STRINGSTRING
ACTL6A ACTL6A ENSCPOP00000032444 ENSCPOP00000032444 VTCN1 VTCN1 Ubc Ubc SUMO4 SUMO4 ENSCPOP00000031632 ENSCPOP00000031632 COPS7B COPS7B ERCC1 ERCC1 UBE2I UBE2I CETN3 CETN3 PIAS3 PIAS3 ENSCPOP00000029995 ENSCPOP00000029995 UBB UBB ENSCPOP00000029727 ENSCPOP00000029727 GTF2H5 GTF2H5 ENSCPOP00000028155 ENSCPOP00000028155 RNF111 RNF111 RCBTB1 RCBTB1 SUMO1 SUMO1 WBP1 WBP1 RCBTB2 RCBTB2 UBE2V2 UBE2V2 RAD23A RAD23A DDB1 DDB1 RPA3 RPA3 INO80C INO80C ENSCPOP00000027005 ENSCPOP00000027005 GTF2H1 GTF2H1 Sumo2 Sumo2 LOC100732574 LOC100732574 CUL4B CUL4B RBX1 RBX1 ERCC2 ERCC2 ENSCPOP00000024881 ENSCPOP00000024881 RAD23B RAD23B ENSCPOP00000024428 ENSCPOP00000024428 ENSCPOP00000023362 ENSCPOP00000023362 CCNH CCNH Bivm Bivm COPS8 COPS8 POLE3 POLE3 Pold4 Pold4 ENSCPOP00000022087 ENSCPOP00000022087 POLE4 POLE4 POLD1 POLD1 GTF2H4 GTF2H4 H0WDT2_CAVPO H0WDT2_CAVPO VWA5B2 VWA5B2 H0WAD6_CAVPO H0WAD6_CAVPO H0W9J0_CAVPO H0W9J0_CAVPO POLD2 POLD2 PARP2 PARP2 COPS4 COPS4 Yy1 Yy1 RFC5 RFC5 COPS6 COPS6 H0VXB5_CAVPO H0VXB5_CAVPO SUMO3 SUMO3 KCTD2 KCTD2 Parp1 Parp1 H0VSL9_CAVPO H0VSL9_CAVPO CDK7 CDK7 MNAT1 MNAT1 PARP3 PARP3 H0VPN0_CAVPO H0VPN0_CAVPO POLE POLE DDB2 DDB2 LOC106026468 LOC106026468 Ino80b Ino80b RFC2 RFC2 Cetn2 Cetn2 INO80E INO80E ATAD5 ATAD5 COPS5 COPS5 ACTR5 ACTR5 TFPT TFPT INO80 INO80 RFC4 RFC4 MCRS1 MCRS1 H0VI45_CAVPO H0VI45_CAVPO USP45 USP45 GTF2H3 GTF2H3 RUVBL1 RUVBL1 PCNA PCNA CHD1L CHD1L H0VDH6_CAVPO H0VDH6_CAVPO RPA2 RPA2 RFC3 RFC3 CUL4A CUL4A PIAS1 PIAS1 ACTR8 ACTR8 Pold3 Pold3 XPC XPC Rps27a Rps27a H0V698_CAVPO H0V698_CAVPO COPS3 COPS3 VWA5A VWA5A ERCC4 ERCC4 POLE2 POLE2 RFC1 RFC1 COPS2 COPS2 VWA5B1 VWA5B1 RPAP3 RPAP3 WDR76 WDR76 ERCC3 ERCC3 GPS1 GPS1 XPA XPA MEIOB MEIOB ERCC5 ERCC5 POLK POLK NFRKB NFRKB UBA52 UBA52 COPS7A COPS7A RPA1 RPA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTL6AActin like 6A; Belongs to the actin family. (429 aa)
ENSCPOP00000032444annotation not available (74 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (282 aa)
UbcUncharacterized protein. (159 aa)
SUMO4Small ubiquitin-related modifier. (81 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
COPS7BCOP9 signalosome subunit 7B. (264 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
CETN3Centrin 3. (163 aa)
PIAS3Protein inhibitor of activated STAT 3. (628 aa)
ENSCPOP00000029995Ig-like domain-containing protein. (263 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
ENSCPOP00000029727C1_4 domain-containing protein. (309 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
ENSCPOP00000028155UBIQUITIN_CONJUGAT_2 domain-containing protein. (102 aa)
RNF111Ring finger protein 111. (994 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
WBP1WW domain binding protein 1. (303 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (145 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (362 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
RPA3Replication protein A3. (121 aa)
INO80CINO80 complex subunit C. (192 aa)
ENSCPOP00000027005UBIQUITIN_CONJUGAT_2 domain-containing protein. (83 aa)
GTF2H1General transcription factor IIH subunit 1. (556 aa)
Sumo2Small ubiquitin-related modifier. (95 aa)
LOC100732574General transcription factor IIH subunit. (395 aa)
CUL4BCullin 4B; Belongs to the cullin family. (936 aa)
RBX1Ring-box 1. (108 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
ENSCPOP00000024881Rad60-SLD domain-containing protein. (74 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
ENSCPOP00000023362UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
BivmUncharacterized protein. (503 aa)
