53 items (Cavia porcellus) - STRING interaction network

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	TDG	Thymine DNA glycosylase. (413 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	SMUG1	Single-strand-selective monofunctional uracil-DNA glycosylase 1. (272 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	XRCC1	X-ray repair cross complementing 1. (629 aa)
	ADPRHL2	ADP-ribosylhydrolase like 2. (367 aa)
	MPG	N-methylpurine DNA glycosylase. (300 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (551 aa)
	RPA3	Replication protein A3. (121 aa)
	LOC100713990	Histone H2B; Belongs to the histone H2B family. (126 aa)
	UNG-2	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (311 aa)
	ENSCPOP00000024428	PARP-type domain-containing protein. (104 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	Pold4	Uncharacterized protein. (107 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (116 aa)
	POLD1	DNA polymerase. (1134 aa)
	UNG	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (298 aa)
	VWA5B2	Von Willebrand factor A domain containing 5B2. (1204 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (469 aa)
	PARP2	Poly [ADP-ribose] polymerase. (536 aa)
	RFC5	Replication factor C subunit 5. (340 aa)
	Parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
	H0VSI3_CAVPO	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
	PARG	Poly(ADP-ribose) glycohydrolase. (973 aa)
	PARP3	Poly [ADP-ribose] polymerase. (533 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
	Rec114	Uncharacterized protein. (82 aa)
	LIG3	DNA ligase. (1012 aa)
	Mutyh	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (530 aa)
	RFC2	Replication factor C subunit 2. (352 aa)
	ATAD5	ATPase family AAA domain containing 5. (1831 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	NEIL1	Nei like DNA glycosylase 1. (401 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (340 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	OGG1	8-oxoguanine DNA glycosylase. (303 aa)
	RPA2	Replication protein A2. (270 aa)
	RFC3	Replication factor C subunit 3. (220 aa)
	APEX2	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (514 aa)
	Pold3	Uncharacterized protein. (466 aa)
	NEIL2	Nei like DNA glycosylase 2. (336 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (523 aa)
	H0V4D6_CAVPO	Uncharacterized protein. (176 aa)
	VWA5A	Von Willebrand factor A domain containing 5A. (798 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	RFC1	Replication factor C subunit 1. (1153 aa)
	Lig1	DNA ligase. (909 aa)
	NEIL3	Nei like DNA glycosylase 3. (607 aa)
	NTHL1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (260 aa)
	VWA5B1	Von Willebrand factor A domain containing 5B1. (1203 aa)
	MEIOB	Meiosis specific with OB-fold. (471 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADPRHL2	PARG	ENSCPOP00000031096	ENSCPOP00000012887	ADP-ribosylhydrolase like 2.	Poly(ADP-ribose) glycohydrolase.	0.553
ADPRHL2	PARP3	ENSCPOP00000031096	ENSCPOP00000012500	ADP-ribosylhydrolase like 2.	Poly [ADP-ribose] polymerase.	0.592
APEX1	APEX2	ENSCPOP00000032125	ENSCPOP00000006545	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.927
APEX1	ATAD5	ENSCPOP00000032125	ENSCPOP00000010706	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	ATPase family AAA domain containing 5.	0.696
APEX1	ENSCPOP00000024428	ENSCPOP00000032125	ENSCPOP00000024428	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	PARP-type domain-containing protein.	0.755
APEX1	FEN1	ENSCPOP00000032125	ENSCPOP00000032223	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.994
APEX1	H0V4D6_CAVPO	ENSCPOP00000032125	ENSCPOP00000004474	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Uncharacterized protein.	0.646
APEX1	H0VSI3_CAVPO	ENSCPOP00000032125	ENSCPOP00000013590	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family.	0.846
APEX1	LIG3	ENSCPOP00000032125	ENSCPOP00000011732	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA ligase.	0.840
APEX1	Lig1	ENSCPOP00000032125	ENSCPOP00000003796	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA ligase.	0.846
APEX1	MEIOB	ENSCPOP00000032125	ENSCPOP00000001396	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Meiosis specific with OB-fold.	0.590
APEX1	MPG	ENSCPOP00000032125	ENSCPOP00000028846	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	N-methylpurine DNA glycosylase.	0.780
APEX1	Mutyh	ENSCPOP00000032125	ENSCPOP00000011204	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.909
APEX1	NEIL1	ENSCPOP00000032125	ENSCPOP00000009702	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Nei like DNA glycosylase 1.	0.410
APEX1	NEIL3	ENSCPOP00000032125	ENSCPOP00000002978	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Nei like DNA glycosylase 3.	0.525
APEX1	NTHL1	ENSCPOP00000032125	ENSCPOP00000002908	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.996
APEX1	OGG1	ENSCPOP00000032125	ENSCPOP00000007880	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	8-oxoguanine DNA glycosylase.	0.902
APEX1	PARG	ENSCPOP00000032125	ENSCPOP00000012887	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Poly(ADP-ribose) glycohydrolase.	0.626
APEX1	PARP2	ENSCPOP00000032125	ENSCPOP00000018168	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Poly [ADP-ribose] polymerase.	0.789
APEX1	PARP3	ENSCPOP00000032125	ENSCPOP00000012500	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Poly [ADP-ribose] polymerase.	0.508