STRINGSTRING
CFLAR CFLAR Pdcd6ip Pdcd6ip Rps27a Rps27a PRKN PRKN LOC100731744 LOC100731744 MLKL MLKL BIRC2 BIRC2 TRADD TRADD FADD FADD SDCBP SDCBP XIAP XIAP CASP10 CASP10 FLOT2 FLOT2 OGT OGT CASP8 CASP8 FAS FAS Ube2l3 Ube2l3 TNFSF10 TNFSF10 Faslg Faslg ENSCPOP00000031632 ENSCPOP00000031632 Ubc Ubc CDC37 CDC37 H0WAD6_CAVPO H0WAD6_CAVPO BIRC7 BIRC7 STUB1 STUB1 RIPK3 RIPK3 H0WDT2_CAVPO H0WDT2_CAVPO RIPK1 RIPK1 BIRC3 BIRC3 FLOT1 FLOT1 TRAF2 TRAF2 TTC6 TTC6 UBB UBB PELI1 PELI1 UBA52 UBA52
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (442 aa)
Pdcd6ipBRO1 domain-containing protein. (872 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (443 aa)
LOC100731744NACHT domain-containing protein. (1402 aa)
MLKLMixed lineage kinase domain like pseudokinase. (449 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
TRADDTNFRSF1A associated via death domain. (310 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (206 aa)
SDCBPSyndecan binding protein. (294 aa)
XIAPX-linked inhibitor of apoptosis. (496 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (474 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (481 aa)
FASFas cell surface death receptor. (334 aa)
Ube2l3UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (293 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
UbcUncharacterized protein. (159 aa)
CDC37Cell division cycle 37. (378 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
BIRC7Baculoviral IAP repeat containing 7. (272 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (482 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (664 aa)
BIRC3Baculoviral IAP repeat containing 3. (600 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
TTC6Tetratricopeptide repeat domain 6. (592 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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