STRINGSTRING
IDH2 IDH2 FH FH ACO2 ACO2 IDH3G IDH3G SDHC SDHC LOC100725076 LOC100725076 H0WAF5_CAVPO H0WAF5_CAVPO OGDHL OGDHL IDH3A IDH3A SUCLG1 SUCLG1 Sdhd Sdhd OGDH OGDH ME3 ME3 Dld Dld ENSCPOP00000026353 ENSCPOP00000026353 Sdha Sdha Dlst Dlst MDH2 MDH2 SUCLG2 SUCLG2 CS CS SUCLA2 SUCLA2 IDH3B IDH3B SDHB SDHB ENSCPOP00000032995 ENSCPOP00000032995 NNT NNT ME2 ME2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
FHFumarate hydratase. (508 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (780 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (393 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
LOC100725076Iso_dh domain-containing protein. (377 aa)
H0WAF5_CAVPOIso_dh domain-containing protein. (332 aa)
OGDHLOxoglutarate dehydrogenase like. (1022 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (379 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa)
SdhdSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
ME3Malic enzyme. (604 aa)
DldDihydrolipoyl dehydrogenase. (509 aa)
ENSCPOP00000026353Dihydrolipoyl dehydrogenase. (501 aa)
SdhaSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (652 aa)
DlstLipoyl-binding domain-containing protein. (440 aa)
MDH2Malate dehydrogenase. (338 aa)
SUCLG2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (404 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (457 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (383 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
ENSCPOP00000032995Lipoyl-binding domain-containing protein. (440 aa)
NNTNicotinamide nucleotide transhydrogenase. (1086 aa)
ME2Malic enzyme. (584 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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