STRINGSTRING
SUMO1 SUMO1 ENSCPOP00000024347 ENSCPOP00000024347 UBE2V2 UBE2V2 ENSCPOP00000024311 ENSCPOP00000024311 LOC100733876 LOC100733876 BRCC3 BRCC3 ENSCPOP00000023894 ENSCPOP00000023894 LOC100717510 LOC100717510 ENSCPOP00000023362 ENSCPOP00000023362 PPP5C PPP5C KDM4B KDM4B KAT5 KAT5 LOC100735546 LOC100735546 UBA52 UBA52 ABRAXAS1 ABRAXAS1 H0UX17_CAVPO H0UX17_CAVPO Rad50 Rad50 PIAS4 PIAS4 BAP1 BAP1 UBXN1 UBXN1 Rps27a Rps27a CHEK2 CHEK2 APBB2 APBB2 Babam1 Babam1 NSD2 NSD2 Kdm4a Kdm4a UIMC1 UIMC1 HERC2 HERC2 ATM ATM BARD1 BARD1 EYA3 EYA3 H2BC1 H2BC1 LOC106026468 LOC106026468 EYA2 EYA2 Brca1 Brca1 NBN NBN MRE11 MRE11 H0WAD6_CAVPO H0WAD6_CAVPO LOC100735042 LOC100735042 LOC111756490 LOC111756490 LOC100728920 LOC100728920 H0VYV4_CAVPO H0VYV4_CAVPO LOC100721657 LOC100721657 APBB1 APBB1 Kpna2 Kpna2 RNF169 RNF169 H0WDT2_CAVPO H0WDT2_CAVPO MAPK8 MAPK8 ENSCPOP00000024383 ENSCPOP00000024383 HIST2H2BE HIST2H2BE ENSCPOP00000033122 ENSCPOP00000033122 LOC100731150 LOC100731150 Ubc Ubc ENSCPOP00000031632 ENSCPOP00000031632 ANKRD12 ANKRD12 RNF8 RNF8 UBE2I UBE2I LOC106027456 LOC106027456 ENSCPOP00000030090 ENSCPOP00000030090 UBB UBB TP53 TP53 PWWP2A PWWP2A ENSCPOP00000029297 ENSCPOP00000029297 ENSCPOP00000029061 ENSCPOP00000029061 EYA1 EYA1 ENSCPOP00000028155 ENSCPOP00000028155 BABAM2 BABAM2 ENSCPOP00000027005 ENSCPOP00000027005 ENSCPOP00000026646 ENSCPOP00000026646 EYA4 EYA4 ENSCPOP00000026608 ENSCPOP00000026608 ENSCPOP00000026400 ENSCPOP00000026400 LOC100713990 LOC100713990 RNF168 RNF168 LOC100728325 LOC100728325 H2BC18 H2BC18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUMO1Small ubiquitin-related modifier. (101 aa)
ENSCPOP00000024347annotation not available (103 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (145 aa)
ENSCPOP00000024311annotation not available (126 aa)
LOC100733876annotation not available (103 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (291 aa)
ENSCPOP00000023894annotation not available (126 aa)
LOC100717510Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSCPOP00000023362UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
PPP5CSerine/threonine-protein phosphatase. (533 aa)
KDM4BLysine demethylase 4B. (1100 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
LOC100735546Histone H2B; Belongs to the histone H2B family. (126 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (371 aa)
H0UX17_CAVPOBRCT domain-containing protein. (722 aa)
Rad50Zinc-hook domain-containing protein. (1275 aa)
PIAS4Protein inhibitor of activated STAT 4. (514 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
UBXN1UBX domain protein 1. (293 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
CHEK2Checkpoint kinase 2. (546 aa)
APBB2Amyloid beta precursor protein binding family B member 2. (761 aa)
Babam1Uncharacterized protein. (337 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1366 aa)
Kdm4aUncharacterized protein. (978 aa)
UIMC1Ubiquitin interaction motif containing 1. (716 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4711 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa)
BARD1BRCA1 associated RING domain 1. (662 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (497 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC106026468UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (529 aa)
Brca1Uncharacterized protein. (79 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
LOC100735042Histone domain-containing protein; Belongs to the histone H2B family. (125 aa)
LOC111756490Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC100728920Histone domain-containing protein; Belongs to the histone H2B family. (128 aa)
H0VYV4_CAVPOUncharacterized protein. (260 aa)
LOC100721657Uncharacterized protein. (854 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (709 aa)
Kpna2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
RNF169Ring finger protein 169. (699 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSCPOP00000024383annotation not available (126 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
ENSCPOP00000033122MPN domain-containing protein. (250 aa)
LOC100731150annotation not available (103 aa)
UbcUncharacterized protein. (159 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
ANKRD12Ankyrin repeat domain 12. (2046 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
LOC106027456annotation not available (126 aa)
ENSCPOP00000030090annotation not available (126 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
PWWP2APWWP domain containing 2A. (722 aa)
ENSCPOP00000029297annotation not available (103 aa)
ENSCPOP00000029061annotation not available (126 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
ENSCPOP00000028155UBIQUITIN_CONJUGAT_2 domain-containing protein. (102 aa)
BABAM2BRISC and BRCA1 A complex member 2. (358 aa)
ENSCPOP00000027005UBIQUITIN_CONJUGAT_2 domain-containing protein. (83 aa)
ENSCPOP00000026646annotation not available (126 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
ENSCPOP00000026608Importin subunit alpha; Functions in nuclear protein import. (446 aa)
ENSCPOP00000026400annotation not available (125 aa)
LOC100713990Histone H2B; Belongs to the histone H2B family. (126 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
LOC100728325annotation not available (103 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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