35 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ORC5	Origin recognition complex subunit 5. (414 aa)
	MCM3	DNA helicase; Belongs to the MCM family. (810 aa)
	MEIOB	Meiosis specific with OB-fold. (471 aa)
	Pola2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
	POLA1	DNA polymerase. (1467 aa)
	MCM4	DNA helicase; Belongs to the MCM family. (863 aa)
	ORC6	Origin recognition complex subunit 6. (293 aa)
	PRIM2	DNA primase subunit 2. (432 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	ORC2	Origin recognition complex subunit 2. (577 aa)
	MCM6	DNA helicase; Belongs to the MCM family. (821 aa)
	GMNN	Geminin DNA replication inhibitor. (209 aa)
	ORC1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (837 aa)
	MCM9	Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1117 aa)
	MCM10	Minichromosome maintenance 10 replication initiation factor. (834 aa)
	ORC3	Origin recognition complex subunit 3. (710 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
	CDC7	Cell division cycle 7. (560 aa)
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa)
	MCM2	DNA helicase; Belongs to the MCM family. (898 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	RPA2	Replication protein A2. (270 aa)
	ORC4	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (419 aa)
	DBF4	DBF4 zinc finger. (675 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	Mcm8	MCM domain-containing protein; Belongs to the MCM family. (833 aa)
	RPA3	Replication protein A3. (121 aa)
	Tm4sf19	Uncharacterized protein. (232 aa)
	CDC45	Cell division cycle 45. (566 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (116 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
	CDT1	Chromatin licensing and DNA replication factor 1. (549 aa)
	MCM5	DNA helicase; Belongs to the MCM family. (731 aa)
	Prim1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC45	CDC6	ENSCPOP00000025333	ENSCPOP00000009254	Cell division cycle 45.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.984
CDC45	CDC7	ENSCPOP00000025333	ENSCPOP00000011478	Cell division cycle 45.	Cell division cycle 7.	0.934
CDC45	CDK2	ENSCPOP00000025333	ENSCPOP00000008931	Cell division cycle 45.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.913
CDC45	CDT1	ENSCPOP00000025333	ENSCPOP00000018827	Cell division cycle 45.	Chromatin licensing and DNA replication factor 1.	0.973
CDC45	DBF4	ENSCPOP00000025333	ENSCPOP00000007449	Cell division cycle 45.	DBF4 zinc finger.	0.930
CDC45	GMNN	ENSCPOP00000025333	ENSCPOP00000007194	Cell division cycle 45.	Geminin DNA replication inhibitor.	0.682
CDC45	MCM10	ENSCPOP00000025333	ENSCPOP00000006828	Cell division cycle 45.	Minichromosome maintenance 10 replication initiation factor.	0.999
CDC45	MCM2	ENSCPOP00000025333	ENSCPOP00000009081	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	MCM3	ENSCPOP00000025333	ENSCPOP00000000780	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	MCM4	ENSCPOP00000025333	ENSCPOP00000003322	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	MCM5	ENSCPOP00000025333	ENSCPOP00000018592	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	MCM6	ENSCPOP00000025333	ENSCPOP00000004155	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	MCM7	ENSCPOP00000025333	ENSCPOP00000021536	Cell division cycle 45.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
CDC45	MCM9	ENSCPOP00000025333	ENSCPOP00000004899	Cell division cycle 45.	Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family.	0.994
CDC45	MEIOB	ENSCPOP00000025333	ENSCPOP00000001396	Cell division cycle 45.	Meiosis specific with OB-fold.	0.843
CDC45	Mcm8	ENSCPOP00000025333	ENSCPOP00000027373	Cell division cycle 45.	MCM domain-containing protein; Belongs to the MCM family.	0.982
CDC45	ORC1	ENSCPOP00000025333	ENSCPOP00000004564	Cell division cycle 45.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.993
CDC45	ORC2	ENSCPOP00000025333	ENSCPOP00000004102	Cell division cycle 45.	Origin recognition complex subunit 2.	0.979
CDC45	ORC3	ENSCPOP00000025333	ENSCPOP00000013643	Cell division cycle 45.	Origin recognition complex subunit 3.	0.954
CDC45	ORC4	ENSCPOP00000025333	ENSCPOP00000007709	Cell division cycle 45.	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.934