STRINGSTRING
ERCC5 ERCC5 UBA52 UBA52 RPA1 RPA1 GTF2H3 GTF2H3 USP45 USP45 Cetn2 Cetn2 LOC106026468 LOC106026468 DDB2 DDB2 H0VPN0_CAVPO H0VPN0_CAVPO PARP3 PARP3 MNAT1 MNAT1 CDK7 CDK7 H0VSL9_CAVPO H0VSL9_CAVPO Parp1 Parp1 KCTD2 KCTD2 SUMO3 SUMO3 H0VXB5_CAVPO H0VXB5_CAVPO PARP2 PARP2 H0W9J0_CAVPO H0W9J0_CAVPO H0WAD6_CAVPO H0WAD6_CAVPO VWA5B2 VWA5B2 H0WDT2_CAVPO H0WDT2_CAVPO GTF2H4 GTF2H4 ENSCPOP00000022087 ENSCPOP00000022087 Bivm Bivm CCNH CCNH ENSCPOP00000023362 ENSCPOP00000023362 ENSCPOP00000024428 ENSCPOP00000024428 RAD23B RAD23B ENSCPOP00000024881 ENSCPOP00000024881 ERCC2 ERCC2 RBX1 RBX1 CUL4B CUL4B LOC100732574 LOC100732574 Sumo2 Sumo2 GTF2H1 GTF2H1 ENSCPOP00000027005 ENSCPOP00000027005 RPA3 RPA3 DDB1 DDB1 RAD23A RAD23A UBE2V2 UBE2V2 SUMO1 SUMO1 RNF111 RNF111 ENSCPOP00000028155 ENSCPOP00000028155 GTF2H5 GTF2H5 ENSCPOP00000029727 ENSCPOP00000029727 UBB UBB ENSCPOP00000029995 ENSCPOP00000029995 PIAS3 PIAS3 CETN3 CETN3 UBE2I UBE2I ERCC1 ERCC1 ENSCPOP00000031632 ENSCPOP00000031632 SUMO4 SUMO4 Ubc Ubc VTCN1 VTCN1 ENSCPOP00000032444 ENSCPOP00000032444 CHD1L CHD1L H0VDH6_CAVPO H0VDH6_CAVPO RPA2 RPA2 CUL4A CUL4A PIAS1 PIAS1 XPC XPC Rps27a Rps27a H0V698_CAVPO H0V698_CAVPO VWA5A VWA5A ERCC4 ERCC4 VWA5B1 VWA5B1 WDR76 WDR76 ERCC3 ERCC3 XPA XPA MEIOB MEIOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERCC5ERCC excision repair 5, endonuclease. (1059 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
GTF2H3General transcription factor IIH subunit 3. (309 aa)
USP45Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (591 aa)
Cetn2Uncharacterized protein. (172 aa)
LOC106026468UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
DDB2Damage specific DNA binding protein 2. (289 aa)
H0VPN0_CAVPOC1_4 domain-containing protein. (286 aa)
PARP3Poly [ADP-ribose] polymerase. (533 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
CDK7Cyclin dependent kinase 7. (335 aa)
H0VSL9_CAVPOSsl1 domain-containing protein. (160 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
KCTD2Potassium channel tetramerization domain containing 2. (264 aa)
SUMO3Small ubiquitin-related modifier. (109 aa)
H0VXB5_CAVPOUbiquitin-like domain-containing protein. (140 aa)
PARP2Poly [ADP-ribose] polymerase. (536 aa)
H0W9J0_CAVPOUncharacterized protein. (147 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1204 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (485 aa)
ENSCPOP00000022087Uncharacterized protein. (161 aa)
BivmUncharacterized protein. (503 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
ENSCPOP00000023362UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
ENSCPOP00000024881Rad60-SLD domain-containing protein. (74 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
RBX1Ring-box 1. (108 aa)
CUL4BCullin 4B; Belongs to the cullin family. (936 aa)
LOC100732574General transcription factor IIH subunit. (395 aa)
Sumo2Small ubiquitin-related modifier. (95 aa)
GTF2H1General transcription factor IIH subunit 1. (556 aa)
ENSCPOP00000027005UBIQUITIN_CONJUGAT_2 domain-containing protein. (83 aa)
RPA3Replication protein A3. (121 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (362 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (145 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
RNF111Ring finger protein 111. (994 aa)
ENSCPOP00000028155UBIQUITIN_CONJUGAT_2 domain-containing protein. (102 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
ENSCPOP00000029727C1_4 domain-containing protein. (309 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
ENSCPOP00000029995Ig-like domain-containing protein. (263 aa)
PIAS3Protein inhibitor of activated STAT 3. (628 aa)
CETN3Centrin 3. (163 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
SUMO4Small ubiquitin-related modifier. (81 aa)
UbcUncharacterized protein. (159 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (282 aa)
ENSCPOP00000032444annotation not available (74 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (897 aa)
H0VDH6_CAVPOVWFA domain-containing protein. (365 aa)
RPA2Replication protein A2. (270 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
PIAS1Protein inhibitor of activated STAT 1. (651 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (923 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
H0V698_CAVPOC2H2-type domain-containing protein. (374 aa)
VWA5AVon Willebrand factor A domain containing 5A. (798 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1203 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (623 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (781 aa)
XPAXPA, DNA damage recognition and repair factor. (263 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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