STRINGSTRING
RPA3 RPA3 FEN1 FEN1 RPA1 RPA1 POLD2 POLD2 POLD1 POLD1 Pold4 Pold4 Prim1 Prim1 MAML1 MAML1 PCNA PCNA RPA2 RPA2 Pold3 Pold3 PRIM2 PRIM2 POLA1 POLA1 DNA2 DNA2 Pola2 Pola2 MEIOB MEIOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA3Replication protein A3. (121 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
POLD1DNA polymerase. (1134 aa)
Pold4Uncharacterized protein. (107 aa)
Prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
MAML1Mastermind like transcriptional coactivator 1. (794 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RPA2Replication protein A2. (270 aa)
Pold3Uncharacterized protein. (466 aa)
PRIM2DNA primase subunit 2. (432 aa)
POLA1DNA polymerase. (1467 aa)
DNA2DNA replication helicase/nuclease 2. (1021 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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