STRINGSTRING
Chek1 Chek1 XRCC3 XRCC3 RFC5 RFC5 POLD2 POLD2 H0WAD6_CAVPO H0WAD6_CAVPO RFC3 RFC3 MUS81 MUS81 RPA1 RPA1 UBA52 UBA52 EXO1 EXO1 EME1 EME1 Slx1a Slx1a H0WDT2_CAVPO H0WDT2_CAVPO POLD1 POLD1 POLE4 POLE4 Pold4 Pold4 POLE3 POLE3 POLK POLK MEIOB MEIOB RPA2 RPA2 PCNA PCNA MAML1 MAML1 EXD2 EXD2 RMI1 RMI1 TDRD3 TDRD3 RAD51B RAD51B ATM ATM RFC4 RFC4 BARD1 BARD1 BRIP1 BRIP1 KAT5 KAT5 DNA2 DNA2 SLX4 SLX4 GEN1 GEN1 ANKRD12 ANKRD12 ENSCPOP00000025455 ENSCPOP00000025455 RPA3 RPA3 POLH POLH RCBTB2 RCBTB2 EME2 EME2 RCBTB1 RCBTB1 RMI2 RMI2 UBB UBB RAD51AP1 RAD51AP1 XRCC2 XRCC2 RFC2 RFC2 RBBP8 RBBP8 RAD51D RAD51D ENSCPOP00000031632 ENSCPOP00000031632 Ubc Ubc BLM BLM Rad50 Rad50 WRN WRN TOP3A TOP3A Brca1 Brca1 POLE POLE NBN NBN RAD51 RAD51 MRE11 MRE11 RECQL4 RECQL4 RFC1 RFC1 POLE2 POLE2 RAD51C RAD51C BRCA2 BRCA2 Rps27a Rps27a PALB2 PALB2 Pold3 Pold3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (338 aa)
RFC5Replication factor C subunit 5. (340 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
RFC3Replication factor C subunit 3. (220 aa)
MUS81MUS81 structure-specific endonuclease subunit. (562 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
EXO1Exonuclease 1. (839 aa)
EME1Essential meiotic structure-specific endonuclease 1. (578 aa)
Slx1aStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (266 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
POLD1DNA polymerase. (1134 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (116 aa)
Pold4Uncharacterized protein. (107 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
POLKDNA polymerase kappa. (540 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
RPA2Replication protein A2. (270 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MAML1Mastermind like transcriptional coactivator 1. (794 aa)
EXD2Exonuclease 3'-5' domain containing 2. (619 aa)
RMI1RecQ mediated genome instability 1. (617 aa)
TDRD3Tudor domain containing 3. (692 aa)
RAD51BRAD51 paralog B. (258 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa)
RFC4Replication factor C subunit 4. (363 aa)
BARD1BRCA1 associated RING domain 1. (662 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (971 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
DNA2DNA replication helicase/nuclease 2. (1021 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1738 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (916 aa)
ANKRD12Ankyrin repeat domain 12. (2046 aa)
ENSCPOP00000025455Protein kinase domain-containing protein. (360 aa)
RPA3Replication protein A3. (121 aa)
POLHDNA polymerase eta. (712 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (371 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RMI2RecQ mediated genome instability 2. (147 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
RAD51AP1RAD51 associated protein 1. (334 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
RFC2Replication factor C subunit 2. (352 aa)
RBBP8RB binding protein 8, endonuclease. (900 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (329 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
UbcUncharacterized protein. (159 aa)
BLMBLM RecQ like helicase. (1405 aa)
Rad50Zinc-hook domain-containing protein. (1275 aa)
WRNWRN RecQ like helicase. (1462 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1027 aa)
Brca1Uncharacterized protein. (79 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa)
RECQL4RecQ like helicase 4. (1226 aa)
RFC1Replication factor C subunit 1. (1153 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
RAD51CRAD51 paralog C. (373 aa)
BRCA2BRCA2 DNA repair associated. (3151 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
PALB2Partner and localizer of BRCA2. (1172 aa)
Pold3Uncharacterized protein. (466 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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