13 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Your Input:
	LIG3	DNA ligase. (1012 aa)
	RBBP8	RB binding protein 8, endonuclease. (900 aa)
	BRCA2	BRCA2 DNA repair associated. (3151 aa)
	Rad50	Zinc-hook domain-containing protein. (1275 aa)
	RAD52	RAD52 homolog, DNA repair protein. (280 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	XRCC1	X-ray repair cross complementing 1. (629 aa)
	ENSCPOP00000024428	PARP-type domain-containing protein. (104 aa)
	PARP2	Poly [ADP-ribose] polymerase. (536 aa)
	Parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa)
	PARP3	Poly [ADP-ribose] polymerase. (533 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA2	ENSCPOP00000024428	ENSCPOP00000004635	ENSCPOP00000024428	BRCA2 DNA repair associated.	PARP-type domain-containing protein.	0.800
BRCA2	FEN1	ENSCPOP00000004635	ENSCPOP00000032223	BRCA2 DNA repair associated.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.801
BRCA2	MRE11	ENSCPOP00000004635	ENSCPOP00000013122	BRCA2 DNA repair associated.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.844
BRCA2	NBN	ENSCPOP00000004635	ENSCPOP00000012336	BRCA2 DNA repair associated.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.834
BRCA2	PARP2	ENSCPOP00000004635	ENSCPOP00000018168	BRCA2 DNA repair associated.	Poly [ADP-ribose] polymerase.	0.783
BRCA2	PARP3	ENSCPOP00000004635	ENSCPOP00000012500	BRCA2 DNA repair associated.	Poly [ADP-ribose] polymerase.	0.713
BRCA2	Parp1	ENSCPOP00000004635	ENSCPOP00000014109	BRCA2 DNA repair associated.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.800
BRCA2	RAD52	ENSCPOP00000004635	ENSCPOP00000000644	BRCA2 DNA repair associated.	RAD52 homolog, DNA repair protein.	0.710
BRCA2	RBBP8	ENSCPOP00000004635	ENSCPOP00000006941	BRCA2 DNA repair associated.	RB binding protein 8, endonuclease.	0.866
BRCA2	Rad50	ENSCPOP00000004635	ENSCPOP00000002019	BRCA2 DNA repair associated.	Zinc-hook domain-containing protein.	0.733
BRCA2	XRCC1	ENSCPOP00000004635	ENSCPOP00000031519	BRCA2 DNA repair associated.	X-ray repair cross complementing 1.	0.747
ENSCPOP00000024428	BRCA2	ENSCPOP00000024428	ENSCPOP00000004635	PARP-type domain-containing protein.	BRCA2 DNA repair associated.	0.800
ENSCPOP00000024428	FEN1	ENSCPOP00000024428	ENSCPOP00000032223	PARP-type domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.790
ENSCPOP00000024428	LIG3	ENSCPOP00000024428	ENSCPOP00000011732	PARP-type domain-containing protein.	DNA ligase.	0.643
ENSCPOP00000024428	MRE11	ENSCPOP00000024428	ENSCPOP00000013122	PARP-type domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.687
ENSCPOP00000024428	NBN	ENSCPOP00000024428	ENSCPOP00000012336	PARP-type domain-containing protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.675
ENSCPOP00000024428	PARP2	ENSCPOP00000024428	ENSCPOP00000018168	PARP-type domain-containing protein.	Poly [ADP-ribose] polymerase.	0.879
ENSCPOP00000024428	PARP3	ENSCPOP00000024428	ENSCPOP00000012500	PARP-type domain-containing protein.	Poly [ADP-ribose] polymerase.	0.862
ENSCPOP00000024428	RAD52	ENSCPOP00000024428	ENSCPOP00000000644	PARP-type domain-containing protein.	RAD52 homolog, DNA repair protein.	0.588
ENSCPOP00000024428	RBBP8	ENSCPOP00000024428	ENSCPOP00000006941	PARP-type domain-containing protein.	RB binding protein 8, endonuclease.	0.704