STRINGSTRING
ANAPC1 ANAPC1 PSMD12 PSMD12 ENSCPOP00000029251 ENSCPOP00000029251 ENSCPOP00000031632 ENSCPOP00000031632 PSMC1 PSMC1 ANAPC15 ANAPC15 CDC27 CDC27 CCNE1 CCNE1 MCM6 MCM6 ORC2 ORC2 PSMC4 PSMC4 ORC6 ORC6 MCM4 MCM4 PSMD13 PSMD13 UBE2E1 UBE2E1 PSMB9 PSMB9 PSMB6 PSMB6 PSMB1 PSMB1 MCM3 MCM3 PSMB8 PSMB8 UBA52 UBA52 ENSCPOP00000032613 ENSCPOP00000032613 PSME3 PSME3 Psma2 Psma2 Ubc Ubc PSMB2 PSMB2 PSMA6 PSMA6 FAM89B FAM89B UBB UBB ENSCPOP00000030705 ENSCPOP00000030705 PSME2 PSME2 PSMB7 PSMB7 GMNN GMNN ORC4 ORC4 PSMC6 PSMC6 ANAPC2 ANAPC2 PSMD11 PSMD11 CDK2 CDK2 PSMD6 PSMD6 Rps27a Rps27a MCM9 MCM9 CDC16 CDC16 SKP1 SKP1 ORC1 ORC1 MCM2 MCM2 CDC6 CDC6 CCNA2 CCNA2 CDC23 CDC23 PSMD8 PSMD8 PSMD7 PSMD7 PSMC5 PSMC5 ANAPC5 ANAPC5 PSME4 PSME4 PSMA8 PSMA8 UBE2S UBE2S ANAPC4 ANAPC4 Skp2 Skp2 Ccne2 Ccne2 PSMA5 PSMA5 Anapc11 Anapc11 PSMF1 PSMF1 PSMB5 PSMB5 PSMA7 PSMA7 TM7SF3 TM7SF3 Psmd10 Psmd10 PSMD3 PSMD3 ORC3 ORC3 PSMB4 PSMB4 PSMA1 PSMA1 ANAPC7 ANAPC7 PSMC2 PSMC2 H0VWS1_CAVPO H0VWS1_CAVPO H0VZC1_CAVPO H0VZC1_CAVPO CUL1 CUL1 Psmd9 Psmd9 PSMA4 PSMA4 MCM5 MCM5 CDT1 CDT1 PSMB3 PSMB3 PSMB11 PSMB11 PSMD5 PSMD5 H0WAD6_CAVPO H0WAD6_CAVPO PSMB10 PSMB10 H0WDT2_CAVPO H0WDT2_CAVPO UBE2D1 UBE2D1 CCNA1 CCNA1 MCM7 MCM7 UBE2C UBE2C PSMD1 PSMD1 FAM89A FAM89A PSMA3 PSMA3 ANAPC10 ANAPC10 ENSCPOP00000023065 ENSCPOP00000023065 FZR1 FZR1 PSME1 PSME1 ORC5 ORC5 PSMC3 PSMC3 PSMD2 PSMD2 RBX1 RBX1 Tm4sf19 Tm4sf19 Mcm8 Mcm8 CDC26 CDC26 PSMD14 PSMD14 PSMD4 PSMD4 ANAPC16 ANAPC16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANAPC1Anaphase promoting complex subunit 1. (1941 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
ENSCPOP00000029251Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
ANAPC15Anaphase promoting complex subunit 15. (134 aa)
CDC27Cell division cycle 27. (825 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
ORC6Origin recognition complex subunit 6. (293 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (315 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMB1Proteasome subunit beta. (241 aa)
MCM3DNA helicase; Belongs to the MCM family. (810 aa)
PSMB8Proteasome subunit beta. (273 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ENSCPOP00000032613F-box domain-containing protein. (390 aa)
PSME3Proteasome activator subunit 3. (254 aa)
Psma2Proteasome subunit alpha type. (234 aa)
UbcUncharacterized protein. (159 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
FAM89BFamily with sequence similarity 89 member B. (189 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
ENSCPOP00000030705CYCLIN domain-containing protein; Belongs to the cyclin family. (341 aa)
PSME2Proteasome activator subunit 2. (239 aa)
PSMB7Proteasome subunit beta. (277 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (419 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (827 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1117 aa)
CDC16Cell division cycle 16. (620 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (162 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (837 aa)
MCM2DNA helicase; Belongs to the MCM family. (898 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (429 aa)
CDC23Cell division cycle 23. (597 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
PSME4Proteasome activator subunit 4. (1827 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (214 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
Skp2F-box domain-containing protein. (424 aa)
Ccne2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
Anapc11RING-type domain-containing protein. (84 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
Psmd10ANK_REP_REGION domain-containing protein. (232 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
ORC3Origin recognition complex subunit 3. (710 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
PSMA1Proteasome subunit alpha type. (270 aa)
ANAPC7Anaphase promoting complex subunit 7. (555 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
H0VWS1_CAVPOANK_REP_REGION domain-containing protein. (213 aa)
H0VZC1_CAVPOUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
Psmd9PDZ domain-containing protein. (223 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
MCM5DNA helicase; Belongs to the MCM family. (731 aa)
CDT1Chromatin licensing and DNA replication factor 1. (549 aa)
PSMB3Proteasome subunit beta. (207 aa)
PSMB11Proteasome subunit beta. (297 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
PSMB10Proteasome subunit beta. (273 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (139 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (420 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
FAM89AFamily with sequence similarity 89 member A. (174 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
ENSCPOP00000023065ANK_REP_REGION domain-containing protein. (179 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
PSME1Proteasome activator subunit 1. (249 aa)
ORC5Origin recognition complex subunit 5. (414 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
RBX1Ring-box 1. (108 aa)
Tm4sf19Uncharacterized protein. (232 aa)
Mcm8MCM domain-containing protein; Belongs to the MCM family. (833 aa)
CDC26Cell division cycle 26. (85 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
ANAPC16Anaphase promoting complex subunit 16. (118 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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