STRINGSTRING
PTPRJ PTPRJ UBA52 UBA52 HGF HGF USP8 USP8 LRIG1 LRIG1 STAM2 STAM2 SH3GL3 SH3GL3 Rps27a Rps27a SH3KBP1 SH3KBP1 PTPN2 PTPN2 STAM STAM MET MET SH3GL2 SH3GL2 HGS HGS SH3GL1 SH3GL1 H0WAD6_CAVPO H0WAD6_CAVPO H0WDT2_CAVPO H0WDT2_CAVPO PTPN1 PTPN1 CBL CBL UBB UBB EPS15 EPS15 ENSCPOP00000031632 ENSCPOP00000031632 GRB2 GRB2 Ubc Ubc
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPRJProtein tyrosine phosphatase receptor type J. (1311 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1081 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1089 aa)
STAM2Signal transducing adaptor molecule 2. (519 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (346 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (716 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (364 aa)
STAMSignal transducing adaptor molecule. (537 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (376 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (778 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (359 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (432 aa)
CBLCbl proto-oncogene. (894 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (935 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
UbcUncharacterized protein. (159 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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