STRINGSTRING
RPA1 RPA1 Ubc Ubc FANCC FANCC ENSCPOP00000031632 ENSCPOP00000031632 ERCC1 ERCC1 UBB UBB NUTF2 NUTF2 EME2 EME2 RPA3 RPA3 CENPS CENPS WDR48 WDR48 Dclre1b Dclre1b Cenpx Cenpx SLX4 SLX4 H0WDT2_CAVPO H0WDT2_CAVPO Slx1a Slx1a EME1 EME1 H0WAD6_CAVPO H0WAD6_CAVPO PROSER1 PROSER1 USP1 USP1 FANCF FANCF FANCL FANCL DCLRE1A DCLRE1A FAN1 FAN1 FANCG FANCG FAAP24 FAAP24 UBE2T UBE2T RPA2 RPA2 MUS81 MUS81 FANCI FANCI ATR ATR Rps27a Rps27a FANCD2 FANCD2 FANCE FANCE ERCC4 ERCC4 FANCA FANCA FAAP100 FAAP100 POLN POLN MEIOB MEIOB FANCM FANCM ATRIP ATRIP UBA52 UBA52
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
UbcUncharacterized protein. (159 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (569 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
NUTF2Nuclear transport factor 2. (127 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (371 aa)
RPA3Replication protein A3. (121 aa)
CENPSCentromere protein S. (135 aa)
WDR48WD repeat domain 48. (676 aa)
Dclre1bLactamase_B domain-containing protein. (190 aa)
CenpxUncharacterized protein. (79 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1738 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
Slx1aStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (266 aa)
EME1Essential meiotic structure-specific endonuclease 1. (578 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
PROSER1Proline and serine rich 1. (947 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (764 aa)
FANCFFA complementation group F. (322 aa)
FANCLFA complementation group L. (355 aa)
DCLRE1ADNA cross-link repair 1A. (913 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (987 aa)
FANCGFA complementation group G. (626 aa)
FAAP24FA core complex associated protein 24. (215 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (205 aa)
RPA2Replication protein A2. (270 aa)
MUS81MUS81 structure-specific endonuclease subunit. (562 aa)
FANCIFA complementation group I. (1313 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
FANCD2FA complementation group D2. (1448 aa)
FANCEFA complementation group E. (531 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
FANCAFA complementation group A. (1416 aa)
FAAP100FA core complex associated protein 100. (856 aa)
POLNDNA polymerase nu. (860 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
FANCMFA complementation group M. (1971 aa)
ATRIPATR interacting protein. (792 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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