STRINGSTRING
Dlst Dlst MDH2 MDH2 L2HGDH L2HGDH PDHX PDHX PPARD PPARD LDHC LDHC SUCLG2 SUCLG2 CS CS SUCLA2 SUCLA2 IDH3B IDH3B MPC1L MPC1L SLC16A3 SLC16A3 H0VXJ2_CAVPO H0VXJ2_CAVPO PDPR PDPR PNKD PNKD SDHB SDHB PDK2 PDK2 SLC16A1 SLC16A1 BSG BSG H0W5C1_CAVPO H0W5C1_CAVPO SLC16A8 SLC16A8 PDP2 PDP2 OGDHL OGDHL H0WAF5_CAVPO H0WAF5_CAVPO LOC100725076 LOC100725076 PDK1 PDK1 HAGHL HAGHL MPC1 MPC1 SDHC SDHC IDH3G IDH3G ACO2 ACO2 FH FH ENSCPOP00000023749 ENSCPOP00000023749 LDHA LDHA Adhfe1 Adhfe1 ENSCPOP00000026353 ENSCPOP00000026353 MBLAC2 MBLAC2 HAGH HAGH Ldhb Ldhb Vdac1 Vdac1 ENSCPOP00000029147 ENSCPOP00000029147 MPC2 MPC2 ME2 ME2 NNT NNT GLO1 GLO1 DLAT DLAT ENSCPOP00000032995 ENSCPOP00000032995 PDK4 PDK4 D2HGDH D2HGDH RXRA RXRA IDH3A IDH3A GSTZ1 GSTZ1 ME1 ME1 SUCLG1 SUCLG1 Sdhd Sdhd OGDH OGDH ME3 ME3 Dld Dld PDHB PDHB LACTB2 LACTB2 PDK3 PDK3 IDH2 IDH2 Sdha Sdha Pdha1 Pdha1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DlstLipoyl-binding domain-containing protein. (440 aa)
MDH2Malate dehydrogenase. (338 aa)
L2HGDHL-2-hydroxyglutarate dehydrogenase. (463 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (442 aa)
PPARDPeroxisome proliferator activated receptor delta. (440 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
SUCLG2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (404 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (457 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (383 aa)
MPC1LMitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (123 aa)
SLC16A3Solute carrier family 16 member 3. (465 aa)
H0VXJ2_CAVPOUncharacterized protein. (240 aa)
PDPRPyruvate dehydrogenase phosphatase regulatory subunit. (838 aa)
PNKDPNKD metallo-beta-lactamase domain containing. (424 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
SLC16A1Solute carrier family 16 member 1. (501 aa)
BSGBasigin (Ok blood group). (384 aa)
H0W5C1_CAVPOPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
SLC16A8Solute carrier family 16 member 8. (405 aa)
PDP2Pyruvate dehyrogenase phosphatase catalytic subunit 2. (530 aa)
OGDHLOxoglutarate dehydrogenase like. (1022 aa)
H0WAF5_CAVPOIso_dh domain-containing protein. (332 aa)
LOC100725076Iso_dh domain-containing protein. (377 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
HAGHLHydroxyacylglutathione hydrolase like. (228 aa)
MPC1Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (109 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (393 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (780 aa)
FHFumarate hydratase. (508 aa)
ENSCPOP00000023749Uncharacterized protein. (244 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
Adhfe1Fe-ADH domain-containing protein. (466 aa)
ENSCPOP00000026353Dihydrolipoyl dehydrogenase. (501 aa)
MBLAC2Metallo-beta-lactamase domain containing 2. (279 aa)
HAGHHydroxyacylglutathione hydrolase. (260 aa)
LdhbL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
Vdac1Uncharacterized protein. (283 aa)
ENSCPOP00000029147Uncharacterized protein. (272 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
ME2Malic enzyme. (584 aa)
NNTNicotinamide nucleotide transhydrogenase. (1086 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (185 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (650 aa)
ENSCPOP00000032995Lipoyl-binding domain-containing protein. (440 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
D2HGDHD-2-hydroxyglutarate dehydrogenase. (538 aa)
RXRARetinoid X receptor alpha. (459 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (379 aa)
GSTZ1Glutathione S-transferase zeta 1. (174 aa)
ME1Malic enzyme. (501 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa)
SdhdSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
ME3Malic enzyme. (604 aa)
DldDihydrolipoyl dehydrogenase. (509 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
LACTB2Lactamase beta 2. (288 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
SdhaSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (652 aa)
Pdha1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.