STRINGSTRING
Rps27a Rps27a PSMB7 PSMB7 ORC4 ORC4 PSMC6 PSMC6 PSMD11 PSMD11 CDK2 CDK2 MCM2 MCM2 CDC6 CDC6 CCNA2 CCNA2 PSMD8 PSMD8 PSMD7 PSMD7 PSMC5 PSMC5 PSME4 PSME4 PSMA8 PSMA8 Skp2 Skp2 PSMA5 PSMA5 PSMF1 PSMF1 PSMA7 PSMA7 ENSCPOP00000032613 ENSCPOP00000032613 PSME3 PSME3 Psma2 Psma2 Ubc Ubc PSME2 PSME2 ENSCPOP00000031632 ENSCPOP00000031632 PSMC1 PSMC1 UBB UBB PSMA6 PSMA6 PSMB2 PSMB2 ENSCPOP00000029251 ENSCPOP00000029251 PSMD12 PSMD12 PSMD4 PSMD4 PSMD14 PSMD14 Mcm8 Mcm8 Tm4sf19 Tm4sf19 RBX1 RBX1 PSMD2 PSMD2 PSMC3 PSMC3 ORC5 ORC5 PSME1 PSME1 ENSCPOP00000023065 ENSCPOP00000023065 PSMA3 PSMA3 PSMD1 PSMD1 MCM7 MCM7 CCNA1 CCNA1 H0WDT2_CAVPO H0WDT2_CAVPO PSMB10 PSMB10 H0WAD6_CAVPO H0WAD6_CAVPO PSMD5 PSMD5 PSMB11 PSMB11 PSMB3 PSMB3 CDT1 CDT1 MCM5 MCM5 PSMA4 PSMA4 Psmd9 Psmd9 CUL1 CUL1 H0VWS1_CAVPO H0VWS1_CAVPO PSMC2 PSMC2 PSMA1 PSMA1 PSMB4 PSMB4 ORC3 ORC3 PSMD3 PSMD3 Psmd10 Psmd10 UBA52 UBA52 PSMB8 PSMB8 MCM3 MCM3 PSMB1 PSMB1 PSMB6 PSMB6 PSMB9 PSMB9 PSMD13 PSMD13 MCM4 MCM4 ORC6 ORC6 PSMC4 PSMC4 ORC2 ORC2 MCM6 MCM6 ORC1 ORC1 PSMB5 PSMB5 SKP1 SKP1 MCM9 MCM9 PSMD6 PSMD6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
PSMB7Proteasome subunit beta. (277 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (419 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
MCM2DNA helicase; Belongs to the MCM family. (898 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (429 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSME4Proteasome activator subunit 4. (1827 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
Skp2F-box domain-containing protein. (424 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
ENSCPOP00000032613F-box domain-containing protein. (390 aa)
PSME3Proteasome activator subunit 3. (254 aa)
Psma2Proteasome subunit alpha type. (234 aa)
UbcUncharacterized protein. (159 aa)
PSME2Proteasome activator subunit 2. (239 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMB2Proteasome subunit beta. (201 aa)
ENSCPOP00000029251Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
Mcm8MCM domain-containing protein; Belongs to the MCM family. (833 aa)
Tm4sf19Uncharacterized protein. (232 aa)
RBX1Ring-box 1. (108 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
ORC5Origin recognition complex subunit 5. (414 aa)
PSME1Proteasome activator subunit 1. (249 aa)
ENSCPOP00000023065ANK_REP_REGION domain-containing protein. (179 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (420 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
PSMB10Proteasome subunit beta. (273 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
PSMB11Proteasome subunit beta. (297 aa)
PSMB3Proteasome subunit beta. (207 aa)
CDT1Chromatin licensing and DNA replication factor 1. (549 aa)
MCM5DNA helicase; Belongs to the MCM family. (731 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
Psmd9PDZ domain-containing protein. (223 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
H0VWS1_CAVPOANK_REP_REGION domain-containing protein. (213 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
PSMA1Proteasome subunit alpha type. (270 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
ORC3Origin recognition complex subunit 3. (710 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
Psmd10ANK_REP_REGION domain-containing protein. (232 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
PSMB8Proteasome subunit beta. (273 aa)
MCM3DNA helicase; Belongs to the MCM family. (810 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (315 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
ORC6Origin recognition complex subunit 6. (293 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (837 aa)
PSMB5Proteasome subunit beta. (263 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (162 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1117 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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