STRINGSTRING
PPP2R5C PPP2R5C UBA52 UBA52 PHF20 PHF20 MLST8 MLST8 USP7 USP7 PDPK1 PDPK1 MTOR MTOR RNF34 RNF34 TXNDC11 TXNDC11 PPP2CB PPP2CB Cdk1 Cdk1 Rps27a Rps27a CHEK2 CHEK2 MDM4 MDM4 LOC100734047 LOC100734047 CDK2 CDK2 CCNA2 CCNA2 Ubc Ubc ENSCPOP00000031632 ENSCPOP00000031632 AKT2 AKT2 ENSCPOP00000030888 ENSCPOP00000030888 CCNG1 CCNG1 UBB UBB TP53 TP53 SGK1 SGK1 ENSCPOP00000029129 ENSCPOP00000029129 RFFL RFFL MAPKAP1 MAPKAP1 USP2 USP2 PRR5 PRR5 DAXX DAXX AKT1 AKT1 RICTOR RICTOR ATM ATM PPP2R1B PPP2R1B PPP2CA PPP2CA MDM2 MDM2 CCNA1 CCNA1 H0WDT2_CAVPO H0WDT2_CAVPO H0WAD6_CAVPO H0WAD6_CAVPO H0W426_CAVPO H0W426_CAVPO H0W160_CAVPO H0W160_CAVPO AKT3 AKT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (589 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
PHF20PHD finger protein 20. (1007 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1101 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (550 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
RNF34Ring finger protein 34. (376 aa)
TXNDC11Thioredoxin domain containing 11. (948 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
Cdk1Protein kinase domain-containing protein. (240 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
CHEK2Checkpoint kinase 2. (546 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (485 aa)
LOC100734047Uncharacterized protein. (567 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (429 aa)
UbcUncharacterized protein. (159 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSCPOP00000030888Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (238 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
ENSCPOP00000029129Protein kinase domain-containing protein. (254 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (398 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (611 aa)
PRR5Proline rich 5. (358 aa)
DAXXDeath domain associated protein. (756 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1471 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (696 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (420 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
H0W426_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. (416 aa)
H0W160_CAVPOUncharacterized protein. (589 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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