
TNFRSF12ATNF receptor superfamily member 12A. (129 aa)
PSME3Proteasome activator subunit 3. (254 aa)
Psma2Proteasome subunit alpha type. (234 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
TNFRSF4TNF receptor superfamily member 4. (250 aa)
UbcUncharacterized protein. (159 aa)
PSME2Proteasome activator subunit 2. (239 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (315 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
CD27CD27 molecule. (233 aa)
TNFSF13TNF superfamily member 13; Belongs to the tumor necrosis factor family. (249 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (272 aa)
TNFSF14TNF superfamily member 14; Belongs to the tumor necrosis factor family. (241 aa)
FBXW11F-box and WD repeat domain containing 11. (530 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (390 aa)
ENSCPOP00000030017Uncharacterized protein. (226 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
LTBRLymphotoxin beta receptor. (417 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (185 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
PSMB2Proteasome subunit beta. (201 aa)
ENSCPOP00000029251Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
UBA3Ubiquitin like modifier activating enzyme 3. (380 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
TNFRSF1ATNF receptor superfamily member 1A. (469 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (937 aa)
LTATumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. (197 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
TNFSF18Tumor necrosis factor ligand 2A. (199 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
LTBLymphotoxin beta; Belongs to the tumor necrosis factor family. (241 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
CD40CD40 molecule. (285 aa)
TNFSF8Tumor necrosis factor ligand 3A; Belongs to the tumor necrosis factor family. (234 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
RELBRELB proto-oncogene, NF-kB subunit. (554 aa)
PSME1Proteasome activator subunit 1. (249 aa)
ENSCPOP00000023065ANK_REP_REGION domain-containing protein. (179 aa)
BIRC3Baculoviral IAP repeat containing 3. (600 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (565 aa)
TNFSF15Tumor necrosis factor ligand 1B. (275 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
PSMB10Proteasome subunit beta. (273 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (231 aa)
Cd70TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (221 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
PSMB11Proteasome subunit beta. (297 aa)
PSMB3Proteasome subunit beta. (207 aa)
BIRC7Baculoviral IAP repeat containing 7. (272 aa)
EDARADDEDAR associated death domain. (219 aa)
TNFRSF1BTNF receptor superfamily member 1B. (482 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
Psmd9PDZ domain-containing protein. (223 aa)
TNFRSF17TNF receptor superfamily member 17. (190 aa)
XIAPX-linked inhibitor of apoptosis. (496 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
H0VWS1_CAVPOANK_REP_REGION domain-containing protein. (213 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
TNFRSF11ATNF receptor superfamily member 11a. (515 aa)
PSMA1Proteasome subunit alpha type. (270 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
Psmd10ANK_REP_REGION domain-containing protein. (232 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
Eda2rUncharacterized protein. (252 aa)
PSME4Proteasome activator subunit 4. (1827 aa)
EDAREctodysplasin A receptor. (446 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (400 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
Tnfrsf14HVEM. (286 aa)
H0VE24_CAVPOTNFR-Cys domain-containing protein. (457 aa)
PSMB7Proteasome subunit beta. (277 aa)
TNFRSF9TNF receptor superfamily member 9. (241 aa)
TNFRSF13BTNF receptor superfamily member 13B. (247 aa)
LOC100731744NACHT domain-containing protein. (1402 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (582 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (162 aa)
NFKB2Nuclear factor kappa B subunit 2. (854 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (315 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB8Proteasome subunit beta. (273 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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