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| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (389 aa) |
| | ENSCPOP00000033122 | MPN domain-containing protein. (250 aa) |
| | LOC100731150 | annotation not available (103 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1027 aa) |
| | PSME3 | Proteasome activator subunit 3. (254 aa) |
| | Psma2 | Proteasome subunit alpha type. (234 aa) |
| | Ubc | Uncharacterized protein. (159 aa) |
| | PSME2 | Proteasome activator subunit 2. (239 aa) |
| | ENSCPOP00000031632 | Ubiquitin-like domain-containing protein. (141 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa) |
| | Ccnb1 | annotation not available (423 aa) |
| | PIEZO1 | Piezo-type mechanosensitive ion channel component. (2499 aa) |
| | LOC106027456 | annotation not available (126 aa) |
| | ENSCPOP00000030888 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (238 aa) |
| | ENSCPOP00000030090 | annotation not available (126 aa) |
| | UBB | Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa) |
| | Ywhae | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa) |
| | PSMA6 | Proteasome subunit alpha type. (246 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | ENSCPOP00000029297 | annotation not available (103 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (456 aa) |
| | ENSCPOP00000029129 | Protein kinase domain-containing protein. (254 aa) |
| | ENSCPOP00000029061 | annotation not available (126 aa) |
| | ENSCPOP00000028155 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (102 aa) |
| | ENSCPOP00000028113 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (231 aa) |
| | PSMD4 | Proteasome 26S subunit, non-ATPase 4. (377 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (145 aa) |
| | Mcm8 | MCM domain-containing protein; Belongs to the MCM family. (833 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1392 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | EXO1 | Exonuclease 1. (839 aa) |
| | ATRIP | ATR interacting protein. (792 aa) |
| | PSMB8 | Proteasome subunit beta. (273 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (696 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (810 aa) |
| | WDR41 | WD repeat domain 41. (462 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (371 aa) |
| | PSMB6 | Proteasome subunit beta. (239 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | BLM | BLM RecQ like helicase. (1405 aa) |
| | H0UX17_CAVPO | BRCT domain-containing protein. (722 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | Rad50 | Zinc-hook domain-containing protein. (1275 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (514 aa) |
| | WRN | WRN RecQ like helicase. (1462 aa) |
| | WEE1 | Wee1-like protein kinase. (612 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (315 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | ORC6 | Origin recognition complex subunit 6. (293 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1061 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (837 aa) |
| | Cdk1 | Protein kinase domain-containing protein. (240 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1117 aa) |
| | Rps27a | Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa) |
| | GTSE1 | G2 and S-phase expressed 1. (718 aa) |
| | CHEK2 | Checkpoint kinase 2. (546 aa) |
| | Babam1 | Uncharacterized protein. (337 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1366 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (834 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (900 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | H0VBD1_CAVPO | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (105 aa) |
| | DBF4 | DBF4 zinc finger. (675 aa) |
| | PKMYT1 | Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (490 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (419 aa) |
| | RFC3 | Replication factor C subunit 3. (220 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (619 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (898 aa) |
| | RMI1 | RecQ mediated genome instability 1. (617 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (716 aa) |
| | TDRD3 | Tudor domain containing 3. (692 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4711 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (350 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (322 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa) |
| | PSMC5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (662 aa) |
| | Clspn | Uncharacterized protein. (1330 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (971 aa) |
| | PSME4 | Proteasome activator subunit 4. (1827 aa) |
| | PSMA8 | Proteasome subunit alpha type. (250 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | CDC7 | Cell division cycle 7. (560 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | LOC106026468 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2744 aa) |
| | Brca1 | Uncharacterized protein. (79 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa) |
| | PSMF1 | Proteasome inhibitor subunit 1. (271 aa) |
| | PSMB5 | Proteasome subunit beta. (263 aa) |
| | PSMA7 | Proteasome endopeptidase complex. (248 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa) |
| | Psmd10 | ANK_REP_REGION domain-containing protein. (232 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (534 aa) |
| | ORC3 | Origin recognition complex subunit 3. (710 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa) |
| | PSMA1 | Proteasome subunit alpha type. (270 aa) |
| | RECQL4 | RecQ like helicase 4. (1226 aa) |
| | RNF169 | Ring finger protein 169. (699 aa) |
| | Wee2 | Wee1-like protein kinase. (557 aa) |
| | Chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa) |
| | PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa) |
| | LOC100720222 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (423 aa) |
| | H0VWS1_CAVPO | ANK_REP_REGION domain-containing protein. (213 aa) |
| | H0VYV4_CAVPO | Uncharacterized protein. (260 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (401 aa) |
| | LOC100728920 | Histone domain-containing protein; Belongs to the histone H2B family. (128 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (398 aa) |
| | Psmd9 | PDZ domain-containing protein. (223 aa) |
| | PSMA4 | Proteasome subunit alpha type. (261 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (731 aa) |
| | LOC111756490 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC100735042 | Histone domain-containing protein; Belongs to the histone H2B family. (125 aa) |
| | PSMB3 | Proteasome subunit beta. (207 aa) |
| | PSMB11 | Proteasome subunit beta. (297 aa) |
| | PSMD5 | Proteasome 26S subunit, non-ATPase 5. (504 aa) |
| | H0W9P9_CAVPO | Wee1-like protein kinase. (551 aa) |
| | H0WAD6_CAVPO | Ubiquitin-like domain-containing protein. (111 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (282 aa) |
| | PSMB10 | Proteasome subunit beta. (273 aa) |
| | H0WDH3_CAVPO | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa) |
| | H0WDT2_CAVPO | Ubiquitin-like domain-containing protein. (127 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | LOC100735546 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | YWHAH | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | Ccnb3 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (1277 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1021 aa) |
| | ENSCPOP00000023065 | ANK_REP_REGION domain-containing protein. (179 aa) |
| | PSME1 | Proteasome activator subunit 1. (249 aa) |
| | ENSCPOP00000023362 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | LOC100717510 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCPOP00000023894 | annotation not available (126 aa) |
| | ORC5 | Origin recognition complex subunit 5. (414 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (291 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa) |
| | LOC100733876 | annotation not available (103 aa) |
| | ENSCPOP00000024311 | annotation not available (126 aa) |
| | ENSCPOP00000024347 | annotation not available (103 aa) |
| | HIST2H2BE | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCPOP00000024383 | annotation not available (126 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | ANKRD12 | Ankyrin repeat domain 12. (2046 aa) |
| | H2BC18 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC100728325 | annotation not available (103 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (233 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | ENSCPOP00000025455 | Protein kinase domain-containing protein. (360 aa) |
| | Tm4sf19 | Uncharacterized protein. (232 aa) |
| | LOC100717396 | Uncharacterized protein. (1249 aa) |
| | LOC100713990 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | CDC25A | Cell division cycle 25A. (519 aa) |
| | ENSCPOP00000026400 | annotation not available (125 aa) |
| | ENSCPOP00000026646 | annotation not available (126 aa) |
| | ENSCPOP00000027005 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (83 aa) |
| | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (358 aa) |
