STRINGSTRING
XAB2 XAB2 PCNA PCNA H0VDH6_CAVPO H0VDH6_CAVPO RPA2 RPA2 RFC3 RFC3 CUL4A CUL4A H0V9L4_CAVPO H0V9L4_CAVPO Phf3 Phf3 Pold3 Pold3 TCEA1 TCEA1 Rps27a Rps27a H0V698_CAVPO H0V698_CAVPO EP300 EP300 Ercc8 Ercc8 POLR2C POLR2C POLE2 POLE2 RFC1 RFC1 Lig1 Lig1 USP40 USP40 USP7 USP7 POLR2D POLR2D NRDE2 NRDE2 ERCC3 ERCC3 MEIOB MEIOB POLR2E POLR2E Polr2j Polr2j POLK POLK AQR AQR Tcea3 Tcea3 UBA52 UBA52 RPA1 RPA1 POLR2G POLR2G Ubc Ubc ENSCPOP00000031632 ENSCPOP00000031632 XRCC1 XRCC1 ERCC6 ERCC6 POLR2K POLR2K POLR2F POLR2F UBB UBB ENSCPOP00000029727 ENSCPOP00000029727 GTF2H5 GTF2H5 HMGN1 HMGN1 ENSCPOP00000028285 ENSCPOP00000028285 ENSCPOP00000028206 ENSCPOP00000028206 RCBTB1 RCBTB1 ZNF830 ZNF830 PPIE PPIE Hmgn2 Hmgn2 POLR2H POLR2H RCBTB2 RCBTB2 DDB1 DDB1 TCEANC2 TCEANC2 RPA3 RPA3 GTF2H1 GTF2H1 TCEA2 TCEA2 LOC100732574 LOC100732574 CUL4B CUL4B RBX1 RBX1 POLR2B POLR2B ERCC2 ERCC2 POLR2L POLR2L CCNH CCNH POLE3 POLE3 Pold4 Pold4 POLE4 POLE4 POLD1 POLD1 GTF2H4 GTF2H4 H0WDT2_CAVPO H0WDT2_CAVPO PRPF19 PRPF19 H0WAD6_CAVPO H0WAD6_CAVPO LOC100730459 LOC100730459 POLD2 POLD2 RFC5 RFC5 H0VSL9_CAVPO H0VSL9_CAVPO H0VSI3_CAVPO H0VSI3_CAVPO POLR2A POLR2A Isy1 Isy1 CDK7 CDK7 MNAT1 MNAT1 TCEANC TCEANC H0VPN0_CAVPO H0VPN0_CAVPO UVSSA UVSSA POLE POLE LIG3 LIG3 RFC2 RFC2 POLR2I POLR2I ATAD5 ATAD5 RFC4 RFC4 GTF2H3 GTF2H3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XAB2XPA binding protein 2. (855 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
H0VDH6_CAVPOVWFA domain-containing protein. (365 aa)
RPA2Replication protein A2. (270 aa)
RFC3Replication factor C subunit 3. (220 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
H0V9L4_CAVPOTFIIS central domain-containing protein. (512 aa)
Phf3TFIIS central domain-containing protein. (351 aa)
Pold3Uncharacterized protein. (466 aa)
TCEA1Transcription elongation factor A1. (305 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
H0V698_CAVPOC2H2-type domain-containing protein. (374 aa)
EP300E1A binding protein p300. (2425 aa)
Ercc8WD_REPEATS_REGION domain-containing protein. (396 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
RFC1Replication factor C subunit 1. (1153 aa)
Lig1DNA ligase. (909 aa)
USP40Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1232 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1101 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
NRDE2NRDE-2, necessary for RNA interference, domain containing. (1165 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (781 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
Polr2jRNA polymerase II subunit J. (117 aa)
POLKDNA polymerase kappa. (540 aa)
AQRAquarius intron-binding spliceosomal factor. (1251 aa)
Tcea3Uncharacterized protein. (349 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
UbcUncharacterized protein. (159 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
XRCC1X-ray repair cross complementing 1. (629 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1473 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
POLR2FRNA polymerase II subunit F. (127 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
ENSCPOP00000029727C1_4 domain-containing protein. (309 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
HMGN1High mobility group nucleosome binding domain 1. (130 aa)
ENSCPOP00000028285SPOC domain-containing protein. (111 aa)
ENSCPOP00000028206Uncharacterized protein. (347 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
ZNF830Zinc finger protein 830. (363 aa)
PPIEPeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (301 aa)
Hmgn2Uncharacterized protein. (95 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
TCEANC2Transcription elongation factor A N-terminal and central domain containing 2. (208 aa)
RPA3Replication protein A3. (121 aa)
GTF2H1General transcription factor IIH subunit 1. (556 aa)
TCEA2Transcription elongation factor A2. (299 aa)
LOC100732574General transcription factor IIH subunit. (395 aa)
CUL4BCullin 4B; Belongs to the cullin family. (936 aa)
RBX1Ring-box 1. (108 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
Pold4Uncharacterized protein. (107 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (116 aa)
POLD1DNA polymerase. (1134 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (485 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
PRPF19Pre-mRNA processing factor 19. (513 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
LOC100730459Uncharacterized protein. (280 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
RFC5Replication factor C subunit 5. (340 aa)
H0VSL9_CAVPOSsl1 domain-containing protein. (160 aa)
H0VSI3_CAVPODNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1833 aa)
Isy1Uncharacterized protein. (285 aa)
CDK7Cyclin dependent kinase 7. (335 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
TCEANCTranscription elongation factor A N-terminal and central domain containing. (371 aa)
H0VPN0_CAVPOC1_4 domain-containing protein. (286 aa)
UVSSAUV stimulated scaffold protein A. (730 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
LIG3DNA ligase. (1012 aa)
RFC2Replication factor C subunit 2. (352 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
ATAD5ATPase family AAA domain containing 5. (1831 aa)
RFC4Replication factor C subunit 4. (363 aa)
GTF2H3General transcription factor IIH subunit 3. (309 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.