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| | TDRD3 | Tudor domain containing 3. (692 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | EXO1 | Exonuclease 1. (839 aa) |
| | ATRIP | ATR interacting protein. (792 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (696 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (371 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | BLM | BLM RecQ like helicase. (1405 aa) |
| | H0UX17_CAVPO | BRCT domain-containing protein. (722 aa) |
| | Rad50 | Zinc-hook domain-containing protein. (1275 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (514 aa) |
| | WRN | WRN RecQ like helicase. (1462 aa) |
| | WEE1 | Wee1-like protein kinase. (612 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1061 aa) |
| | Cdk1 | Protein kinase domain-containing protein. (240 aa) |
| | CHEK2 | Checkpoint kinase 2. (546 aa) |
| | Babam1 | Uncharacterized protein. (337 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1366 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (900 aa) |
| | H0VBD1_CAVPO | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (105 aa) |
| | RFC3 | Replication factor C subunit 3. (220 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (619 aa) |
| | RMI1 | RecQ mediated genome instability 1. (617 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (716 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4711 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (662 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (971 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | LOC106026468 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa) |
| | Brca1 | Uncharacterized protein. (79 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa) |
| | RECQL4 | RecQ like helicase 4. (1226 aa) |
| | RNF169 | Ring finger protein 169. (699 aa) |
| | Wee2 | Wee1-like protein kinase. (557 aa) |
| | Chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa) |
| | H0VYV4_CAVPO | Uncharacterized protein. (260 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (401 aa) |
| | LOC100728920 | Histone domain-containing protein; Belongs to the histone H2B family. (128 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | LOC111756490 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC100735042 | Histone domain-containing protein; Belongs to the histone H2B family. (125 aa) |
| | H0W9P9_CAVPO | Wee1-like protein kinase. (551 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (282 aa) |
| | H0WDH3_CAVPO | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa) |
| | LOC100735546 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | YWHAH | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1021 aa) |
| | ENSCPOP00000023362 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | LOC100717510 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCPOP00000023894 | annotation not available (126 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (291 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa) |
| | LOC100733876 | annotation not available (103 aa) |
| | ENSCPOP00000024311 | annotation not available (126 aa) |
| | ENSCPOP00000024347 | annotation not available (103 aa) |
| | HIST2H2BE | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCPOP00000024383 | annotation not available (126 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | ANKRD12 | Ankyrin repeat domain 12. (2046 aa) |
| | H2BC18 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC100728325 | annotation not available (103 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (233 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa) |
| | ENSCPOP00000025455 | Protein kinase domain-containing protein. (360 aa) |
| | LOC100713990 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCPOP00000026400 | annotation not available (125 aa) |
| | ENSCPOP00000026646 | annotation not available (126 aa) |
| | ENSCPOP00000027005 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (83 aa) |
| | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (358 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1392 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (145 aa) |
| | ENSCPOP00000028113 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (231 aa) |
| | ENSCPOP00000028155 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (102 aa) |
| | ENSCPOP00000029061 | annotation not available (126 aa) |
| | ENSCPOP00000029129 | Protein kinase domain-containing protein. (254 aa) |
| | ENSCPOP00000029297 | annotation not available (103 aa) |
| | Ywhae | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | ENSCPOP00000030090 | annotation not available (126 aa) |
| | ENSCPOP00000030888 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (238 aa) |
| | LOC106027456 | annotation not available (126 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1027 aa) |
| | LOC100731150 | annotation not available (103 aa) |
| | ENSCPOP00000033122 | MPN domain-containing protein. (250 aa) |
