STRINGSTRING
SLX4 SLX4 TOP3A TOP3A RAD51D RAD51D RAD51AP1 RAD51AP1 RMI2 RMI2 EME2 EME2 ANKRD12 ANKRD12 GEN1 GEN1 DNA2 DNA2 KAT5 KAT5 Slx1a Slx1a EME1 EME1 XRCC3 XRCC3 RECQL4 RECQL4 MRE11 MRE11 RAD51 RAD51 NBN NBN Brca1 Brca1 XRCC2 XRCC2 BRIP1 BRIP1 BARD1 BARD1 ATM ATM RAD51B RAD51B RMI1 RMI1 MAML1 MAML1 MUS81 MUS81 RBBP8 RBBP8 PALB2 PALB2 BRCA2 BRCA2 RAD51C RAD51C WRN WRN Rad50 Rad50 BLM BLM EXO1 EXO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLX4SLX4 structure-specific endonuclease subunit. (1738 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1027 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (329 aa)
RAD51AP1RAD51 associated protein 1. (334 aa)
RMI2RecQ mediated genome instability 2. (147 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (371 aa)
ANKRD12Ankyrin repeat domain 12. (2046 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (916 aa)
DNA2DNA replication helicase/nuclease 2. (1021 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
Slx1aStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (266 aa)
EME1Essential meiotic structure-specific endonuclease 1. (578 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (338 aa)
RECQL4RecQ like helicase 4. (1226 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa)
Brca1Uncharacterized protein. (79 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (971 aa)
BARD1BRCA1 associated RING domain 1. (662 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa)
RAD51BRAD51 paralog B. (258 aa)
RMI1RecQ mediated genome instability 1. (617 aa)
MAML1Mastermind like transcriptional coactivator 1. (794 aa)
MUS81MUS81 structure-specific endonuclease subunit. (562 aa)
RBBP8RB binding protein 8, endonuclease. (900 aa)
PALB2Partner and localizer of BRCA2. (1172 aa)
BRCA2BRCA2 DNA repair associated. (3151 aa)
RAD51CRAD51 paralog C. (373 aa)
WRNWRN RecQ like helicase. (1462 aa)
Rad50Zinc-hook domain-containing protein. (1275 aa)
BLMBLM RecQ like helicase. (1405 aa)
EXO1Exonuclease 1. (839 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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