STRINGSTRING
H0VSI3_CAVPO H0VSI3_CAVPO FEN1 FEN1 RCBTB1 RCBTB1 RCBTB2 RCBTB2 RPA3 RPA3 DNA2 DNA2 Pold4 Pold4 POLD1 POLD1 POLD2 POLD2 RFC5 RFC5 Prim1 Prim1 RFC2 RFC2 ATAD5 ATAD5 RFC4 RFC4 MAML1 MAML1 PCNA PCNA RPA2 RPA2 RFC3 RFC3 Pold3 Pold3 RFC1 RFC1 Lig1 Lig1 PRIM2 PRIM2 POLA1 POLA1 Pola2 Pola2 MEIOB MEIOB RPA1 RPA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H0VSI3_CAVPODNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
RPA3Replication protein A3. (121 aa)
DNA2DNA replication helicase/nuclease 2. (1021 aa)
Pold4Uncharacterized protein. (107 aa)
POLD1DNA polymerase. (1134 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
RFC5Replication factor C subunit 5. (340 aa)
Prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
RFC2Replication factor C subunit 2. (352 aa)
ATAD5ATPase family AAA domain containing 5. (1831 aa)
RFC4Replication factor C subunit 4. (363 aa)
MAML1Mastermind like transcriptional coactivator 1. (794 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RPA2Replication protein A2. (270 aa)
RFC3Replication factor C subunit 3. (220 aa)
Pold3Uncharacterized protein. (466 aa)
RFC1Replication factor C subunit 1. (1153 aa)
Lig1DNA ligase. (909 aa)
PRIM2DNA primase subunit 2. (432 aa)
POLA1DNA polymerase. (1467 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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