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| | GINS3 | GINS complex subunit 3. (216 aa) |
| | ENSCPOP00000032613 | F-box domain-containing protein. (390 aa) |
| | PSME3 | Proteasome activator subunit 3. (254 aa) |
| | Psma2 | Proteasome subunit alpha type. (234 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | Ubc | Uncharacterized protein. (159 aa) |
| | PSME2 | Proteasome activator subunit 2. (239 aa) |
| | ENSCPOP00000031632 | Ubiquitin-like domain-containing protein. (141 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa) |
| | ANAPC15 | Anaphase promoting complex subunit 15. (134 aa) |
| | CDC27 | Cell division cycle 27. (825 aa) |
| | ENSCPOP00000030705 | CYCLIN domain-containing protein; Belongs to the cyclin family. (341 aa) |
| | UBB | Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa) |
| | FAM89B | Family with sequence similarity 89 member B. (189 aa) |
| | PSMA6 | Proteasome subunit alpha type. (246 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | ENSCPOP00000029251 | Uncharacterized protein; Belongs to the SKP1 family. (147 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (456 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1941 aa) |
| | ANAPC16 | Anaphase promoting complex subunit 16. (118 aa) |
| | PSMD4 | Proteasome 26S subunit, non-ATPase 4. (377 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | Mcm8 | MCM domain-containing protein; Belongs to the MCM family. (833 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | Tm4sf19 | Uncharacterized protein. (232 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa) |
| | ORC5 | Origin recognition complex subunit 5. (414 aa) |
| | PSME1 | Proteasome activator subunit 1. (249 aa) |
| | FZR1 | Fizzy and cell division cycle 20 related 1. (493 aa) |
| | ENSCPOP00000023065 | ANK_REP_REGION domain-containing protein. (179 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1021 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | Pold4 | Uncharacterized protein. (107 aa) |
| | FAM89A | Family with sequence similarity 89 member A. (174 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (116 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | POLD1 | DNA polymerase. (1134 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (420 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (139 aa) |
| | H0WDT2_CAVPO | Ubiquitin-like domain-containing protein. (127 aa) |
| | PSMB10 | Proteasome subunit beta. (273 aa) |
| | H0WAD6_CAVPO | Ubiquitin-like domain-containing protein. (111 aa) |
| | PSMD5 | Proteasome 26S subunit, non-ATPase 5. (504 aa) |
| | PSMB11 | Proteasome subunit beta. (297 aa) |
| | PSMB3 | Proteasome subunit beta. (207 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (549 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (731 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | PSMA4 | Proteasome subunit alpha type. (261 aa) |
| | Psmd9 | PDZ domain-containing protein. (223 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | H0VZC1_CAVPO | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa) |
| | H0VWS1_CAVPO | ANK_REP_REGION domain-containing protein. (213 aa) |
| | PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa) |
| | Prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (555 aa) |
| | PSMA1 | Proteasome subunit alpha type. (270 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa) |
| | ORC3 | Origin recognition complex subunit 3. (710 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (534 aa) |
| | H0VSI3_CAVPO | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa) |
| | Psmd10 | ANK_REP_REGION domain-containing protein. (232 aa) |
| | TM7SF3 | Transmembrane 7 superfamily member 3. (570 aa) |
| | PSMA7 | Proteasome endopeptidase complex. (248 aa) |
| | PSMB5 | Proteasome subunit beta. (263 aa) |
| | PSMF1 | Proteasome inhibitor subunit 1. (271 aa) |
| | Anapc11 | RING-type domain-containing protein. (84 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa) |
| | Ccne2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa) |
| | Skp2 | F-box domain-containing protein. (424 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa) |
| | UBE2S | Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (214 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | PSMA8 | Proteasome subunit alpha type. (250 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1831 aa) |
| | PSME4 | Proteasome activator subunit 4. (1827 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (755 aa) |
| | PSMC5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (322 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (350 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (429 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (898 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (827 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa) |
| | MAML1 | Mastermind like transcriptional coactivator 1. (794 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | RFC3 | Replication factor C subunit 3. (220 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (419 aa) |
| | GMNN | Geminin DNA replication inhibitor. (209 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | Pold3 | Uncharacterized protein. (466 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (389 aa) |
| | Rps27a | Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1117 aa) |
| | CDC16 | Cell division cycle 16. (620 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (162 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (837 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | RFC1 | Replication factor C subunit 1. (1153 aa) |
| | Lig1 | DNA ligase. (909 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | PRIM2 | DNA primase subunit 2. (432 aa) |
| | ORC6 | Origin recognition complex subunit 6. (293 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (315 aa) |
| | UBE2E1 | Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa) |
| | POLA1 | DNA polymerase. (1467 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | Pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | PSMB6 | Proteasome subunit beta. (239 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (810 aa) |
| | PSMB8 | Proteasome subunit beta. (273 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