COPS8COP9 signalosome subunit 8. (209 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
Pold4Uncharacterized protein. (107 aa)
ENSCPOP00000022087Uncharacterized protein. (161 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (116 aa)
POLD1DNA polymerase. (1134 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (485 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1204 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
H0W9J0_CAVPOUncharacterized protein. (147 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
PARP2Poly [ADP-ribose] polymerase. (536 aa)
COPS4COP9 signalosome subunit 4. (371 aa)
Yy1Uncharacterized protein. (195 aa)
RFC5Replication factor C subunit 5. (340 aa)
COPS6COP9 signalosome subunit 6. (325 aa)
H0VXB5_CAVPOUbiquitin-like domain-containing protein. (140 aa)
SUMO3Small ubiquitin-related modifier. (109 aa)
KCTD2Potassium channel tetramerization domain containing 2. (264 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
H0VSL9_CAVPOSsl1 domain-containing protein. (160 aa)
CDK7Cyclin dependent kinase 7. (335 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
PARP3Poly [ADP-ribose] polymerase. (533 aa)
H0VPN0_CAVPOC1_4 domain-containing protein. (286 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
DDB2Damage specific DNA binding protein 2. (289 aa)
LOC106026468UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
Ino80bPAPA-1 domain-containing protein. (373 aa)
RFC2Replication factor C subunit 2. (352 aa)
Cetn2Uncharacterized protein. (172 aa)
INO80EINO80 complex subunit E. (244 aa)
ATAD5ATPase family AAA domain containing 5. (1831 aa)
COPS5COP9 signalosome subunit 5. (334 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (602 aa)
TFPTTCF3 fusion partner. (257 aa)
INO80INO80 complex ATPase subunit. (1558 aa)
RFC4Replication factor C subunit 4. (363 aa)
MCRS1Microspherule protein 1. (462 aa)
H0VI45_CAVPOzf-C3Hc3H domain-containing protein. (414 aa)
USP45Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (591 aa)
GTF2H3General transcription factor IIH subunit 3. (309 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (897 aa)
H0VDH6_CAVPOVWFA domain-containing protein. (365 aa)
RPA2Replication protein A2. (270 aa)
RFC3Replication factor C subunit 3. (220 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
PIAS1Protein inhibitor of activated STAT 1. (651 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
Pold3Uncharacterized protein. (466 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (923 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
H0V698_CAVPOC2H2-type domain-containing protein. (374 aa)
COPS3COP9 signalosome subunit 3. (423 aa)
VWA5AVon Willebrand factor A domain containing 5A. (798 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
RFC1Replication factor C subunit 1. (1153 aa)
COPS2COP9 signalosome subunit 2. (443 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1203 aa)
RPAP3RNA polymerase II associated protein 3. (665 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (623 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (781 aa)
GPS1G protein pathway suppressor 1. (487 aa)
XPAXPA, DNA damage recognition and repair factor. (263 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
ERCC5ERCC excision repair 5, endonuclease. (1059 aa)
POLKDNA polymerase kappa. (540 aa)
NFRKBNuclear factor related to kappaB binding protein. (1298 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
COPS7ACOP9 signalosome subunit 7A. (275 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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