STRINGSTRING
PSMA3 PSMA3 CDK4 CDK4 LOC100733575 LOC100733575 CCNA1 CCNA1 H0WDT2_CAVPO H0WDT2_CAVPO PSMB10 PSMB10 H0WAD6_CAVPO H0WAD6_CAVPO H0W9P9_CAVPO H0W9P9_CAVPO PSMD5 PSMD5 PSMB3 PSMB3 PSMA4 PSMA4 Psmd9 Psmd9 CUL1 CUL1 H0VWS1_CAVPO H0VWS1_CAVPO PSMC2 PSMC2 Wee2 Wee2 AKT3 AKT3 PSMA1 PSMA1 PSMB4 PSMB4 PSMD3 PSMD3 Psmd10 Psmd10 CDK7 CDK7 MNAT1 MNAT1 PSMA7 PSMA7 PSMB5 PSMB5 PSMF1 PSMF1 PSMA5 PSMA5 Ccne2 Ccne2 Skp2 Skp2 PSMC5 PSMC5 CDKN1B CDKN1B ENSCPOP00000032613 ENSCPOP00000032613 PSME3 PSME3 Psma2 Psma2 Ubc Ubc PSME2 PSME2 ENSCPOP00000031632 ENSCPOP00000031632 AKT2 AKT2 PSMC1 PSMC1 ENSCPOP00000030705 ENSCPOP00000030705 UBA52 UBA52 PSMB8 PSMB8 PSMB1 PSMB1 PSMB6 PSMB6 PSMB9 PSMB9 ENSCPOP00000030079 ENSCPOP00000030079 UBB UBB PSMA6 PSMA6 CKS1B CKS1B PSMB2 PSMB2 ENSCPOP00000029251 ENSCPOP00000029251 PSMD12 PSMD12 CKS2 CKS2 PSMD4 PSMD4 PSMD14 PSMD14 CCND1 CCND1 WEE1 WEE1 PSMD13 PSMD13 PSMC4 PSMC4 CCNE1 CCNE1 SKP1 SKP1 Rps27a Rps27a PSMD6 PSMD6 PTK6 PTK6 CDC25B CDC25B PSMB7 PSMB7 RB1 RB1 PSMC6 PSMC6 PSMD11 PSMD11 CDK2 CDK2 CCNA2 CCNA2 CABLES1 CABLES1 PSMD8 PSMD8 PSMD7 PSMD7 AKT1 AKT1 CDKN1A CDKN1A PSMD2 PSMD2 PSMC3 PSMC3 CCNH CCNH PSME1 PSME1 FZR1 FZR1 ENSCPOP00000023065 ENSCPOP00000023065 PSMD1 PSMD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMA3Proteasome subunit alpha type. (255 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
LOC100733575Uncharacterized protein. (295 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (420 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
PSMB10Proteasome subunit beta. (273 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
H0W9P9_CAVPOWee1-like protein kinase. (551 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
PSMB3Proteasome subunit beta. (207 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
Psmd9PDZ domain-containing protein. (223 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
H0VWS1_CAVPOANK_REP_REGION domain-containing protein. (213 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
Wee2Wee1-like protein kinase. (557 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
PSMA1Proteasome subunit alpha type. (270 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
Psmd10ANK_REP_REGION domain-containing protein. (232 aa)
CDK7Cyclin dependent kinase 7. (335 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
Ccne2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa)
Skp2F-box domain-containing protein. (424 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
ENSCPOP00000032613F-box domain-containing protein. (390 aa)
PSME3Proteasome activator subunit 3. (254 aa)
Psma2Proteasome subunit alpha type. (234 aa)
UbcUncharacterized protein. (159 aa)
PSME2Proteasome activator subunit 2. (239 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
ENSCPOP00000030705CYCLIN domain-containing protein; Belongs to the cyclin family. (341 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
PSMB8Proteasome subunit beta. (273 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMB9Proteasome subunit beta. (219 aa)
ENSCPOP00000030079Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (70 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PSMB2Proteasome subunit beta. (201 aa)
ENSCPOP00000029251Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
WEE1Wee1-like protein kinase. (612 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (315 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (162 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PTK6Tyrosine-protein kinase. (451 aa)
CDC25BCell division cycle 25B. (579 aa)
PSMB7Proteasome subunit beta. (277 aa)
RB1RB transcriptional corepressor 1. (840 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (429 aa)
CABLES1Cdk5 and Abl enzyme substrate 1. (443 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (169 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
PSME1Proteasome activator subunit 1. (249 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
ENSCPOP00000023065ANK_REP_REGION domain-containing protein. (179 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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