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| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa) |
| | ENSCPOP00000033122 | MPN domain-containing protein. (250 aa) |
| | LOC100731150 | annotation not available (103 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1027 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | Ubc | Uncharacterized protein. (159 aa) |
| | ENSCPOP00000031632 | Ubiquitin-like domain-containing protein. (141 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (329 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (629 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | LOC106027456 | annotation not available (126 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (334 aa) |
| | ENSCPOP00000030090 | annotation not available (126 aa) |
| | UBB | Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | PWWP2A | PWWP domain containing 2A. (722 aa) |
| | ENSCPOP00000029297 | annotation not available (103 aa) |
| | ENSCPOP00000029061 | annotation not available (126 aa) |
| | ENSCPOP00000028155 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (102 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (371 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (145 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1392 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (358 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | ENSCPOP00000027005 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (83 aa) |
| | ENSCPOP00000026646 | annotation not available (126 aa) |
| | ENSCPOP00000026400 | annotation not available (125 aa) |
| | PPP4R2 | Protein phosphatase 4 regulatory subunit 2. (416 aa) |
| | LOC100713990 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC100717396 | Uncharacterized protein. (1249 aa) |
| | ENSCPOP00000025455 | Protein kinase domain-containing protein. (360 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (233 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) |
| | LOC100728325 | annotation not available (103 aa) |
| | H2BC18 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ANKRD12 | Ankyrin repeat domain 12. (2046 aa) |
| | ENSCPOP00000024428 | PARP-type domain-containing protein. (104 aa) |
| | ENSCPOP00000024383 | annotation not available (126 aa) |
| | HIST2H2BE | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCPOP00000024347 | annotation not available (103 aa) |
| | ENSCPOP00000024311 | annotation not available (126 aa) |
| | LOC100733876 | annotation not available (103 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (291 aa) |
| | ENSCPOP00000023894 | annotation not available (126 aa) |
| | TIMELESS | Timeless circadian regulator. (1239 aa) |
| | LOC100717510 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (916 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | ENSCPOP00000023362 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1738 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1021 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | Pold4 | Uncharacterized protein. (107 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | LOC100735546 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (116 aa) |
| | POLD1 | DNA polymerase. (1134 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (420 aa) |
| | H0WDT2_CAVPO | Ubiquitin-like domain-containing protein. (127 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (282 aa) |
| | Slx1a | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (266 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (578 aa) |
| | H0WAD6_CAVPO | Ubiquitin-like domain-containing protein. (111 aa) |
| | LOC100735042 | Histone domain-containing protein; Belongs to the histone H2B family. (125 aa) |
| | LOC111756490 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (536 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | LOC100728920 | Histone domain-containing protein; Belongs to the histone H2B family. (128 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (401 aa) |
| | H0VYV4_CAVPO | Uncharacterized protein. (260 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (338 aa) |
| | Chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa) |
| | RNF169 | Ring finger protein 169. (699 aa) |
| | Parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa) |
| | RECQL4 | RecQ like helicase 4. (1226 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (533 aa) |
| | CCP110 | Centriolar coiled-coil protein 110. (1010 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (249 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | EXO1 | Exonuclease 1. (839 aa) |
| | ATRIP | ATR interacting protein. (792 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (280 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (696 aa) |
| | POLK | DNA polymerase kappa. (540 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (371 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | BLM | BLM RecQ like helicase. (1405 aa) |
| | H0UX17_CAVPO | BRCT domain-containing protein. (722 aa) |
| | SIRT7 | Sirtuin 7. (401 aa) |
| | Rad50 | Zinc-hook domain-containing protein. (1275 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (514 aa) |
| | WRN | WRN RecQ like helicase. (1462 aa) |
| | RFC1 | Replication factor C subunit 1. (1153 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | RAD51C | RAD51 paralog C. (373 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1061 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3151 aa) |
| | Rps27a | Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1172 aa) |
| | Babam1 | Uncharacterized protein. (337 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa) |
| | Pold3 | Uncharacterized protein. (466 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1366 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (900 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (562 aa) |
| | RFC3 | Replication factor C subunit 3. (220 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | MAML1 | Mastermind like transcriptional coactivator 1. (794 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (619 aa) |
| | RMI1 | RecQ mediated genome instability 1. (617 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (716 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (429 aa) |
| | TDRD3 | Tudor domain containing 3. (692 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4711 aa) |
| | RAD51B | RAD51 paralog B. (258 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (662 aa) |
| | Clspn | Uncharacterized protein. (1330 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (971 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | LIG3 | DNA ligase. (1012 aa) |
| | LOC106026468 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa) |
| | Brca1 | Uncharacterized protein. (79 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa) |
