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PSMC1 PSMC1 ENSCPOP00000031632 ENSCPOP00000031632 PSME2 PSME2 Ubc Ubc Psma2 Psma2 PSME3 PSME3 ENSCPOP00000032613 ENSCPOP00000032613 CDKN1B CDKN1B RPA1 RPA1 FNBP4 FNBP4 UBA52 UBA52 PSMB8 PSMB8 MCM3 MCM3 PSMB1 PSMB1 PSMB6 PSMB6 MEIOB MEIOB PPP4R1 PPP4R1 Pola2 Pola2 PSMB9 PSMB9 POLA1 POLA1 PPP2R3A PPP2R3A WEE1 WEE1 PSMD13 PSMD13 MCM4 MCM4 ORC6 ORC6 PRIM2 PRIM2 PSMC4 PSMC4 POLE2 POLE2 ORC2 ORC2 MCM6 MCM6 PPP2R3C PPP2R3C CCNE1 CCNE1 ORC1 ORC1 SKP1 SKP1 PPP2CB PPP2CB MCM9 MCM9 Rps27a Rps27a PSMD6 PSMD6 PTK6 PTK6 MCM10 MCM10 PSMB7 PSMB7 GMNN GMNN DBF4 DBF4 ORC4 ORC4 LOC100734047 LOC100734047 RB1 RB1 RPA2 RPA2 PSMC6 PSMC6 PSMD11 PSMD11 CDK2 CDK2 MCM2 MCM2 CDC6 CDC6 CCNA2 CCNA2 CABLES1 CABLES1 PSMD8 PSMD8 PSMD7 PSMD7 PSMC5 PSMC5 CDC7 CDC7 Skp2 Skp2 Ccne2 Ccne2 POLE POLE PSMA5 PSMA5 PSMF1 PSMF1 PPP4R4 PPP4R4 PSMB5 PSMB5 PSMA7 PSMA7 MNAT1 MNAT1 CDK7 CDK7 Psmd10 Psmd10 PSMD3 PSMD3 ORC3 ORC3 PSMB4 PSMB4 PSMA1 PSMA1 RELCH RELCH AKT3 AKT3 Wee2 Wee2 Prim1 Prim1 PSMC2 PSMC2 H0VWS1_CAVPO H0VWS1_CAVPO CUL1 CUL1 H0W160_CAVPO H0W160_CAVPO Psmd9 Psmd9 PSMA4 PSMA4 MCM5 MCM5 CDT1 CDT1 PSMB3 PSMB3 PSMD5 PSMD5 H0W9P9_CAVPO H0W9P9_CAVPO H0WAD6_CAVPO H0WAD6_CAVPO PSMB10 PSMB10 H0WDT2_CAVPO H0WDT2_CAVPO CCNA1 CCNA1 MCM7 MCM7 LOC100733575 LOC100733575 CDK4 CDK4 POLE4 POLE4 PSMD1 PSMD1 POLE3 POLE3 PSMA3 PSMA3 ENSCPOP00000023065 ENSCPOP00000023065 PSME1 PSME1 CCNH CCNH ORC5 ORC5 PPP2CA PPP2CA PSMC3 PSMC3 PPP2R1B PPP2R1B PSMD2 PSMD2 CDC45 CDC45 Tm4sf19 Tm4sf19 CDKN1A CDKN1A AKT1 AKT1 CCND1 CCND1 RPA3 RPA3 Mcm8 Mcm8 PSMD14 PSMD14 PSMD4 PSMD4 CKS2 CKS2 PSMD12 PSMD12 ENSCPOP00000029251 ENSCPOP00000029251 PSMB2 PSMB2 CKS1B CKS1B PSMA6 PSMA6 UBB UBB ENSCPOP00000030079 ENSCPOP00000030079 ENSCPOP00000030705 ENSCPOP00000030705 AKT2 AKT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
PSME2Proteasome activator subunit 2. (239 aa)
UbcUncharacterized protein. (159 aa)
Psma2Proteasome subunit alpha type. (234 aa)
PSME3Proteasome activator subunit 3. (254 aa)
ENSCPOP00000032613F-box domain-containing protein. (390 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
FNBP4Formin binding protein 4. (1044 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
PSMB8Proteasome subunit beta. (273 aa)
MCM3DNA helicase; Belongs to the MCM family. (810 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB6Proteasome subunit beta. (239 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (942 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
PSMB9Proteasome subunit beta. (219 aa)
POLA1DNA polymerase. (1467 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1122 aa)
WEE1Wee1-like protein kinase. (612 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (315 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
ORC6Origin recognition complex subunit 6. (293 aa)
PRIM2DNA primase subunit 2. (432 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (837 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (162 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1117 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PTK6Tyrosine-protein kinase. (451 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (834 aa)
PSMB7Proteasome subunit beta. (277 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
DBF4DBF4 zinc finger. (675 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (419 aa)
LOC100734047Uncharacterized protein. (567 aa)
RB1RB transcriptional corepressor 1. (840 aa)
RPA2Replication protein A2. (270 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
MCM2DNA helicase; Belongs to the MCM family. (898 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (429 aa)
CABLES1Cdk5 and Abl enzyme substrate 1. (443 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
CDC7Cell division cycle 7. (560 aa)
Skp2F-box domain-containing protein. (424 aa)
Ccne2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (832 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
CDK7Cyclin dependent kinase 7. (335 aa)
Psmd10ANK_REP_REGION domain-containing protein. (232 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
ORC3Origin recognition complex subunit 3. (710 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
PSMA1Proteasome subunit alpha type. (270 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1097 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
Wee2Wee1-like protein kinase. (557 aa)
Prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
H0VWS1_CAVPOANK_REP_REGION domain-containing protein. (213 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
H0W160_CAVPOUncharacterized protein. (589 aa)
Psmd9PDZ domain-containing protein. (223 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
MCM5DNA helicase; Belongs to the MCM family. (731 aa)
CDT1Chromatin licensing and DNA replication factor 1. (549 aa)
PSMB3Proteasome subunit beta. (207 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
H0W9P9_CAVPOWee1-like protein kinase. (551 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
PSMB10Proteasome subunit beta. (273 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (420 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
LOC100733575Uncharacterized protein. (295 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (116 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
ENSCPOP00000023065ANK_REP_REGION domain-containing protein. (179 aa)
PSME1Proteasome activator subunit 1. (249 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
ORC5Origin recognition complex subunit 5. (414 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (696 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
CDC45Cell division cycle 45. (566 aa)
Tm4sf19Uncharacterized protein. (232 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (169 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
RPA3Replication protein A3. (121 aa)
Mcm8MCM domain-containing protein; Belongs to the MCM family. (833 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
ENSCPOP00000029251Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
PSMB2Proteasome subunit beta. (201 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
ENSCPOP00000030079Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (70 aa)
ENSCPOP00000030705CYCLIN domain-containing protein; Belongs to the cyclin family. (341 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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